beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity.

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with repetitive segments flanked by conserved non-repetitive domains. Spidroins are stored as a highly concentrated fluid dope. On silk formation, intermolecular interactions between repeat regions are established that provide st...

journal_title：Nature

authors： Askarieh G,Hedhammar M,Nordling K,Saenz A,Casals C,Rising A,Johansson J,Knight SD

更新日期：2010-05-13 00:00:00

abstract：:The mutation brachypodism (bp) alters the length and number of bones in the limbs of mice but spares the axial skeleton. It illustrates the importance of specific genes in controlling the morphogenesis of individual skeletal elements in the tetrapod limb. We now report the isolation of three new members of the transfo...

journal_title：Nature

authors： Storm EE,Huynh TV,Copeland NG,Jenkins NA,Kingsley DM,Lee SJ

更新日期：1994-04-14 00:00:00

abstract：:The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...

journal_title：Nature

authors： Peeper DS,Upton TM,Ladha MH,Neuman E,Zalvide J,Bernards R,DeCaprio JA,Ewen ME

更新日期：1997-03-13 00:00:00

abstract：:Bottom trawling is a non-selective commercial fishing technique whereby heavy nets and gear are pulled along the sea floor. The direct impact of this technique on fish populations and benthic communities has received much attention, but trawling can also modify the physical properties of seafloor sediments, water–sedi...

journal_title：Nature

authors： Puig P,Canals M,Company JB,Martín J,Amblas D,Lastras G,Palanques A

更新日期：2012-09-13 00:00:00

abstract：:The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although the importance of regions such as the ventral tegmental area3,4 and locus coeruleus5 in broa...

journal_title：Nature

authors： Chen S,He L,Huang AJY,Boehringer R,Robert V,Wintzer ME,Polygalov D,Weitemier AZ,Tao Y,Gu M,Middleton SJ,Namiki K,Hama H,Therreau L,Chevaleyre V,Hioki H,Miyawaki A,Piskorowski RA,McHugh TJ

更新日期：2020-10-01 00:00:00

abstract：:Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...

journal_title：Nature

authors： Huff V,Compton DA,Chao LY,Strong LC,Geiser CF,Saunders GF

更新日期：1988-11-24 00:00:00

abstract：:Cellular ras genes encode a family of membrane-associated proteins (p21ras) that bind guanine nucleotide and possess a low intrinsic GTPase activity. The p21ras proteins are ubiquitously expressed in mammalian cells and are thought to be involved in a growth-promoting signal transduction pathway; their mode of action,...

journal_title：Nature

authors： Graziadei L,Riabowol K,Bar-Sagi D

更新日期：1990-09-27 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24277. ...

journal_title：Nature

authors： GTEx Consortium.

更新日期：2018-01-25 00:00:00

abstract：:The AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun and c-Fos, controls the stimulation of cellular genes by growth factors and the expression of oncogenes, including src and ras. Transcriptional activation by c-Jun is regulated by a cell-type-specific inhibitor that represses th...

journal_title：Nature

authors： Baichwal VR,Park A,Tjian R

更新日期：1991-07-11 00:00:00

abstract：:Most of what is known about the evolution of deinonychosaurs (that is, the group of theropods most closely related to birds) is based on discoveries from North America and Asia. Except for Unenlagia comahuensis and some fragmentary remains from northern Africa, no other evidence was available on deinonychosaurian dive...

journal_title：Nature

authors： Novas FE,Pol D

更新日期：2005-02-24 00:00:00

abstract：:Circumstellar accretion disks transfer matter from molecular clouds to young stars and to the sites of planet formation. The disks observed around pre-main-sequence stars have properties consistent with those expected for the pre-solar nebula from which our own Solar System formed 4.5 Gyr ago. But the 'debris' disks t...

journal_title：Nature

authors： Thi WF,Blake GA,van Dishoeck EF,van Zadelhoff GJ,Horn JM,Becklin EE,Mannings V,Sargent AI,van Den Ancker ME,Natta A

更新日期：2001-01-04 00:00:00

abstract：:Heat is fundamental to power generation and many industrial processes, and is most useful at high temperatures because it can be converted more efficiently to other types of energy. However, efficient transportation, storage and conversion of heat at extreme temperatures (more than about 1,300 kelvin) is impractical f...

journal_title：Nature

authors： Amy C,Budenstein D,Bagepalli M,England D,DeAngelis F,Wilk G,Jarrett C,Kelsall C,Hirschey J,Wen H,Chavan A,Gilleland B,Yuan C,Chueh WC,Sandhage KH,Kawajiri Y,Henry A

更新日期：2017-10-11 00:00:00

abstract：:An important step towards understanding the molecular basis of the functional diversity of voltage-gated K+ channels in the mammalian brain has been the discovery of a family of genes encoding rat brain K+ channel-forming (RCK) proteins. All species of these RCK proteins form homomultimeric voltage-gated K+ channels w...

