A star in a 15.2-year orbit around the supermassive black hole at the centre of the Milky Way.

abstract：:Three-wave mixing in nonlinear materials--the interaction of two light waves to produce a third--is a convenient way of generating new optical frequencies from common laser sources. However, the resulting optical conversion yield is generally poor, because the relative phases of the three interacting waves change cont...

journal_title：Nature

authors： Baudrier-Raybaut M,Haïdar R,Kupecek P,Lemasson P,Rosencher E

更新日期：2004-11-18 00:00:00

abstract：:DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...

journal_title：Nature

authors： Calo E,Flynn RA,Martin L,Spitale RC,Chang HY,Wysocka J

更新日期：2015-02-12 00:00:00

abstract：:The polypeptide chains that make up proteins have thousands of atoms and hence millions of possible inter-atomic interactions. It might be supposed that the resulting complexity would make prediction of protein structure and protein-folding mechanisms nearly impossible. But the fundamental physics underlying folding m...

journal_title：Nature

authors： Baker D

更新日期：2000-05-04 00:00:00

abstract：:The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins differe...

journal_title：Nature

authors： Maniatis T,Tasic B

更新日期：2002-07-11 00:00:00

abstract：:A long-standing hypothesis posits that natural selection can favour two female strategies when density cycles. At low density, females producing many smaller progeny are favoured when the intrinsic rate of increase, r, governs population growth. At peak density, females producing fewer, high-quality, progeny are favou...

journal_title：Nature

authors： Sinervo B,Svensson E,Comendant T

更新日期：2000-08-31 00:00:00

abstract：:At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constitu...

journal_title：Nature

authors： Kuma A,Hatano M,Matsui M,Yamamoto A,Nakaya H,Yoshimori T,Ohsumi Y,Tokuhisa T,Mizushima N

更新日期：2004-12-23 00:00:00

abstract：:White dwarfs represent the endpoint of stellar evolution for stars with initial masses between approximately 0.07 and 8-10, where is the mass of the Sun (more massive stars end their life as either black holes or neutron stars). The theory of stellar evolution predicts that the majority of white dwarfs have a core mad...

journal_title：Nature

authors： Dufour P,Liebert J,Fontaine G,Behara N

更新日期：2007-11-22 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:According to the generally accepted scenario, the last giant impact on Earth formed the Moon and initiated the final phase of core formation by melting Earth's mantle. A key goal of geochemistry is to date this event, but different ages have been proposed. Some argue for an early Moon-forming event, approximately 30 m...

journal_title：Nature

authors： Jacobson SA,Morbidelli A,Raymond SN,O'Brien DP,Walsh KJ,Rubie DC

更新日期：2014-04-03 00:00:00

abstract：:Rab GTPases regulate all stages of membrane trafficking, including vesicle budding, cargo sorting, transport, tethering and fusion. In the inactive (GDP-bound) conformation, accessory factors facilitate the targeting of Rab GTPases to intracellular compartments. After nucleotide exchange to the active (GTP-bound) conf...

journal_title：Nature

authors： Eathiraj S,Pan X,Ritacco C,Lambright DG

更新日期：2005-07-21 00:00:00

abstract：:The classical view of fast chemical synaptic transmission is that released neurotransmitter acts locally on postsynaptic receptors and is cleared from the synaptic cleft within a few milliseconds by diffusion and by specific reuptake mechanisms. This rapid clearance restricts the spread of neurotransmitter and, combin...

journal_title：Nature

authors： Scanziani M,Salin PA,Vogt KE,Malenka RC,Nicoll RA

更新日期：1997-02-13 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

journal_title：Nature

authors： Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

更新日期：1997-09-04 00:00:00

abstract：:The determination of molecular masses from barometric sedimentation profiles, a main topic in ultracentrifugal analysis, is thought to be quantitatively correct for non-interacting particles. Whereas this expectation is justified for uncharged colloids or macromolecules at low volume fractions, early ultracentrifugati...

journal_title：Nature

authors： Raşa M,Philipse AP

更新日期：2004-06-24 00:00:00

abstract：:So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma kindreds. Here we report the who...

journal_title：Nature

authors： Yokoyama S,Woods SL,Boyle GM,Aoude LG,MacGregor S,Zismann V,Gartside M,Cust AE,Haq R,Harland M,Taylor JC,Duffy DL,Holohan K,Dutton-Regester K,Palmer JM,Bonazzi V,Stark MS,Symmons J,Law MH,Schmidt C,Lanagan C,O'C

