Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I.

abstract：:For the past couple of centuries the penchant for prediction has been prevalent at century turns. How much have evaluations of scientific discovery and predictions for future advancement changed since those of the science commentators at the end of the last century? ...

journal_title：Nature

authors： Heilbron JL,Bynum WF

更新日期：1999-12-02 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...

journal_title：Nature

authors： Sterzik MF,Bagnulo S,Palle E

更新日期：2012-02-29 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...

journal_title：Nature

authors： Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

更新日期：2005-02-03 00:00:00

abstract：:Type III collagen is often found in the same tissues as type I collagen, yet the function and nature of the fibrils formed by the two collagens differ markedly. To understand the evolutionary history of the collagen gene family in more detail, we isolated the gene for type III collagen and compared its structure with ...

journal_title：Nature

authors： Yamada Y,Liau G,Mudryj M,Obici S,de Crombrugghe B

更新日期：1984-07-26 00:00:00

abstract：:The theory of electric polarization in crystals defines the dipole moment of an insulator in terms of a Berry phase (geometric phase) associated with its electronic ground state. This concept not only solves the long-standing puzzle of how to calculate dipole moments in crystals, but also explains topological band str...

journal_title：Nature

authors： Peterson CW,Benalcazar WA,Hughes TL,Bahl G

更新日期：2018-03-14 00:00:00

abstract：:The erosion of mountain belts controls their topographic and structural evolution and is the main source of sediment delivered to the oceans. Mountain erosion rates have been estimated from current relief and precipitation, but a more complete evaluation of the controls on erosion rates requires detailed measurements ...

journal_title：Nature

authors： Dadson SJ,Hovius N,Chen H,Dade WB,Hsieh ML,Willett SD,Hu JC,Horng MJ,Chen MC,Stark CP,Lague D,Lin JC

更新日期：2003-12-11 00:00:00

abstract：:Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I foot...

journal_title：Nature

authors： Vierstra J,Lazar J,Sandstrom R,Halow J,Lee K,Bates D,Diegel M,Dunn D,Neri F,Haugen E,Rynes E,Reynolds A,Nelson J,Johnson A,Frerker M,Buckley M,Kaul R,Meuleman W,Stamatoyannopoulos JA

更新日期：2020-07-01 00:00:00

abstract：:Humans are colour-blind at night, and it has been assumed that this is true of all animals. But colour vision is as useful for discriminating objects at night as it is during the day. Here we show, through behavioural experiments, that the nocturnal hawkmoth Deilephila elpenor uses colour vision to discriminate colour...

journal_title：Nature

authors： Kelber A,Balkenius A,Warrant EJ

更新日期：2002-10-31 00:00:00

abstract：:The ability to confine and store optical energy in small volumes has implications in fields ranging from cavity quantum electrodynamics to photonics. Of all cavity geometries, micrometre-sized dielectric spherical resonators are the best in terms of their ability to store energy for long periods of time within small v...

journal_title：Nature

authors： Spillane SM,Kippenberg TJ,Vahala KJ

更新日期：2002-02-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Luteijn RD,Zaver SA,Gowen BG,Wyman SK,Garelis NE,Onia L,McWhirter SM,Katibah GE,Corn JE,Woodward JJ,Raulet DH

更新日期：2020-03-01 00:00:00

abstract：:Ultrathin ferroelectric materials could potentially enable low-power perovskite ferroelectric tetragonality logic and nonvolatile memories1,2. As ferroelectric materials are made thinner, however, the ferroelectricity is usually suppressed. Size effects in ferroelectrics have been thoroughly investigated in perovskite...

journal_title：Nature

authors： Cheema SS,Kwon D,Shanker N,Dos Reis R,Hsu SL,Xiao J,Zhang H,Wagner R,Datar A,McCarter MR,Serrao CR,Yadav AK,Karbasian G,Hsu CH,Tan AJ,Wang LC,Thakare V,Zhang X,Mehta A,Karapetrova E,Chopdekar RV,Shafer P,Arenh

更新日期：2020-04-01 00:00:00

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：:Generalization is a cognitive ability that allows similar stimuli along a given dimension to be treated as equivalents. Insects exhibit high levels of visual generalization. Honeybees trained to recognize complex visual stimuli on the basis of a single feature generalize their choice to novel stimuli sharing that comm...

