Demasculinization of X chromosomes in the Drosophila genus.

abstract：:The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...

journal_title：Nature

authors： Pätzold M,Häusler B,Bird MK,Tellmann S,Mattei R,Asmar SW,Dehant V,Eidel W,Imamura T,Simpson RA,Tyler GL

更新日期：2007-11-29 00:00:00

abstract：:Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are translated to micrometre-scale macroscopic properties are not well understood. Here we show that interactions between diverse synthetic, multivalent macromolecules (includ...

journal_title：Nature

authors： Li P,Banjade S,Cheng HC,Kim S,Chen B,Guo L,Llaguno M,Hollingsworth JV,King DS,Banani SF,Russo PS,Jiang QX,Nixon BT,Rosen MK

更新日期：2012-03-07 00:00:00

abstract：:Polycomb and trithorax group (PcG and trxG) proteins maintain silent and active transcriptional states, respectively, throughout development. In Drosophila, PcG and trxG proteins associate with DNA regions named Polycomb and trithorax response elements (PRE and TRE), but the mechanisms of recruitment are unknown. We p...

journal_title：Nature

authors： Déjardin J,Rappailles A,Cuvier O,Grimaud C,Decoville M,Locker D,Cavalli G

更新日期：2005-03-24 00:00:00

abstract：:Lymphocyte function-associated antigen-1 (LFA-1) is a heterodimer composed of an alpha and beta chain that is expressed on the surface of most leukocytes and is an essential molecule for adhesion reactions between cells participating in the immune response. A putative ligand for LFA-1 is the intercellular adhesion mol...

journal_title：Nature

authors： van Noesel C,Miedema F,Brouwer M,de Rie MA,Aarden LA,van Lier RA

更新日期：1988-06-30 00:00:00

abstract：:Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...

journal_title：Nature

authors： Delord T,Huillery P,Nicolas L,Hétet G

更新日期：2020-04-01 00:00:00

abstract：:Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...

journal_title：Nature

authors： Moses K,Ellis MC,Rubin GM

更新日期：1989-08-17 00:00:00

abstract：:The dispute among federal agencies over regulation of commercial biotechnology has been addressed in the Federal Register by the Office of Science and Technology Policy (OSTP), which says the Recombinant DNA Advisory Committee of the National Institutes of Health should continue to oversee biomedical research in this ...

journal_title：Nature

authors： Beardsley T

更新日期：1985-01-10 00:00:00

abstract：:During intracellular Ca2+ signalling mitochondria accumulate significant amounts of Ca2+ from the cytosol. Mitochondrial Ca2+ uptake controls the rate of energy production, shapes the amplitude and spatio-temporal patterns of intracellular Ca2+ signals, and is instrumental to cell death. This Ca2+ uptake is undertaken...

journal_title：Nature

authors： Kirichok Y,Krapivinsky G,Clapham DE

更新日期：2004-01-22 00:00:00

abstract：:The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and...

journal_title：Nature

authors： Carmeliet P

更新日期：2005-12-15 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:Over the past 50 years there has been much speculation about the energetic cost of swimming and wave-riding by dolphins. When aligned properly in front of the bow of moving ships in the stern wake of small boats, on wind waves, and even in the wake of larger cetaceans, the animals appear to move effortlessly through t...

journal_title：Nature

authors： Williams TM,Friedl WA,Fong ML,Yamada RM,Sedivy P,Haun JE

更新日期：1992-02-27 00:00:00

abstract：:Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regula...

journal_title：Nature

authors： Roychoudhuri R,Hirahara K,Mousavi K,Clever D,Klebanoff CA,Bonelli M,Sciumè G,Zare H,Vahedi G,Dema B,Yu Z,Liu H,Takahashi H,Rao M,Muranski P,Crompton JG,Punkosdy G,Bedognetti D,Wang E,Hoffmann V,Rivera J,Marincol

更新日期：2013-06-27 00:00:00

abstract：:The halo of the Milky Way provides a laboratory to study the properties of the shocked hot gas that is predicted by models of galaxy formation. There is observational evidence of energy injection into the halo from past activity in the nucleus of the Milky Way1-4; however, the origin of this energy (star formation or ...

journal_title：Nature

authors： Predehl P,Sunyaev RA,Becker W,Brunner H,Burenin R,Bykov A,Cherepashchuk A,Chugai N,Churazov E,Doroshenko V,Eismont N,Freyberg M,Gilfanov M,Haberl F,Khabibullin I,Krivonos R,Maitra C,Medvedev P,Merloni A,Nandra K,N

