A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.

abstract：:Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomo...

journal_title：Nature

authors： Constantino JN,Kennon-McGill S,Weichselbaum C,Marrus N,Haider A,Glowinski AL,Gillespie S,Klaiman C,Klin A,Jones W

更新日期：2017-07-20 00:00:00

abstract：:In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...

journal_title：Nature

authors： Huxter J,Burgess N,O'Keefe J

更新日期：2003-10-23 00:00:00

abstract：:p97 is a 97,000 molecular weight cell-surface glycoprotein, which is present in human melanomas but in only trace amounts in normal adult tissues. Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin. Reports that the genes for the transferrin recepto...

journal_title：Nature

authors： Plowman GD,Brown JP,Enns CA,Schröder J,Nikinmaa B,Sussman HH,Hellström KE,Hellström I

更新日期：1983-05-05 00:00:00

abstract：:The geometry and dimensions of branched structures such as blood vessels or airways are important factors in determining the efficiency of physiological processes. It has been shown that fractal trees can be space filling and can ensure minimal dissipation. The bronchial tree of most mammalian lungs is a good example ...

journal_title：Nature

authors： Mauroy B,Filoche M,Weibel ER,Sapoval B

更新日期：2004-02-12 00:00:00

abstract：:The identification of properties that contribute to the persistence and resilience of ecosystems despite climate change constitutes a research priority of global relevance. Here we present a novel, empirical approach to assess the relative sensitivity of ecosystems to climate variability, one property of resilience th...

journal_title：Nature

authors： Seddon AW,Macias-Fauria M,Long PR,Benz D,Willis KJ

更新日期：2016-03-10 00:00:00

abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

journal_title：Nature

authors： Noel JP,Hamm HE,Sigler PB

更新日期：1993-12-16 00:00:00

abstract：:The nature of ultrahigh-energy cosmic rays (UHECRs) at energies >10(20) eV remains a mystery. They are likely to be of extragalactic origin, but should be absorbed within approximately 50 Mpc through interactions with the cosmic microwave background. As there are no sufficiently powerful accelerators within this dista...

journal_title：Nature

authors： Falcke H,Apel WD,Badea AF,Bähren L,Bekk K,Bercuci A,Bertaina M,Biermann PL,Blümer J,Bozdog H,Brancus IM,Buitink S,Brüggemann M,Buchholz P,Butcher H,Chiavassa A,Daumiller K,de Bruyn AG,de Vos CM,Di Pierro F,Doll P

更新日期：2005-05-19 00:00:00

abstract：:Type III collagen is often found in the same tissues as type I collagen, yet the function and nature of the fibrils formed by the two collagens differ markedly. To understand the evolutionary history of the collagen gene family in more detail, we isolated the gene for type III collagen and compared its structure with ...

journal_title：Nature

authors： Yamada Y,Liau G,Mudryj M,Obici S,de Crombrugghe B

更新日期：1984-07-26 00:00:00

abstract：:Adenosine is a potent modulator of transmitter release at a variety of synapses. The adenosine A1 receptor is assumed to reside in presynaptic terminals and to function as a negative autoreceptor. How adenosine reduces transmitter release is uncertain; it may reduce the calcium influx during nerve terminal depolarizat...

journal_title：Nature

authors： Yawo H,Chuhma N

更新日期：1993-09-16 00:00:00

abstract：:Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...

journal_title：Nature

authors： Ives AR,Cardinale BJ

更新日期：2004-05-13 00:00:00

abstract：:The maturation of RAS GTPases and approximately 200 other cellular CAAX proteins involves three enzymatic steps: addition of a farnesyl or geranylgeranyl prenyl lipid to the cysteine (C) in the C-terminal CAAX motif, proteolytic cleavage of the AAX residues and methylation of the exposed prenylcysteine residue at its ...

journal_title：Nature

authors： Diver MM,Pedi L,Koide A,Koide S,Long SB

更新日期：2018-01-25 00:00:00

abstract：:Morphogens act in developing tissues to control the spatial arrangement of cellular differentiation. The activity of a morphogen has generally been viewed as a concentration-dependent response to a diffusible signal, but the duration of morphogen signalling can also affect cellular responses. One such example is the m...

journal_title：Nature

authors： Dessaud E,Yang LL,Hill K,Cox B,Ulloa F,Ribeiro A,Mynett A,Novitch BG,Briscoe J

更新日期：2007-11-29 00:00:00

abstract：:Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses. Human immunodeficiency virus 1 (HIV-1) fails to transduce dendritic cells and has a reduced ability to tra...