更新日期：2011-11-13 00:00:00

abstract：:In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...

journal_title：Nature

authors： Gao J,Barzel B,Barabási AL

更新日期：2019-04-01 00:00:00

abstract：:Most Oryza sativa cultivars die within a week of complete submergence--a major constraint to rice production in south and southeast Asia that causes annual losses of over US 1 billion dollars and affects disproportionately the poorest farmers in the world. A few cultivars, such as the O. sativa ssp. indica cultivar FR...

journal_title：Nature

authors： Xu K,Xu X,Fukao T,Canlas P,Maghirang-Rodriguez R,Heuer S,Ismail AM,Bailey-Serres J,Ronald PC,Mackill DJ

更新日期：2006-08-10 00:00:00

abstract：:The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...

journal_title：Nature

authors： Ciais P,Tan J,Wang X,Roedenbeck C,Chevallier F,Piao SL,Moriarty R,Broquet G,Le Quéré C,Canadell JG,Peng S,Poulter B,Liu Z,Tans P

更新日期：2019-04-01 00:00:00

abstract：:An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell line...

journal_title：Nature

authors： Kirkwood TB

更新日期：1977-11-24 00:00:00

abstract：:The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after conception until birth, including transcriptomes, methylomes and chromatin states. Here we systematically examined th...

journal_title：Nature

authors： Gorkin DU,Barozzi I,Zhao Y,Zhang Y,Huang H,Lee AY,Li B,Chiou J,Wildberg A,Ding B,Zhang B,Wang M,Strattan JS,Davidson JM,Qiu Y,Afzal V,Akiyama JA,Plajzer-Frick I,Novak CS,Kato M,Garvin TH,Pham QT,Harrington AN

更新日期：2020-07-01 00:00:00

abstract：:Aerobic methanotrophic bacteria consume methane as it diffuses away from methanogenic zones of soil and sediment. They act as a biofilter to reduce methane emissions to the atmosphere, and they are therefore targets in strategies to combat global climate change. No cultured methanotroph grows optimally below pH 5, but...

journal_title：Nature

authors： Dunfield PF,Yuryev A,Senin P,Smirnova AV,Stott MB,Hou S,Ly B,Saw JH,Zhou Z,Ren Y,Wang J,Mountain BW,Crowe MA,Weatherby TM,Bodelier PL,Liesack W,Feng L,Wang L,Alam M

更新日期：2007-12-06 00:00:00

abstract：:The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average d...

journal_title：Nature

authors： Lasonder E,Ishihama Y,Andersen JS,Vermunt AM,Pain A,Sauerwein RW,Eling WM,Hall N,Waters AP,Stunnenberg HG,Mann M

更新日期：2002-10-03 00:00:00

abstract：:In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

journal_title：Nature

authors： Belote JM,Lucchesi JC

更新日期：1980-06-19 00:00:00

abstract：:The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby on...

journal_title：Nature

authors： Hood L,Galas D

更新日期：2003-01-23 00:00:00

abstract：:The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...

journal_title：Nature

authors： Stuber GD,Sparta DR,Stamatakis AM,van Leeuwen WA,Hardjoprajitno JE,Cho S,Tye KM,Kempadoo KA,Zhang F,Deisseroth K,Bonci A

更新日期：2011-06-29 00:00:00

abstract：:How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the developing heart, the myocardium transitions from a simple epithelium to an intricate tissue that consists of distinct layers: the outer compact and inner trabecular layers. Defects in this p...

journal_title：Nature

authors： Priya R,Allanki S,Gentile A,Mansingh S,Uribe V,Maischein HM,Stainier DYR

更新日期：2020-12-01 00:00:00

abstract：:Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...

journal_title：Nature

authors： Ebers GC,Sadovnick AD,Risch NJ

更新日期：1995-09-14 00:00:00

abstract：:Some surprising facts about the most productive institutions emerge when Japanese life-science research is subject to a novel type of assessment. ...

journal_title：Nature

authors： Yamazaki S

更新日期：1994-11-10 00:00:00

abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

journal_title：Nature

authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

更新日期：2015-02-26 00:00:00

abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

journal_title：Nature

authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

更新日期：2012-11-29 00:00:00

abstract：:Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocy...

journal_title：Nature

authors： Wendling F,Maraskovsky E,Debili N,Florindo C,Teepe M,Titeux M,Methia N,Breton-Gorius J,Cosman D,Vainchenker W

更新日期：1994-06-16 00:00:00