更新日期：2020-12-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies deta...

journal_title：Nature

authors： Cram DS,Song B,Trounson AO

更新日期：2007-11-22 00:00:00

abstract：:Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interr...

journal_title：Nature

authors： Khodadoust MS,Olsson N,Wagar LE,Haabeth OA,Chen B,Swaminathan K,Rawson K,Liu CL,Steiner D,Lund P,Rao S,Zhang L,Marceau C,Stehr H,Newman AM,Czerwinski DK,Carlton VE,Moorhead M,Faham M,Kohrt HE,Carette J,Green MR

更新日期：2017-03-30 00:00:00

abstract：:In adult animals, sensory neurons innervating the skin are phenotypically diverse. We have now investigated whether nerve growth factor (NGF) has a physiological role in the development of this diversity. We gave antisera against NGF to rats from postnatal day 1 (PND 1) to adulthood (5 weeks). We found a virtually com...

journal_title：Nature

authors： Ritter AM,Lewin GR,Kremer NE,Mendell LM

更新日期：1991-04-11 00:00:00

abstract：: ...

journal_title：Nature

authors： Butchart SHM,Clements A,Gibbons DW

更新日期：2019-02-01 00:00:00

abstract：:Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...

journal_title：Nature

authors： Aarts MG,Dirkse WG,Stiekema WJ,Pereira A

更新日期：1993-06-24 00:00:00

abstract：:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly e...

journal_title：Nature

authors： Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P

更新日期：1996-03-14 00:00:00

abstract：:The University of California at Berkeley has announced the postponement of a planned experiment involving the field testing of bacteria genetically engineered to reduce frost damage to crops. The action came after Jeremy Rifkin, who had earlier filed suit against the National Institutes of Health after its Recombinan...

journal_title：Nature

authors： Budiansky S

更新日期：1983-10-13 00:00:00

abstract：:Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...

journal_title：Nature

authors： Switzer WM,Salemi M,Shanmugam V,Gao F,Cong ME,Kuiken C,Bhullar V,Beer BE,Vallet D,Gautier-Hion A,Tooze Z,Villinger F,Holmes EC,Heneine W

更新日期：2005-03-17 00:00:00

abstract：:Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, ...

journal_title：Nature

authors： Tung CC,Lobo PA,Kimlicka L,Van Petegem F

更新日期：2010-11-25 00:00:00

abstract：:To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...

journal_title：Nature

authors： Helms JA,Schneider RA

更新日期：2003-05-15 00:00:00

abstract：: ...

journal_title：Nature

authors： Liao SE

更新日期：2018-11-01 00:00:00

abstract：:Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...

journal_title：Nature

authors： Straus DB,Walter WA,Gross CA

更新日期：1987-09-24 00:00:00

abstract：:'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...

journal_title：Nature

authors： Knutson HA,Charbonneau D,Allen LE,Fortney JJ,Agol E,Cowan NB,Showman AP,Cooper CS,Megeath ST

更新日期：2007-05-10 00:00:00

abstract：:Particle acceleration based on high intensity laser systems (a process known as laser-plasma acceleration) has achieved high quality particle beams that compare favourably with conventional acceleration techniques in terms of emittance, brightness and pulse duration. A long-term difficulty associated with laser-plasma...

journal_title：Nature

authors： Schwoerer H,Pfotenhauer S,Jäckel O,Amthor KU,Liesfeld B,Ziegler W,Sauerbrey R,Ledingham KW,Esirkepov T

更新日期：2006-01-26 00:00:00

abstract：:Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular remodelling, cardiac development and atherogenesis, but the mechanisms of transduction are poorly understood. Previous work showed that the conversion of integrins to a high-affinity state mediates a subset of shear responses, inclu...

journal_title：Nature

authors： Tzima E,Irani-Tehrani M,Kiosses WB,Dejana E,Schultz DA,Engelhardt B,Cao G,DeLisser H,Schwartz MA

更新日期：2005-09-15 00:00:00

abstract：:Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular-matrix ligands, transmitting forces and signals necessary for locomotion. Whether cells will migrate or not on a given substratum, and also their speed, depends on several variables related ...

journal_title：Nature

authors： Palecek SP,Loftus JC,Ginsberg MH,Lauffenburger DA,Horwitz AF

更新日期：1997-02-06 00:00:00