Specific expression of a silk-encoding gene of Bombyx in the anterior salivary gland of Drosophila.

abstract：:(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin. Enzymes of this class typically catalyse oxygenation reactions that proceed via the formation of substrate radic...

journal_title：Nature

authors： Chang WC,Dey M,Liu P,Mansoorabadi SO,Moon SJ,Zhao ZK,Drennan CL,Liu HW

更新日期：2013-04-04 00:00:00

abstract：:Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...

journal_title：Nature

authors： Vita N,Platsaki S,Baslé A,Allen SJ,Paterson NG,Crombie AT,Murrell JC,Waldron KJ,Dennison C

更新日期：2015-09-03 00:00:00

abstract：: ...

journal_title：Nature

authors： Tall AR,Jelic S

更新日期：2019-02-01 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:Theory predicts that sexual behaviour in animals can evolve rapidly, accelerating the rate of species formation. Here we estimate the rate of speciation in Laupala, a group of forest-dwelling Hawaiian crickets that is characterized primarily through differences in male courtship song. We find that Laupala has the high...

journal_title：Nature

authors： Mendelson TC,Shaw KL

更新日期：2005-01-27 00:00:00

abstract：:A paramutation is an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification in the other allele without modifying the DNA sequence. The paramutated allele itself becomes paramutagenic, that is, capable of epigenetically converting a new paramutable allele. Here...

journal_title：Nature

authors： de Vanssay A,Bougé AL,Boivin A,Hermant C,Teysset L,Delmarre V,Antoniewski C,Ronsseray S

更新日期：2012-10-04 00:00:00

abstract：:Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering a...

journal_title：Nature

authors： Tanaka M,Sackmann E

更新日期：2005-09-29 00:00:00

abstract：:Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anth...

journal_title：Nature

authors： Ivanova N,Sorokin A,Anderson I,Galleron N,Candelon B,Kapatral V,Bhattacharyya A,Reznik G,Mikhailova N,Lapidus A,Chu L,Mazur M,Goltsman E,Larsen N,D'Souza M,Walunas T,Grechkin Y,Pusch G,Haselkorn R,Fonstein M,Ehrli

更新日期：2003-05-01 00:00:00

abstract：:During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps. With the exception of programmed stalling, which is usually used by cells for regulatory purposes, ribosomes stalled on mRNAs need to be terminated and recycled to m...

journal_title：Nature

authors： Ma C,Kurita D,Li N,Chen Y,Himeno H,Gao N

更新日期：2017-01-26 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:Haptic (touch) perception normally entails an active exploration of object surfaces over time. This is called active touch. When exploring the shape of an object, we experience both geometrical and force cues. For example, when sliding a finger across a surface with a rigid bump on it, the finger moves over the bump w...

journal_title：Nature

authors： Robles-De-La-Torre G,Hayward V

更新日期：2001-07-26 00:00:00

abstract：:All forms of locomotion are repetitive motor activities that require coordinated bilateral activation of muscles. The executive elements of locomotor control are networks of spinal neurons that determine gait pattern through the sequential activation of motor-neuron pools on either side of the body axis. However, litt...

journal_title：Nature

authors： Talpalar AE,Bouvier J,Borgius L,Fortin G,Pierani A,Kiehn O

更新日期：2013-08-01 00:00:00

abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...

journal_title：Nature

authors： Hannon JB,Hibino H,Bartelt NC,Swartzentruber BS,Ogino T,Kellogg GL

更新日期：2000-06-01 00:00:00

abstract：:Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells. This pivotal decision in a single gonadal cell type ultimately controls sexual differentiat...

journal_title：Nature

authors： Matson CK,Murphy MW,Sarver AL,Griswold MD,Bardwell VJ,Zarkower D

更新日期：2011-07-20 00:00:00

abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...

journal_title：Nature

authors： Mróz P,Udalski A,Skowron J,Poleski R,Kozłowski S,Szymański MK,Soszyński I,Wyrzykowski Ł,Pietrukowicz P,Ulaczyk K,Skowron D,Pawlak M