journal_title：Nature

authors： Stach S,Benard J,Giurfa M

更新日期：2004-06-17 00:00:00

abstract：:There is ample evidence that the secretion of follicle stimulating hormone (FSH) by the pituitary gland is regulated by a nonsteroidal hormone of gonadal origin, termed inhibin. In several species, testicular extracts, gonadal lymph and seminal plasma have been shown to contain proteins which inhibit FSH release; lack...

journal_title：Nature

authors： Scott RS,Burger HG

更新日期：1980-05-22 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...

journal_title：Nature

authors： Parfitt SA,Ashton NM,Lewis SG,Abel RL,Coope GR,Field MH,Gale R,Hoare PG,Larkin NR,Lewis MD,Karloukovski V,Maher BA,Peglar SM,Preece RC,Whittaker JE,Stringer CB

更新日期：2010-07-08 00:00:00

abstract：:The effect of anthropogenic aerosols on cloud droplet concentrations and radiative properties is the source of one of the largest uncertainties in the radiative forcing of climate over the industrial period. This uncertainty affects our ability to estimate how sensitive the climate is to greenhouse gas emissions. Here...

journal_title：Nature

authors： Carslaw KS,Lee LA,Reddington CL,Pringle KJ,Rap A,Forster PM,Mann GW,Spracklen DV,Woodhouse MT,Regayre LA,Pierce JR

更新日期：2013-11-07 00:00:00

abstract：:The cyc- variants of S49 lymphoma cells have served as powerful tools for studying the components and mechanisms of hormone-induced adenylate cyclase stimulation, as these cells are deficient in the guanine nucleotide regulatory site (Ns) mediating hormone, guanine nucleotide, cholera toxin and fluoride-induced stimul...

journal_title：Nature

authors： Jakobs KH,Aktories K,Schultz G

更新日期：1983-05-12 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00

abstract：:Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...

journal_title：Nature

authors： Akyuz N,Altman RB,Blanchard SC,Boudker O

更新日期：2013-10-03 00:00:00

abstract：:The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average d...

journal_title：Nature

authors： Lasonder E,Ishihama Y,Andersen JS,Vermunt AM,Pain A,Sauerwein RW,Eling WM,Hall N,Waters AP,Stunnenberg HG,Mann M

更新日期：2002-10-03 00:00:00

abstract：:Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown. Here we show, by lineage tracking in zebrafish embryos, that angioblast precursors for the trunk artery and vein are spatially mixed in the lateral posterior me...

journal_title：Nature

authors： Zhong TP,Childs S,Leu JP,Fishman MC

更新日期：2001-11-08 00:00:00

abstract：:Supramolecular soft crystals are periodic structures that are formed by the hierarchical assembly of complex constituents, and occur in a broad variety of 'soft-matter' systems1. Such soft crystals exhibit many of the basic features (such as three-dimensional lattices and space groups) and properties (such as band str...

journal_title：Nature

authors： Feng X,Burke CJ,Zhuo M,Guo H,Yang K,Reddy A,Prasad I,Ho RM,Avgeropoulos A,Grason GM,Thomas EL

更新日期：2019-11-01 00:00:00

abstract：:Understanding the capacity of natural populations to adapt to their local environment is a central topic in evolutionary biology. Phenotypic differences between populations may have a genetic basis, but showing that they reflect different adaptive optima requires the quantification of both gene flow and selection. Goo...

journal_title：Nature

authors： Postma E,van Noordwijk AJ

更新日期：2005-01-06 00:00:00

abstract：:Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...

journal_title：Nature

authors： Ishida S,Iwamoto T,Kabuto C,Kira M

更新日期：2003-02-13 00:00:00

abstract：:Good health, which reflects the harmonious integration of molecules, cells, tissues and organs, is dynamically stable: when displaced by disease, compensation and correction are common, even without medical care. Physiology and computational biology now suggest that healthy dynamic stability arises through the combina...

journal_title：Nature

authors： Buchman TG

更新日期：2002-11-14 00:00:00

abstract：:ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...

journal_title：Nature

authors： Pebay-Peyroula E,Dahout-Gonzalez C,Kahn R,Trézéguet V,Lauquin GJ,Brandolin G

更新日期：2003-11-06 00:00:00

abstract：:Regulation of cell proliferation is necessary for immune responses, tissue repair, and upkeep of organ function to maintain human health. When proliferating cells complete mitosis, a fraction of newly born daughter cells immediately enter the next cell cycle, while the remaining cells in the same population exit to a ...

journal_title：Nature

authors： Yang HW,Chung M,Kudo T,Meyer T

更新日期：2017-09-21 00:00:00