journal_title：Nature

authors： Hrecka K,Hao C,Gierszewska M,Swanson SK,Kesik-Brodacka M,Srivastava S,Florens L,Washburn MP,Skowronski J

更新日期：2011-06-29 00:00:00

abstract：:Although stars form from clouds of gas and dust, there are insignificant amounts of gas around ordinary (Sun-like) stars. This suggests that hydrogen and helium, the primary constituents of planets such as Jupiter and Saturn, are not easily retained in orbit as a star matures. The gas-giant planets in the Solar System...

journal_title：Nature

authors： Zuckerman B,Forveille T,Kastner JH

更新日期：1995-02-09 00:00:00

abstract：:A fundamental tenet of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide a teaching signal that promotes the gradual adaptation of movements. Data from several forms of motor learning provide support for this tenet. In pavlovian eyelid conditioning, for example, where a...

journal_title：Nature

authors： Medina JF,Nores WL,Mauk MD

更新日期：2002-03-21 00:00:00

abstract：:Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...

journal_title：Nature

authors： Hart J Jr,Gordon B

更新日期：1992-09-03 00:00:00

abstract：:Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of prote...

journal_title：Nature

authors： Shinohara T,Piatigorsky J

更新日期：1977-12-01 00:00:00

abstract：:Scientific theories of how subduction and plate tectonics began on Earth--and what the tectonic structure of Earth was before this--remain enigmatic and contentious. Understanding viable scenarios for the onset of subduction and plate tectonics is hampered by the fact that subduction initiation processes must have bee...

journal_title：Nature

authors： Gerya TV,Stern RJ,Baes M,Sobolev SV,Whattam SA

更新日期：2015-11-12 00:00:00

abstract：:For plants, the sensing of light in the environment is as important as vision is for animals. Fluctuations in light can be crucial to competition and survival. One way plants sense light is through the phytochromes, a small family of diverse photochromic protein photoreceptors whose origins have been traced to the pho...

journal_title：Nature

authors： Smith H

更新日期：2000-10-05 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...

journal_title：Nature

authors： Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

更新日期：2002-03-28 00:00:00

abstract：:Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...

journal_title：Nature

authors： Ferraro FR,Dalessandro E,Mucciarelli A,Beccari G,Rich RM,Origlia L,Lanzoni B,Rood RT,Valenti E,Bellazzini M,Ransom SM,Cocozza G

更新日期：2009-11-26 00:00:00

abstract：:Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...

journal_title：Nature

authors： Lo I,Denef VJ,Verberkmoes NC,Shah MB,Goltsman D,DiBartolo G,Tyson GW,Allen EE,Ram RJ,Detter JC,Richardson P,Thelen MP,Hettich RL,Banfield JF

更新日期：2007-03-29 00:00:00

abstract：:Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...

journal_title：Nature

authors： Sakamaki T,Suzuki A,Ohtani E

更新日期：2006-01-12 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：:Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome. The SRP-riboso...

journal_title：Nature

authors： Janda CY,Li J,Oubridge C,Hernández H,Robinson CV,Nagai K

更新日期：2010-05-27 00:00:00

abstract：:Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to vertebrates. However, a problem...

journal_title：Nature

authors： Griffin AS,West SA,Buckling A

更新日期：2004-08-26 00:00:00

abstract：:Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The 'Phillips' mechanism is widely held as the paradig...

journal_title：Nature

authors： Vocadlo DJ,Davies GJ,Laine R,Withers SG

更新日期：2001-08-23 00:00:00

abstract：:The Amazon rainforest plays a crucial role in the climate system, helping to drive atmospheric circulations in the tropics by absorbing energy and recycling about half of the rainfall that falls on it. This region (Amazonia) is also estimated to contain about one-tenth of the total carbon stored in land ecosystems, an...

journal_title：Nature

authors： Cox PM,Harris PP,Huntingford C,Betts RA,Collins M,Jones CD,Jupp TE,Marengo JA,Nobre CA

更新日期：2008-05-08 00:00:00

abstract：:Serious, and occasionally fatal, anaphylactic-like (anaphylactoid) reactions may occur when a patient is exposed to a drug for the first time. Apart from the penicillins, nothing is known of the nature of antigenic or sensitizing drug determinants and, as yet, there is no evidence for the involvement of IgE antibodies...

journal_title：Nature

authors： Baldo BA,Fisher MM

更新日期：1983-11-17 00:00:00