更新日期：2017-08-10 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the education of T cells in a specialized organ, the thymus, in which self-reactive cells are either eliminated or differentiated into tolerogenic Foxp3(+) regulatory T (T(reg)) cells. However, it is unknown...

journal_title：Nature

authors： Lathrop SK,Bloom SM,Rao SM,Nutsch K,Lio CW,Santacruz N,Peterson DA,Stappenbeck TS,Hsieh CS

更新日期：2011-09-21 00:00:00

abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...

journal_title：Nature

authors： Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,Meyerson M,Gabriel SB,Lander ES,Getz G

更新日期：2014-01-23 00:00:00

abstract：:Transparent electronic devices formed on flexible substrates are expected to meet emerging technological demands where silicon-based electronics cannot provide a solution. Examples of active flexible applications include paper displays and wearable computers. So far, mainly flexible devices based on hydrogenated amorp...

journal_title：Nature

authors： Nomura K,Ohta H,Takagi A,Kamiya T,Hirano M,Hosono H

更新日期：2004-11-25 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00

abstract：:Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...

journal_title：Nature

authors： Shorey L,Piertney S,Stone J,Höglund J

更新日期：2000-11-16 00:00:00

abstract：:The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates bo...

journal_title：Nature

authors： Hayashi M,Nakashima T,Taniguchi M,Kodama T,Kumanogoh A,Takayanagi H

更新日期：2012-05-03 00:00:00

abstract：:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...

journal_title：Nature

authors： Wellenstein MD,Coffelt SB,Duits DEM,van Miltenburg MH,Slagter M,de Rink I,Henneman L,Kas SM,Prekovic S,Hau CS,Vrijland K,Drenth AP,de Korte-Grimmerink R,Schut E,van der Heijden I,Zwart W,Wessels LFA,Schumacher TN,Jonk

更新日期：2019-08-01 00:00:00

abstract：:The formation of condensed (compacted) protein phases is associated with a wide range of human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia and Alzheimer's disease. However, condensed protein phases have their uses: as crystals, they are harnessed by structural biologists to elu...

journal_title：Nature

authors： Van Driessche AES,Van Gerven N,Bomans PHH,Joosten RRM,Friedrich H,Gil-Carton D,Sommerdijk NAJM,Sleutel M

更新日期：2018-04-04 00:00:00

abstract：:Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions...

journal_title：Nature

authors： Zou Y,Henry WS,Ricq EL,Graham ET,Phadnis VV,Maretich P,Paradkar S,Boehnke N,Deik AA,Reinhardt F,Eaton JK,Ferguson B,Wang W,Fairman J,Keys HR,Dančík V,Clish CB,Clemons PA,Hammond PT,Boyer LA,Weinberg RA,Schreiber

更新日期：2020-09-01 00:00:00

abstract：:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...

journal_title：Nature

authors： Slot JW,Moxley R,Geuze HJ,James DE

更新日期：1990-07-26 00:00:00

abstract：:Binocular coordination of eye movements is essential for stereopsis (depth perception) and to prevent double vision. More than a century ago, Hering and Helmholtz debated the neural basis of binocular coordination. Helmholtz believed that each eye is controlled independently and that binocular coordination is learned....

journal_title：Nature

authors： Zhou W,King WM

更新日期：1998-06-18 00:00:00

abstract：:Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the associat...

journal_title：Nature

authors： Lu H,Zawel L,Fisher L,Egly JM,Reinberg D

更新日期：1992-08-20 00:00:00

abstract：:Speciation in many animal taxa is catalysed by the evolutionary diversification of mating signals. According to classical theories of speciation, mating signals diversify, in part, as an incidental byproduct of adaptation by natural selection to divergent ecologies, although empirical evidence in support of this hypot...

journal_title：Nature

authors： Podos J

更新日期：2001-01-11 00:00:00

abstract：:Haemophilia B (Christmas disease) is an inherited, recessive, sex-linked, haemorrhagic condition caused by a defect in the intrinsic clotting factor IX. This disease occurs in males at a frequency of approximately 1 in 30,000. Patients differ in the severity of their clinical symptoms, and variation in the clotting ac...

journal_title：Nature

authors： Rees DJ,Rizza CR,Brownlee GG

更新日期：1985-08-15 00:00:00