Abstract:
:Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies detailed in their paper provides supporting evidence that the chromosome complement of CRES-1 and CRES-2 was genetically identical to the male cell donor nucleus and that the mitochondrial DNA originated from different recipient oocytes. In this validation paper, we independently confirm that both stem cell lines were indeed derived by SCNT.
journal_name
Naturejournal_title
Natureauthors
Cram DS,Song B,Trounson AOdoi
10.1038/nature06456subject
Has Abstractpub_date
2007-11-22 00:00:00pages
E12-4issue
7169eissn
0028-0836issn
1476-4687pii
nature06456journal_volume
450pub_type
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