Alternative pre-mRNA splicing and proteome expansion in metazoans.

abstract：:Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...

journal_title：Nature

authors： Snowden RJ,Hammett ST

更新日期：1992-01-16 00:00:00

abstract：:Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...

journal_title：Nature

authors： van der Pluijm BA,Hall CM,Vrolijk PJ,Pevear DR,Covey MC

更新日期：2001-07-12 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Acetylcholine (ACh) released on vagal stimulation reduces the heart rate by increasing K+ conductance of pacemaker cells in the sinoatrial (S-A) node. Fluctuation analysis of ACh-activated currents in pacemaker tissue showed this to be due to opening of a separate class of K+ channels gated by muscarinic ACh receptors...

journal_title：Nature

authors： Sakmann B,Noma A,Trautwein W

更新日期：1983-05-19 00:00:00

abstract：:Hypogonadism in the mutant hpg mouse is characterized by a deficiency of hypothalamic gonadotropin releasing hormone (GnRH). Affected male mice exhibit immature reproductive organs, small abdominal testes and low pituitary and plasma gonadotropin concentrations. Recent studies have demonstrated the potential of fetal ...

journal_title：Nature

authors： Krieger DT,Perlow MJ,Gibson MJ,Davies TF,Zimmerman EA,Ferin M,Charlton HM

更新日期：1982-07-29 00:00:00

abstract：:Mycorrhizae, the symbiotic associations of plant roots and fungal hyphae, are classic examples of mutualisms. In these ecologically important associations, the fungi derive photosynthetic sugars from their plant hosts, which in turn benefit from fungus-mediated uptake of mineral nutrients. Early views on the evolution...

journal_title：Nature

authors： Hibbett DS,Gilbert LB,Donoghue MJ

更新日期：2000-09-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Silver A

更新日期：2019-01-01 00:00:00

abstract：:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines te...

journal_title：Nature

authors： Omary MB,Trowbridge IS,Minowada J

更新日期：1980-08-28 00:00:00

abstract：:The three-dimensional structure of the 67K amino-terminal fragment of Escherichia coli DNA topoisomerase I has been determined to 2.2 A resolution. The polypeptide folds in an unusual way to give four distinct domains enclosing a hole large enough to accommodate a double-stranded DNA. The active-site tyrosyl residue, ...

journal_title：Nature

authors： Lima CD,Wang JC,Mondragón A

更新日期：1994-01-13 00:00:00

abstract：:Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGRF seems to be important for its biological effects, as reduction irreve...

journal_title：Nature

authors： Heldin CH,Johnsson A,Wennergren S,Wernstedt C,Betsholtz C,Westermark B

更新日期：1986-02-06 00:00:00

abstract：:Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. ...

journal_title：Nature

authors： Stockwell BR

更新日期：2004-12-16 00:00:00

abstract：:The analysis of mutations affecting flower structure has led to the identification of some of the genes that direct flower development. Cloning of these genes has allowed the formulation of molecular models of how floral meristem and organ identity may be specified, and has shown that the distantly related flowering p...

journal_title：Nature

authors： Coen ES,Meyerowitz EM

更新日期：1991-09-05 00:00:00

abstract：:Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...

journal_title：Nature

authors： Lee J,Fujita K,McElroy K,Slezak JA,Wang M,Aiura Y,Bando H,Ishikado M,Masui T,Zhu JX,Balatsky AV,Eisaki H,Uchida S,Davis JC

更新日期：2006-08-03 00:00:00

abstract：:Ionic currents from individual K+ channels in squid axon membrane have been recorded. At hyperpolarizing membrane voltages, unit events occur as widely spaced rectangular pulses with short interruptions. The frequency of occurrence of the units increases strongly when the membrane is depolarized. ...

journal_title：Nature

authors： Conti F,Neher E

更新日期：1980-05-15 00:00:00

abstract：:The taxonomy of a parasite can be an important guide to its pathogenic characteristics. A wide range of anatomical, biochemical and behavioural tests is now being developed to define different strains and subspecies of the main tropical parasites. ...

