Abstract:
:Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking. KLF2-deficient (Klf2-/-) thymocytes show impaired expression of several receptors required for thymocyte emigration and peripheral trafficking, including the sphingosine-1-phosphate (S1P) receptor S1P1, CD62L and beta7 integrin. Furthermore, KLF2 both binds and transactivates the promoter for S1P1--a receptor that is critical for thymocyte egress and recirculation through peripheral lymphoid organs. Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues.
journal_name
Naturejournal_title
Natureauthors
Carlson CM,Endrizzi BT,Wu J,Ding X,Weinreich MA,Walsh ER,Wani MA,Lingrel JB,Hogquist KA,Jameson SCdoi
10.1038/nature04882subject
Has Abstractpub_date
2006-07-20 00:00:00pages
299-302issue
7100eissn
0028-0836issn
1476-4687pii
nature04882journal_volume
442pub_type
杂志文章相关文献
NATURE文献大全abstract::Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13664
更新日期:2014-11-06 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332085a0
更新日期:1988-03-03 00:00:00
abstract::In the course of synaptic transmission in the brain and periphery, acetylcholine receptors (AChRs) rapidly transduce a chemical signal into an electrical impulse. The speed of transduction is facilitated by rapid ACh association and dissociation, suggesting a binding site relatively non-selective for small cations. Se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07923
更新日期:2009-05-21 00:00:00
abstract::Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03341
更新日期:2005-03-17 00:00:00
abstract::The Southern Ocean houses a diverse and productive community of organisms. Unicellular eukaryotic diatoms are the main primary producers in this environment, where photosynthesis is limited by low concentrations of dissolved iron and large seasonal fluctuations in light, temperature and the extent of sea ice. How diat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20803
更新日期:2017-01-26 00:00:00
abstract::Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369571a0
更新日期:1994-06-16 00:00:00
abstract::Atrial extracts contain factors which induce potent natriuresis changes in renal haemodynamics, and relax pre-contracted vascular smooth muscle. Low-molecular-weight peptides which mimic these actions have now been purified by several groups, including ours (see accompanying paper), and higher-molecular-weight protein...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309719a0
更新日期:1984-06-21 00:00:00
abstract::Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-020-2715-9
更新日期:2020-11-01 00:00:00
abstract::Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35050141
更新日期:2000-12-21 00:00:00
abstract::Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15258
更新日期:2015-10-15 00:00:00
abstract::Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335815a0
更新日期:1988-10-27 00:00:00
abstract::Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23738
更新日期:1999-08-26 00:00:00
abstract::Analogous to the progression of events in the opiate receptor-enkaphalin area, the first reports that benzodiazepines have selective and specific high-affinity binding sites in brain have stimulated a search for the endogenous 'ligand' or substance that might normally act at these sites. Braestrup and co-workers have ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288609a0
更新日期:1980-12-11 00:00:00
abstract::Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332083a0
更新日期:1988-03-03 00:00:00
abstract::Defects in insulin signalling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes. MicroRNAs have been identified as a new class of regulatory molecules that influence many biological functions, including metabolism. However, the direct regulation of insul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10112
更新日期:2011-06-08 00:00:00
abstract::Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, howe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287451a0
更新日期:1980-10-02 00:00:00
abstract::NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01497
更新日期:2003-03-20 00:00:00
abstract::The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02245
更新日期:2004-01-29 00:00:00
abstract::There has been an increasing interest in the use of immobilized cells for the production of pharmaceuticals as well as for products such as high fructose syrup or ethanol. Some of these compounds are now produced on an industrial scale whereby the cells are used in a resting or growing state or in a nonviable form as ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/302543a0
更新日期:1983-04-07 00:00:00
abstract::The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04866
更新日期:2006-07-27 00:00:00
abstract::The long-term exchange of volatile species (such as water, carbon, nitrogen and the noble gases) between deep Earth and surface reservoirs controls the habitability of the Earth's surface. The present-day volatile budget of the mantle reflects the integrated history of outgassing and retention of primordial volatiles ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0388-4
更新日期:2018-08-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology1,2. The reciprocal interplay betwe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1130-6
更新日期:2019-05-01 00:00:00
abstract::A detailed description of the interactions between an antibody and its epitope is necessary to allow an understanding of the way in which antibodies bind to antigenic surfaces presented by foreign molecules. Ideally this should be done by analysis of crystal structures of antibody-antigen complexes, but so far only tw...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328731a0
更新日期:1987-08-20 00:00:00
abstract::Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11836
更新日期:2013-02-21 00:00:00
abstract::Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11032
更新日期:2012-04-18 00:00:00
abstract::Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional structure of a GABAAR, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13293
更新日期:2014-08-21 00:00:00
abstract::Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04352
更新日期:2006-01-12 00:00:00
abstract::Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35089076
更新日期:2001-08-16 00:00:00
abstract::Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13466
更新日期:2014-09-11 00:00:00
abstract::In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02058
更新日期:2003-10-23 00:00:00