Abstract:
:A paramutation is an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification in the other allele without modifying the DNA sequence. The paramutated allele itself becomes paramutagenic, that is, capable of epigenetically converting a new paramutable allele. Here we describe a case of paramutation in animals showing long-term transmission over generations. We previously characterized a homology-dependent silencing mechanism referred to as the trans-silencing effect (TSE), involved in P-transposable-element repression in the germ line. We now show that clusters of P-element-derived transgenes that induce strong TSE can convert other homologous transgene clusters incapable of TSE into strong silencers, which transmit the acquired silencing capacity through 50 generations. The paramutation occurs without any need for chromosome pairing between the paramutagenic and the paramutated loci, and is mediated by maternal inheritance of cytoplasm carrying Piwi-interacting RNAs (piRNAs) homologous to the transgenes. The repression capacity of the paramutated locus is abolished by a loss-of-function mutation of the aubergine gene involved in piRNA biogenesis, but not by a loss-of-function mutation of the Dicer-2 gene involved in siRNA production. The paramutated cluster, previously producing barely detectable levels of piRNAs, is converted into a stable, strong piRNA-producing locus by the paramutation and becomes fully paramutagenic itself. Our work provides a genetic model for the emergence of piRNA loci, as well as for RNA-mediated trans-generational repression of transposable elements.
journal_name
Naturejournal_title
Natureauthors
de Vanssay A,Bougé AL,Boivin A,Hermant C,Teysset L,Delmarre V,Antoniewski C,Ronsseray Sdoi
10.1038/nature11416subject
Has Abstractpub_date
2012-10-04 00:00:00pages
112-5issue
7418eissn
0028-0836issn
1476-4687pii
nature11416journal_volume
490pub_type
杂志文章相关文献
NATURE文献大全abstract::Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19328
更新日期:2016-09-01 00:00:00
abstract::The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04844
更新日期:2006-06-22 00:00:00
abstract::C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360127a0
更新日期:1992-11-12 00:00:00
abstract::Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09571
更新日期:2010-12-02 00:00:00
abstract::Rapidly advancing knowledge of genome structure and sequence enables new means for the analysis of specific DNA changes associated with the differences between the human brain and that of other mammals. Recent studies implicate evolutionary changes in messenger RNA and protein expression levels, as well as DNA changes...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04103
更新日期:2005-09-01 00:00:00
abstract::Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03937
更新日期:2005-07-14 00:00:00
abstract::The distribution, accumulation and circulation of oxygen and hydrogen in Earth's interior dictate the geochemical evolution of the hydrosphere, atmosphere and biosphere. The oxygen-rich atmosphere and iron-rich core represent two end-members of the oxygen-iron (O-Fe) system, overlapping with the entire pressure-temper...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature18018
更新日期:2016-06-09 00:00:00
abstract::Plate tectonics successfully describes the surface of Earth as a mosaic of moving lithospheric plates. But it is not clear what happens at the base of the plates, the lithosphere-asthenosphere boundary (LAB). The LAB has been well imaged with converted teleseismic waves, whose 10-40-kilometre wavelength controls the s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14146
更新日期:2015-02-05 00:00:00
abstract::In 1975-79, joint expeditions from Yale University and the Geological Survey of Pakistan (YGSP) recovered fossil lorisids in the Siwalik Group of Pakistan from four localities, spanning a period before 10 Myr ago to about 7 Myr ago. In three of the localities, only isolated teeth or fragments were found, whereas the f...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/289585a0
更新日期:1981-02-12 00:00:00
abstract::The increasing ability to control light-matter interactions at the nanometre scale has improved the performance of semiconductor lasers in the past decade. The ultimate optimization is realized in semiconductor microcavities, in which strong coupling between quantum-well excitons and cavity photons gives rise to hybri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06979
更新日期:2008-05-15 00:00:00
abstract::Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24037
更新日期:2017-10-12 00:00:00
abstract::Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06609
更新日期:2008-02-21 00:00:00
abstract::During serial structure analysis of cobaloxime derivatives, aimed at interpreting the catalytic capability of the asymmetric hydrogenation, we have found that the crystal of R-alpha-cyanoethyl (S-alpha-methylbenzylamine)-cobaloxime changes its unit cell dimensions by X-ray exposure without degradation of a single crys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/267142a0
更新日期:1977-05-12 00:00:00
abstract::Seismological studies have revealed that a complex texture or heterogeneity exists in the Earth's inner core and at the boundary between core and mantle. These studies highlight the importance of understanding the properties of iron when modelling the composition and dynamics of the core and the interaction of the cor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35087559
更新日期:2001-08-02 00:00:00
abstract::Transition-metal perovskite oxides exhibit a wide range of extraordinary but imperfectly understood phenomena. The best known examples are high-temperature superconductivity in copper oxides, and colossal magnetoresistance in manganese oxides ('manganites'). All of these materials undergo a range of order-disorder tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416518a
更新日期:2002-04-04 00:00:00
abstract::Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387422a0
更新日期:1997-05-22 00:00:00
abstract::Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1155-x
更新日期:2019-05-01 00:00:00
abstract::The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper fun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01543
更新日期:2003-05-01 00:00:00
abstract::Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular-matrix ligands, transmitting forces and signals necessary for locomotion. Whether cells will migrate or not on a given substratum, and also their speed, depends on several variables related ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/385537a0
更新日期:1997-02-06 00:00:00
abstract::Single-stranded DNA can fold into well-defined sequence-dependent tertiary structures that specifically bind a variety of target molecules, raising the possibility that some folded single-stranded DNAs might exhibit catalytic activities similar to those of ribozymes and protein enzymes. Derivatives of the hammerhead r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375611a0
更新日期:1995-06-15 00:00:00
abstract::Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03391
更新日期:2005-03-10 00:00:00
abstract::It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature18846
更新日期:2016-07-07 00:00:00
abstract::The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the education of T cells in a specialized organ, the thymus, in which self-reactive cells are either eliminated or differentiated into tolerogenic Foxp3(+) regulatory T (T(reg)) cells. However, it is unknown...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10434
更新日期:2011-09-21 00:00:00
abstract::Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11147
更新日期:2012-06-28 00:00:00
abstract::Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the develope...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06797
更新日期:2008-02-21 00:00:00
abstract::Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/374546a0
更新日期:1995-04-06 00:00:00
abstract::Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04542
更新日期:2006-03-16 00:00:00
abstract::Long-term reconstitution of the lymphohaematopoietic cells of a mouse after lethal irradiation requires the transplantation of at least (5-10) x 10(3) bone marrow cells. Several cell-separation techniques based on cell-surface characteristics have been used in attempts to identify the pluripotent haematopoietic stem c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347188a0
更新日期:1990-09-13 00:00:00
abstract::Microscopic diamond was recently discovered in oxidized acid residues from several carbonaceous chondrite meteorites (for example, the C delta component of the Allende meteorite). Some of the reported properties of C delta seem in conflict with those expected of diamond. Here we present high spatial resolution analy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332611a0
更新日期:1988-04-14 00:00:00
abstract::Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338651a0
更新日期:1989-04-20 00:00:00