journal_title：Nature

authors： Godfrey DG

更新日期：1978-06-22 00:00:00

abstract：:Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...

journal_title：Nature

authors： Gilmore CK,McCarthy SE,Spelke ES

更新日期：2007-05-31 00:00:00

abstract：:Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation clock', which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain l...

journal_title：Nature

authors： Horikawa K,Ishimatsu K,Yoshimoto E,Kondo S,Takeda H

更新日期：2006-06-08 00:00:00

abstract：:CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...

journal_title：Nature

authors： Paliard X,Malefijt RW,de Vries JE,Spits H

更新日期：1988-10-13 00:00:00

abstract：:Real-time investigations of the rearrangement of bonds during chemical transformations require femtosecond temporal resolution, so that the atomic vibrations within the reacting molecules can be observed. Following the development of lasers capable of emitting ultrashort laser flashes on this timescale, chemical react...

journal_title：Nature

authors： Kobayashi T,Saito T,Ohtani H

更新日期：2001-11-29 00:00:00

abstract：:Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...

journal_title：Nature

authors： Fonseca-Pereira D,Arroz-Madeira S,Rodrigues-Campos M,Barbosa IA,Domingues RG,Bento T,Almeida AR,Ribeiro H,Potocnik AJ,Enomoto H,Veiga-Fernandes H

更新日期：2014-10-02 00:00:00

abstract：:The human alpha-interferon (IFN-alpha) gene family consists of at least 14 potentially functional non-allelic members; the amino acid sequences they encode differ from each other by up to approximately 20% of their residues. Human IFN-beta, which is encoded by a single gene, is distantly related to the IFN-alpha famil...

journal_title：Nature

authors： Valenzuela D,Weber H,Weissmann C

更新日期：1985-02-21 00:00:00

abstract：:Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local d...

journal_title：Nature

authors： Gambino F,Pagès S,Kehayas V,Baptista D,Tatti R,Carleton A,Holtmaat A

更新日期：2014-11-06 00:00:00

abstract：:Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult p...

journal_title：Nature

authors： Yamada M,Miyakawa T,Duttaroy A,Yamanaka A,Moriguchi T,Makita R,Ogawa M,Chou CJ,Xia B,Crawley JN,Felder CC,Deng CX,Wess J

更新日期：2001-03-08 00:00:00

abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...

journal_title：Nature

authors： Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

更新日期：1990-10-25 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Retrospective epidemiological data have indicated that cutaneous malignant melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet radiation, particularly in children, rather than from the cumulative lifetime exposure that is associated with other forms of skin cancer. Here we ...

journal_title：Nature

authors： Noonan FP,Recio JA,Takayama H,Duray P,Anver MR,Rush WL,De Fabo EC,Merlino G

更新日期：2001-09-20 00:00:00

abstract：:Supramolecular soft crystals are periodic structures that are formed by the hierarchical assembly of complex constituents, and occur in a broad variety of 'soft-matter' systems1. Such soft crystals exhibit many of the basic features (such as three-dimensional lattices and space groups) and properties (such as band str...

journal_title：Nature

authors： Feng X,Burke CJ,Zhuo M,Guo H,Yang K,Reddy A,Prasad I,Ho RM,Avgeropoulos A,Grason GM,Thomas EL

更新日期：2019-11-01 00:00:00

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are ancient asexually reproducing organisms that form symbioses with the majority of plant species, improving plant nutrition and promoting plant diversity. Little is known about the evolution or organization of the genomes of any eukaryotic symbiont or ancient asexual organism. Dire...

journal_title：Nature

authors： Hijri M,Sanders IR

更新日期：2005-01-13 00:00:00

abstract：:Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...

journal_title：Nature

authors： Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

更新日期：2020-09-01 00:00:00