Abstract:
:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage complex dependent on the presence of ATP.
journal_name
Naturejournal_title
Natureauthors
Yuan R,Bickle TA,Ebbers W,Brack Cdoi
10.1038/256556a0keywords:
subject
Has Abstractpub_date
1975-08-14 00:00:00pages
556-60issue
5518eissn
0028-0836issn
1476-4687journal_volume
256pub_type
杂志文章相关文献
NATURE文献大全abstract::A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11209
更新日期:2012-06-13 00:00:00
abstract::Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09581
更新日期:2010-12-23 00:00:00
abstract::During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21046
更新日期:2017-02-16 00:00:00
abstract::Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318377a0
更新日期:1985-11-28 00:00:00
abstract::Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/440436a
更新日期:2006-03-23 00:00:00
abstract::More than 30 years ago, human beings looked back from the Moon to see the magnificent spectacle of Earth-rise. The technology that put us into space has since been used to assess the damage we are doing to our natural environment and is now being harnessed to monitor and predict diseases through space and time. Satell...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/415710a
更新日期:2002-02-07 00:00:00
abstract::The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20173
更新日期:2017-01-12 00:00:00
abstract::Distinctive acute brain damage involving limbic and related brain regions develops in adult rats following sustained limbic seizures induced by systemic administration of kainic acid or dipiperidinoethane (DPE) or by intra-amygdaloid injection of kainic acid or folic acid. This seizure-brain damage (S-BD) syndrome is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301520a0
更新日期:1983-02-10 00:00:00
abstract::Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04490
更新日期:2006-02-16 00:00:00
abstract::Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00997
更新日期:2002-09-05 00:00:00
abstract::The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic sel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/292502a0
更新日期:1981-08-06 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0796-5
更新日期:2018-12-01 00:00:00
abstract::Temperature and fluid pressure conditions control rock deformation and mineralization on geological faults, and hence the distribution of earthquakes. Typical intraplate continental crust has hydrostatic fluid pressure and a near-surface thermal gradient of 31 ± 15 degrees Celsius per kilometre. At temperatures above ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22355
更新日期:2017-06-01 00:00:00
abstract::Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/414751a
更新日期:2001-12-13 00:00:00
abstract::Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07037
更新日期:2008-05-15 00:00:00
abstract::Relapse to cocaine use after prolonged abstinence is an important clinical problem. This relapse is often induced by exposure to cues associated with cocaine use. To account for the persistent propensity for relapse, it has been suggested that cue-induced cocaine craving increases over the first several weeks of absti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06995
更新日期:2008-07-03 00:00:00
abstract::The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in rodents. Given the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07427
更新日期:2008-12-11 00:00:00
abstract::Interleukin-2 (IL-2) has a key role in the antigen-specific clonal growth of T lymphocytes, by virtue of its interaction with a specific cell-surface receptor (IL-2R). The growth signal seems to be delivered by IL-2 bound to the high-affinity, but not the low-affinity, receptor. Genes encoding IL-2 and its receptor (t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318467a0
更新日期:1985-12-05 00:00:00
abstract::Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record aga...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature14258
更新日期:2015-03-12 00:00:00
abstract::The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10194
更新日期:2011-06-29 00:00:00
abstract::It is generally thought that interspecific (lateral) transfer of genes is so extensive among bacteria that it is difficult, and perhaps impossible, to determine their phylogenetic relationships. Ambler and coworkers reflect this in their suggestion that the relationships seen among cytochrome c sequences of the Rhodos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283212a0
更新日期:1980-01-10 00:00:00
abstract::TATA-binding protein (TBP) binds the minor groove of the TATA element with the DNA bent 80 degrees towards the major groove. A constrained minicircle strategy has been used to test the effect of DNA topology on the affinity of TBP for the TATA element. We report here that TBP bound to DNA which was slightly pre-bent t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373724a0
更新日期:1995-02-23 00:00:00
abstract::Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07776
更新日期:2009-03-19 00:00:00
abstract::A major problem in the elucidation of the molecular mechanisms governing development is the distinction between direct and indirect regulatory interactions among developmental control genes. In vivo studies have indicated that the Drosophila segmentation gene fushi tarazu (ftz) directly or indirectly autoregulates its...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356804a0
更新日期:1992-04-30 00:00:00
abstract::The contractile proteins of adult skeletal and cardiac muscle tissue are very similar. Some of these proteins are identical in amino acid sequence or differ only slightly. Various structural studies have shown that the heavy and light chains of myosin are also homologous in skeletal and cardiac muscles. In developing ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286731a0
更新日期:1980-08-14 00:00:00
abstract::Most of the progress in human culture has required the exploitation of energy resources. About 100 years ago, the major source of energy shifted from recent solar to fossil hydrocarbons, including liquid and gaseous petroleum. Technology has generally led to a greater use of hydrocarbon fuels for most human activities...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02130
更新日期:2003-11-20 00:00:00
abstract::A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsible for its oncogenicit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353078a0
更新日期:1991-09-05 00:00:00
abstract::The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363166a0
更新日期:1993-05-13 00:00:00
abstract::Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02339
更新日期:2004-02-26 00:00:00
abstract::Gradual accumulation of evidence is thought to be fundamental for decision-making, and its neural correlates have been found in several brain regions. Here we develop a generalizable method to measure tuning curves that specify the relationship between neural responses and mentally accumulated evidence, and apply it t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14066
更新日期:2015-04-09 00:00:00