Increasing risk of Amazonian drought due to decreasing aerosol pollution.

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue. Sister chromatids may be distinguished and segregated nonrandomly in asymmetrically dividing stem cells, although the underlying mechanism and the purpose it may serve remain elusive. Here...

journal_title：Nature

authors： Yadlapalli S,Yamashita YM

更新日期：2013-06-13 00:00:00

abstract：:An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...

journal_title：Nature

authors： Geisow MJ,Burgoyne RD

更新日期：1983-02-03 00:00:00

abstract：:Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...

journal_title：Nature

authors： Rawat UB,Zavialov AV,Sengupta J,Valle M,Grassucci RA,Linde J,Vestergaard B,Ehrenberg M,Frank J

更新日期：2003-01-02 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:Transition-metal perovskite oxides exhibit a wide range of extraordinary but imperfectly understood phenomena. The best known examples are high-temperature superconductivity in copper oxides, and colossal magnetoresistance in manganese oxides ('manganites'). All of these materials undergo a range of order-disorder tra...

journal_title：Nature

authors： Renner Ch,Aeppli G,Kim BG,Soh YA,Cheong SW

更新日期：2002-04-04 00:00:00

abstract：:Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...

journal_title：Nature

authors： Grivennikov SI,Wang K,Mucida D,Stewart CA,Schnabl B,Jauch D,Taniguchi K,Yu GY,Osterreicher CH,Hung KE,Datz C,Feng Y,Fearon ER,Oukka M,Tessarollo L,Coppola V,Yarovinsky F,Cheroutre H,Eckmann L,Trinchieri G,Karin M

更新日期：2012-11-08 00:00:00

abstract：:Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substant...

journal_title：Nature

authors： Capron M,Capron A,Goetzl EJ,Austen KF

更新日期：1981-01-01 00:00:00

abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...

journal_title：Nature

authors： Yu W,Gius D,Onyango P,Muldoon-Jacobs K,Karp J,Feinberg AP,Cui H

更新日期：2008-01-10 00:00:00

abstract：:Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...

journal_title：Nature

authors： Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her

更新日期：2015-11-19 00:00:00

abstract：:Indirect-benefit models of sexual selection assert that females gain heritable offspring advantages through a mating bias for males of superior genetic quality. This has generally been tested by associating a simple morphological quality indicator (for example, bird tail length) with offspring viability. However, sele...

journal_title：Nature

authors： Fedorka KM,Mousseau TA

更新日期：2004-05-06 00:00:00

abstract：:The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...

journal_title：Nature

authors： Boriack-Sjodin PA,Margarit SM,Bar-Sagi D,Kuriyan J

更新日期：1998-07-23 00:00:00

abstract：:During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle. In the spindle, kinetochore microtubules have their plus ends embedded in the kinetochore and their minus ends at the spindle pole. Two models have been proposed to account for the movement of chromatids during...

journal_title：Nature

authors： Rogers GC,Rogers SL,Schwimmer TA,Ems-McClung SC,Walczak CE,Vale RD,Scholey JM,Sharp DJ

更新日期：2004-01-22 00:00:00

abstract：:Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...

journal_title：Nature

authors： Kikeri D,Sun A,Zeidel ML,Hebert SC

更新日期：1989-06-08 00:00:00

abstract：:The origins of the building blocks of the Solar System can be studied using the isotopic composition of early planetary and meteoritic material. Oxygen isotopes in planetary materials show variations at the per cent level that are not related to the mass of the isotopes; rather, they result from the mixture of compone...

journal_title：Nature

authors： Aléon J,Robert F,Duprat J,Derenne S

更新日期：2005-09-15 00:00:00

abstract：:Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...

journal_title：Nature

authors： Jordan NV,Bardia A,Wittner BS,Benes C,Ligorio M,Zheng Y,Yu M,Sundaresan TK,Licausi JA,Desai R,O'Keefe RM,Ebright RY,Boukhali M,Sil S,Onozato ML,Iafrate AJ,Kapur R,Sgroi D,Ting DT,Toner M,Ramaswamy S,Haas W,Mah

更新日期：2016-09-01 00:00:00

abstract：:Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct out...

journal_title：Nature

authors： Djebali S,Davis CA,Merkel A,Dobin A,Lassmann T,Mortazavi A,Tanzer A,Lagarde J,Lin W,Schlesinger F,Xue C,Marinov GK,Khatun J,Williams BA,Zaleski C,Rozowsky J,Röder M,Kokocinski F,Abdelhamid RF,Alioto T,Antoshechkin

