abstract：:A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...

journal_title：Nature

authors： Vogel AB,Kanevsky I,Che Y,Swanson KA,Muik A,Vormehr M,Kranz LM,Walzer KC,Hein S,Güler A,Loschko J,Maddur MS,Ota-Setlik A,Tompkins K,Cole J,Lui BG,Ziegenhals T,Plaschke A,Eisel D,Dany SC,Fesser S,Erbar S,Bates

更新日期：2021-02-01 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：:Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...

journal_title：Nature

authors： Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson K

更新日期：2021-01-20 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutralizing activity that can protect against infection in animal models1,2. Antibody ...

journal_title：Nature

authors： Gaebler C,Wang Z,Lorenzi JCC,Muecksch F,Finkin S,Tokuyama M,Cho A,Jankovic M,Schaefer-Babajew D,Oliveira TY,Cipolla M,Viant C,Barnes CO,Bram Y,Breton G,Hägglöf T,Mendoza P,Hurley A,Turroja M,Gordon K,Millard KG,

更新日期：2021-01-18 00:00:00

abstract：:Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3. Here, using an...

journal_title：Nature

authors： Chelmicki T,Roger E,Teissandier A,Dura M,Bonneville L,Rucli S,Dossin F,Fouassier C,Lameiras S,Bourc'his D

更新日期：2021-01-13 00:00:00

abstract：:Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...

journal_title：Nature

authors： Bongioanni A,Folloni D,Verhagen L,Sallet J,Klein-Flügge MC,Rushworth MFS

更新日期：2021-01-06 00:00:00

abstract：:Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...

journal_title：Nature

authors： Lau JA,Chen L,Choudhury A,Schwarzer D,Verma VB,Wodtke AM

更新日期：2021-01-01 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...

journal_title：Nature

authors： Hamazaki N,Kyogoku H,Araki H,Miura F,Horikawa C,Hamada N,Shimamoto S,Hikabe O,Nakashima K,Kitajima TS,Ito T,Leitch HG,Hayashi K

更新日期：2021-01-01 00:00:00

abstract：:Reinforcement learning models postulate that neurons that release dopamine encode information about action and action outcome, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release1. Dopamine is thought to guide learning via dynamic and differential modulation of protein ki...

journal_title：Nature

authors： Lee SJ,Lodder B,Chen Y,Patriarchi T,Tian L,Sabatini BL

更新日期：2020-12-23 00:00:00

abstract：:As countries in Europe gradually relaxed lockdown restrictions after the first wave, test-trace-isolate strategies became critical to maintain the incidence of coronavirus disease 2019 (COVID-19) at low levels1,2. Reviewing their shortcomings can provide elements to consider in light of the second wave that is current...

journal_title：Nature

authors： Pullano G,Di Domenico L,Sabbatini CE,Valdano E,Turbelin C,Debin M,Guerrisi C,Kengne-Kuetche C,Souty C,Hanslik T,Blanchon T,Boëlle PY,Figoni J,Vaux S,Campèse C,Bernard-Stoecklin S,Colizza V

更新日期：2020-12-21 00:00:00

abstract：:Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events1-3. However, there is limited understanding of the mechanisms by which experience drives circuit reorganization to establish a network of Fos-activated cells. It i...

journal_title：Nature

authors： Yap EL,Pettit NL,Davis CP,Nagy MA,Harmin DA,Golden E,Dagliyan O,Lin C,Rudolph S,Sharma N,Griffith EC,Harvey CD,Greenberg ME

更新日期：2020-12-09 00:00:00

abstract：:The halo of the Milky Way provides a laboratory to study the properties of the shocked hot gas that is predicted by models of galaxy formation. There is observational evidence of energy injection into the halo from past activity in the nucleus of the Milky Way1-4; however, the origin of this energy (star formation or ...

journal_title：Nature

authors： Predehl P,Sunyaev RA,Becker W,Brunner H,Burenin R,Bykov A,Cherepashchuk A,Chugai N,Churazov E,Doroshenko V,Eismont N,Freyberg M,Gilfanov M,Haberl F,Khabibullin I,Krivonos R,Maitra C,Medvedev P,Merloni A,Nandra K,N

更新日期：2020-12-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory respons...

journal_title：Nature

authors： Carvelli J,Demaria O,Vély F,Batista L,Chouaki Benmansour N,Fares J,Carpentier S,Thibult ML,Morel A,Remark R,André P,Represa A,Piperoglou C,Explore COVID-19 IPH group.,Explore COVID-19 Marseille Immunopole group.,Cordier PY

更新日期：2020-12-01 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia caused by severe ac...