journal_title：Nature

authors： Ruppersberg JP,Schröter KH,Sakmann B,Stocker M,Sewing S,Pongs O

更新日期：1990-06-07 00:00:00

abstract：:The question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs suc...

journal_title：Nature

authors： Pontieri FE,Tanda G,Orzi F,Di Chiara G

更新日期：1996-07-18 00:00:00

abstract：:Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...

journal_title：Nature

authors： Toda S,Stein RS,Sagiya T

更新日期：2002-09-05 00:00:00

abstract：:Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among the most frequent events in human cancers1,2. However, pharmacol...

journal_title：Nature

authors： Hopkins BD,Pauli C,Du X,Wang DG,Li X,Wu D,Amadiume SC,Goncalves MD,Hodakoski C,Lundquist MR,Bareja R,Ma Y,Harris EM,Sboner A,Beltran H,Rubin MA,Mukherjee S,Cantley LC

更新日期：2018-08-01 00:00:00

abstract：:To understand the processes that regulate the abundance and persistence of wild populations is a fundamental goal of ecology and a prerequisite for the management of living resources. Variable abundance data, however, make the demonstration of regulation processes challenging. A previously overlooked aspect in underst...

journal_title：Nature

authors： Minto C,Myers RA,Blanchard W

更新日期：2008-03-20 00:00:00

abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

journal_title：Nature

authors： Bose HS,Lingappa VR,Miller WL

更新日期：2002-05-02 00:00:00

abstract：:Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans1,2 may contribute to this failure in translation. We tested three independent neuroprotective approache...

journal_title：Nature

authors： Esposito E,Li W,T Mandeville E,Park JH,Şencan I,Guo S,Shi J,Lan J,Lee J,Hayakawa K,Sakadžić S,Ji X,Lo EH

更新日期：2020-06-01 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:In vitro reconstitution of active ribulose bisphosphate carboxylase (Rubisco) from unfolded polypeptides is facilitated by the molecular chaperones: chaperonin-60 from Escherichia coli (groEL), yeast mitochondria (hsp60) or chloroplasts (Rubisco sub-unit-binding protein), together with chaperonin-10 from E. coli (groE...

journal_title：Nature

authors： Goloubinoff P,Christeller JT,Gatenby AA,Lorimer GH

更新日期：1989-12-21 00:00:00

abstract：:The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the intracellular effectors SMAD2 and SMAD3 (hereafter SMAD2/3), whose canonical function is to control the activity of target genes by interacting with transcriptiona...

journal_title：Nature

authors： Bertero A,Brown S,Madrigal P,Osnato A,Ortmann D,Yiangou L,Kadiwala J,Hubner NC,de Los Mozos IR,Sadée C,Lenaerts AS,Nakanoh S,Grandy R,Farnell E,Ule J,Stunnenberg HG,Mendjan S,Vallier L

更新日期：2018-03-08 00:00:00

abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

journal_title：Nature

authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

更新日期：1986-12-04 00:00:00

abstract：:Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...

journal_title：Nature

authors： Garris PA,Kilpatrick M,Bunin MA,Michael D,Walker QD,Wightman RM

更新日期：1999-03-04 00:00:00

abstract：:Successful expression of genes transferred into distantly related species in which genetic functions have been maintained through evolution has been reported previously. In the case of the silkmoth Bombyx mori and the fruitfly Drosophila melanogaster, both of which produce chorions (eggshells), Bombyx chorion genes ar...

journal_title：Nature

authors： Bello B,Couble P

更新日期：1990-08-02 00:00:00

abstract：:The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...

journal_title：Nature

authors： Dial OE,Ashoori RC,Pfeiffer LN,West KW

更新日期：2010-03-25 00:00:00

abstract：:The embryos and larvae of stalked crinoids, which are considered the most basal group of extant echinoderms, have not previously been described. In contrast, much is known about the development of the more accessible stalkless crinoids (feather stars), which are phylogenetically derived from stalked forms. Here we des...

journal_title：Nature

authors： Nakano H,Hibino T,Oji T,Hara Y,Amemiya S

更新日期：2003-01-09 00:00:00

abstract：:Meristems are distinctive regions of plants that have capacity for continuous growth. Their developmental activity generates the majority of plant organs. It is currently unknown how cell division and cell differentiation are orchestrated in meristems, although genetic studies have demonstrated the relevance of a prop...

journal_title：Nature

authors： van den Berg C,Willemsen V,Hendriks G,Weisbeek P,Scheres B

更新日期：1997-11-20 00:00:00

abstract：:Braunwald, a professor at Harvard Medical School, responds to a paper by Walter W. Stewart and Ned Feder ("The integrity of the scientific literature," Nature 1987 Jan 15; 325(6101): 207-214) concerning their findings of errors, discrepancies, and other lapses in publications coauthored by John Darsee, a biomedical re...

journal_title：Nature

authors： Braunwald E

更新日期：1987-01-15 00:00:00