更新日期：2012-09-06 00:00:00

abstract：:Sex-determination genes are among the most fluid features of the genome in many groups of animals. In some taxa the master sex-determining gene moves frequently between chromosomes, whereas in other taxa different genes have been recruited to determine the sex of the zygotes. There is a well developed theory for the o...

journal_title：Nature

authors： van Doorn GS,Kirkpatrick M

更新日期：2007-10-18 00:00:00

abstract：:The recent discovery of a pterosaur egg with embryonic skeleton and soft tissues from the Yixian Formation confirmed that the flying pterosaurs were oviparous. Here we describe another pterosaur egg whose exquisite preservation indicates that the shell structure was soft and leathery. ...

journal_title：Nature

authors： Ji Q,Ji SA,Cheng YN,You HL,Lü JC,Liu YQ,Yuan CX

更新日期：2004-12-02 00:00:00

abstract：:Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...

journal_title：Nature

authors： Zipfel C,Oldroyd GE

更新日期：2017-03-15 00:00:00

abstract：:In vitro reconstitution of active ribulose bisphosphate carboxylase (Rubisco) from unfolded polypeptides is facilitated by the molecular chaperones: chaperonin-60 from Escherichia coli (groEL), yeast mitochondria (hsp60) or chloroplasts (Rubisco sub-unit-binding protein), together with chaperonin-10 from E. coli (groE...

journal_title：Nature

authors： Goloubinoff P,Christeller JT,Gatenby AA,Lorimer GH

更新日期：1989-12-21 00:00:00

abstract：:X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D. melanogaster, but are randomly distributed in the genome of Anopheles gambiae. In direct global profiling experiments using ...

journal_title：Nature

authors： Sturgill D,Zhang Y,Parisi M,Oliver B

更新日期：2007-11-08 00:00:00

abstract：:The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, ma...

journal_title：Nature

authors： Pabo CO,Lewis M

更新日期：1982-07-29 00:00:00

abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...

journal_title：Nature

authors： Rauner N,Meuris M,Zoric M,Tiller JC

更新日期：2017-03-16 00:00:00

abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

journal_title：Nature

authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

更新日期：1995-10-12 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK-3beta) has integral roles in a variety of biological processes, including development, diabetes, and the progression of Alzheimer's disease. As such, a thorough understanding of GSK-3beta function will have a broad impact on human biology and therapeutics. Because GSK-3beta interact...

journal_title：Nature

authors： Liu KJ,Arron JR,Stankunas K,Crabtree GR,Longaker MT

更新日期：2007-03-01 00:00:00

abstract：:Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and by the Voyager and Cassini spacecraft. The most puzzling aspects include the origin of the molecular nitrogen and methane in its atmosphere, and the mechanism(s) by which methane is maintained in the face of rapid destruct...

journal_title：Nature

authors： Niemann HB,Atreya SK,Bauer SJ,Carignan GR,Demick JE,Frost RL,Gautier D,Haberman JA,Harpold DN,Hunten DM,Israel G,Lunine JI,Kasprzak WT,Owen TC,Paulkovich M,Raulin F,Raaen E,Way SH

更新日期：2005-12-08 00:00:00

abstract：:beta Pictoris (beta Pic) is a main-sequence star with an edge-on dust disk that might represent a state of the early Solar System. The dust does not seem to be a remnant from the original protoplanetary disk, but rather is thought to have been generated from large bodies like planetesimals and/or comets. The history a...

journal_title：Nature

authors： Okamoto YK,Kataza H,Honda M,Yamashita T,Onaka T,Watanabe J,Miyata T,Sako S,Fujiyoshi T,Sakon I

更新日期：2004-10-07 00:00:00

abstract：:Some surprising facts about the most productive institutions emerge when Japanese life-science research is subject to a novel type of assessment. ...

journal_title：Nature

authors： Yamazaki S

更新日期：1994-11-10 00:00:00

abstract：:Grid cells in the entorhinal cortex of freely moving rats provide a strikingly periodic representation of self-location which is indicative of very specific computational mechanisms. However, the existence of grid cells in humans and their distribution throughout the brain are unknown. Here we show that the preferred ...

journal_title：Nature

authors： Doeller CF,Barry C,Burgess N

更新日期：2010-02-04 00:00:00