journal_title：Nature

authors： Salahudeen AA,Choi SS,Rustagi A,Zhu J,van Unen V,de la O SM,Flynn RA,Margalef-Català M,Santos AJM,Ju J,Batish A,Usui T,Zheng GXY,Edwards CE,Wagar LE,Luca V,Anchang B,Nagendran M,Nguyen K,Hart DJ,Terry JM,Belgrad

更新日期：2020-12-01 00:00:00

abstract：:The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...

journal_title：Nature

authors： Ruan Z,Osei-Owusu J,Du J,Qiu Z,Lü W

更新日期：2020-12-01 00:00:00

abstract：:How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the developing heart, the myocardium transitions from a simple epithelium to an intricate tissue that consists of distinct layers: the outer compact and inner trabecular layers. Defects in this p...

journal_title：Nature

authors： Priya R,Allanki S,Gentile A,Mansingh S,Uribe V,Maischein HM,Stainier DYR

更新日期：2020-12-01 00:00:00

abstract：:Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...

journal_title：Nature

authors： Koning AA,Perales KM,Fluet-Chouinard E,McIntyre PB

更新日期：2020-12-01 00:00:00

abstract：:The gut microbiota influences development1-3 and homeostasis4-7 of the mammalian immune system, and is associated with human inflammatory8 and immune diseases9,10 as well as responses to immunotherapy11-14. Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in ...

journal_title：Nature

authors： Schluter J,Peled JU,Taylor BP,Markey KA,Smith M,Taur Y,Niehus R,Staffas A,Dai A,Fontana E,Amoretti LA,Wright RJ,Morjaria S,Fenelus M,Pessin MS,Chao NJ,Lew M,Bohannon L,Bush A,Sung AD,Hohl TM,Perales MA,van den

更新日期：2020-12-01 00:00:00

abstract：:Constructing agents with planning capabilities has long been one of the main challenges in the pursuit of artificial intelligence. Tree-based planning methods have enjoyed huge success in challenging domains, such as chess1 and Go2, where a perfect simulator is available. However, in real-world problems, the dynamics ...

journal_title：Nature

authors： Schrittwieser J,Antonoglou I,Hubert T,Simonyan K,Sifre L,Schmitt S,Guez A,Lockhart E,Hassabis D,Graepel T,Lillicrap T,Silver D

更新日期：2020-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Cai W,Ng B,Geng T,Wu L,Santoso A,McPhaden MJ

更新日期：2020-12-01 00:00:00

abstract：:Growing populations and agricultural intensification have led to raised riverine nitrogen (N) loads, widespread oxygen depletion in coastal zones (coastal hypoxia)1 and increases in the incidence of algal blooms.Although recent work has suggested that individual wetlands have the potential to improve water quality2-9,...

journal_title：Nature

authors： Cheng FY,Van Meter KJ,Byrnes DK,Basu NB

更新日期：2020-12-01 00:00:00

abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

journal_title：Nature

authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

更新日期：2020-11-01 00:00:00

abstract：:Fast radio bursts are mysterious millisecond-duration transients prevalent in the radio sky. Rapid accumulation of data in recent years has facilitated an understanding of the underlying physical mechanisms of these events. Knowledge gained from the neighbouring fields of gamma-ray bursts and radio pulsars has also of...

journal_title：Nature

authors： Zhang B

更新日期：2020-11-01 00:00:00

abstract：:Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...

journal_title：Nature

authors： Ameismeier M,Zemp I,van den Heuvel J,Thoms M,Berninghausen O,Kutay U,Beckmann R

更新日期：2020-11-01 00:00:00

abstract：:The oxygen evolution reaction has an important role in many alternative-energy schemes because it supplies the protons and electrons required for converting renewable electricity into chemical fuels1-3. Electrocatalysts accelerate the reaction by facilitating the required electron transfer4, as well as the formation a...

journal_title：Nature

authors： Nong HN,Falling LJ,Bergmann A,Klingenhof M,Tran HP,Spöri C,Mom R,Timoshenko J,Zichittella G,Knop-Gericke A,Piccinin S,Pérez-Ramírez J,Cuenya BR,Schlögl R,Strasser P,Teschner D,Jones TE

更新日期：2020-11-01 00:00:00

abstract：:Soft machines are a promising design paradigm for human-centric devices1,2 and systems required to interact gently with their environment3,4. To enable soft machines to respond intelligently to their surroundings, compliant sensory feedback mechanisms are needed. Specifically, soft alternatives to strain gauges-with h...

journal_title：Nature

authors： Araromi OA,Graule MA,Dorsey KL,Castellanos S,Foster JR,Hsu WH,Passy AE,Vlassak JJ,Weaver JC,Walsh CJ,Wood RJ

更新日期：2020-11-01 00:00:00

abstract：:Expansion of anthropogenic noise and night lighting across our planet1,2 is of increasing conservation concern3-6. Despite growing knowledge of physiological and behavioural responses to these stimuli from single-species and local-scale studies, whether these pollutants affect fitness is less clear, as is how and why ...

journal_title：Nature

authors： Senzaki M,Barber JR,Phillips JN,Carter NH,Cooper CB,Ditmer MA,Fristrup KM,McClure CJW,Mennitt DJ,Tyrrell LP,Vukomanovic J,Wilson AA,Francis CD

更新日期：2020-11-01 00:00:00

abstract：:The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse applications in quantum computing and communications1. However, fluorescent nanodiamonds also have attractive properties for in vitro biosensing, including brightness2, low cost3 and selective manipulation of their emission4. Nanoparticl...

journal_title：Nature

authors： Miller BS,Bezinge L,Gliddon HD,Huang D,Dold G,Gray ER,Heaney J,Dobson PJ,Nastouli E,Morton JJL,McKendry RA

更新日期：2020-11-01 00:00:00

abstract：:Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly und...

journal_title：Nature

authors： Afek A,Shi H,Rangadurai A,Sahay H,Senitzki A,Xhani S,Fang M,Salinas R,Mielko Z,Pufall MA,Poon GMK,Haran TE,Schumacher MA,Al-Hashimi HM,Gordân R

更新日期：2020-11-01 00:00:00

abstract：:Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...

journal_title：Nature

authors： Rajewsky N,Almouzni G,Gorski SA,Aerts S,Amit I,Bertero MG,Bock C,Bredenoord AL,Cavalli G,Chiocca S,Clevers H,De Strooper B,Eggert A,Ellenberg J,Fernández XM,Figlerowicz M,Gasser SM,Hubner N,Kjems J,Knoblich JA,Kra

更新日期：2020-11-01 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA1. After binding DNA, cGAS synthesizes the messenger 2'3'-cyclic GMP-AMP (cGAMP)2-4, which triggers cell-autonomous defence and the production of type I interferons and pro-inflammatory cytokines via the activation of STING5. In addit...

journal_title：Nature

authors： Michalski S,de Oliveira Mann CC,Stafford CA,Witte G,Bartho J,Lammens K,Hornung V,Hopfner KP

更新日期：2020-11-01 00:00:00

abstract：:Fast radio bursts (FRBs) are millisecond-duration radio transients1,2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres3-5 or relativistic shocks far from the central energy source6-8. Detailed polarization observations may help us t...

journal_title：Nature

authors： Luo R,Wang BJ,Men YP,Zhang CF,Jiang JC,Xu H,Wang WY,Lee KJ,Han JL,Zhang B,Caballero RN,Chen MZ,Chen XL,Gan HQ,Guo YJ,Hao LF,Huang YX,Jiang P,Li H,Li J,Li ZX,Luo JT,Pan J,Pei X,Qian L,Sun JH,Wang M,Wa

更新日期：2020-10-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the h...

journal_title：Nature

authors： Bao EL,Nandakumar SK,Liao X,Bick AG,Karjalainen J,Tabaka M,Gan OI,Havulinna AS,Kiiskinen TTJ,Lareau CA,de Lapuente Portilla AL,Li B,Emdin C,Codd V,Nelson CP,Walker CJ,Churchhouse C,de la Chapelle A,Klein DE,Nilsson

更新日期：2020-10-01 00:00:00

abstract：:Neuromorphic computing draws inspiration from the brain to provide computing technology and architecture with the potential to drive the next wave of computer engineering1-13. Such brain-inspired computing also provides a promising platform for the development of artificial general intelligence14,15. However, unlike c...

journal_title：Nature

authors： Zhang Y,Qu P,Ji Y,Zhang W,Gao G,Wang G,Song S,Li G,Chen W,Zheng W,Chen F,Pei J,Zhao R,Zhao M,Shi L

更新日期：2020-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Apffel B,Novkoski F,Eddi A,Fort E

更新日期：2020-10-01 00:00:00

abstract：:Joining dissimilar materials such as plastics and metals in engineered structures remains a challenge1. Mechanical fastening, conventional welding and adhesive bonding are examples of techniques currently used for this purpose, but each of these methods presents its own set of problems2 such as formation of stress con...

journal_title：Nature

authors： Rivera J,Hosseini MS,Restrepo D,Murata S,Vasile D,Parkinson DY,Barnard HS,Arakaki A,Zavattieri P,Kisailus D

更新日期：2020-10-01 00:00:00

abstract：:An inductor, one of the most fundamental circuit elements in modern electronic devices, generates a voltage proportional to the time derivative of the input current1. Conventional inductors typically consist of a helical coil and induce a voltage as a counteraction to time-varying magnetic flux penetrating the coil, f...

journal_title：Nature

authors： Yokouchi T,Kagawa F,Hirschberger M,Otani Y,Nagaosa N,Tokura Y

更新日期：2020-10-01 00:00:00