Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells.

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...

journal_title：Nature

authors： Seeholzer LF,Seppo M,Stern DL,Ruta V

更新日期：2018-07-01 00:00:00

abstract：:Knowledge of the contribution that individual countries have made to global radiative forcing is important to the implementation of the agreement on "common but differentiated responsibilities" reached by the United Nations Framework Convention on Climate Change. Over the past three decades, China has experienced rapi...

journal_title：Nature

authors： Li B,Gasser T,Ciais P,Piao S,Tao S,Balkanski Y,Hauglustaine D,Boisier JP,Chen Z,Huang M,Li LZ,Li Y,Liu H,Liu J,Peng S,Shen Z,Sun Z,Wang R,Wang T,Yin G,Yin Y,Zeng H,Zeng Z,Zhou F

更新日期：2016-03-17 00:00:00

abstract：:A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal s...

journal_title：Nature

authors： Saper CB,Scammell TE,Lu J

更新日期：2005-10-27 00:00:00

abstract：:Many natural products that contain basic nitrogen atoms--for example alkaloids like morphine and quinine-have the potential to treat a broad range of human diseases. However, the presence of a nitrogen atom in a target molecule can complicate its chemical synthesis because of the basicity of nitrogen atoms and their s...

journal_title：Nature

authors： Mercado-Marin EV,Garcia-Reynaga P,Romminger S,Pimenta EF,Romney DK,Lodewyk MW,Williams DE,Andersen RJ,Miller SJ,Tantillo DJ,Berlinck RGS,Sarpong R

更新日期：2014-05-15 00:00:00

abstract：:Macroscopic mechanical objects and electromagnetic degrees of freedom can couple to each other through radiation pressure. Optomechanical systems in which this coupling is sufficiently strong are predicted to show quantum effects and are a topic of considerable interest. Devices in this regime would offer new types of...

journal_title：Nature

authors： Thompson JD,Zwickl BM,Jayich AM,Marquardt F,Girvin SM,Harris JG

更新日期：2008-03-06 00:00:00

abstract：:The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...

journal_title：Nature

authors： Ruan Z,Osei-Owusu J,Du J,Qiu Z,Lü W

更新日期：2020-12-01 00:00:00

abstract：:The medial entorhinal cortex (MEC) is part of the brain's circuit for dynamic representation of self-location. The metric of this representation is provided by grid cells, cells with spatial firing fields that tile environments in a periodic hexagonal pattern. Limited anatomical sampling has obscured whether the grid ...

journal_title：Nature

authors： Stensola H,Stensola T,Solstad T,Frøland K,Moser MB,Moser EI

更新日期：2012-12-06 00:00:00

abstract：:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest tha...

journal_title：Nature

authors： Canter RG,Penney J,Tsai LH

更新日期：2016-11-10 00:00:00

abstract：:Deep neural networks have achieved impressive successes in fields ranging from object recognition to complex games such as Go1,2. Navigation, however, remains a substantial challenge for artificial agents, with deep neural networks trained by reinforcement learning3-5 failing to rival the proficiency of mammalian spat...

journal_title：Nature

authors： Banino A,Barry C,Uria B,Blundell C,Lillicrap T,Mirowski P,Pritzel A,Chadwick MJ,Degris T,Modayil J,Wayne G,Soyer H,Viola F,Zhang B,Goroshin R,Rabinowitz N,Pascanu R,Beattie C,Petersen S,Sadik A,Gaffney S,King H

更新日期：2018-05-01 00:00:00

abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...

journal_title：Nature

authors： Kang Y,Kuybeda O,de Waal PW,Mukherjee S,Van Eps N,Dutka P,Zhou XE,Bartesaghi A,Erramilli S,Morizumi T,Gu X,Yin Y,Liu P,Jiang Y,Meng X,Zhao G,Melcher K,Ernst OP,Kossiakoff AA,Subramaniam S,Xu HE

更新日期：2018-06-01 00:00:00

abstract：:Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at ...

journal_title：Nature

authors： Wu X,Northcott PA,Dubuc A,Dupuy AJ,Shih DJ,Witt H,Croul S,Bouffet E,Fults DW,Eberhart CG,Garzia L,Van Meter T,Zagzag D,Jabado N,Schwartzentruber J,Majewski J,Scheetz TE,Pfister SM,Korshunov A,Li XN,Scherer SW,Ch

更新日期：2012-02-15 00:00:00

abstract：:Three Hipparion trails, two from adults and one from a juvenile dating from about 3.5 Myr ago, have now been found in Laetoli. Comparison of the Hipparion footprints with a variety of imprints made by domestic horses showed that the animals moved with a running walk over the soft and slippery soil of Laetoli: in the a...

journal_title：Nature

authors： Renders E

更新日期：1984-03-08 00:00:00

abstract：:Measurement of the free calcium concentration within a photo-receptor outer segment has been considered an important aim since the proposal by Hagins and Yoshikami that the primary event in phototransduction is a release of Ca (2+) inside the cell. More recent evidence has cast doubt on the calcium hypothesis, and the...

journal_title：Nature

authors： McNaughton PA,Cervetto L,Nunn BJ

更新日期：1986-07-17 00:00:00

abstract：:The guanine nucleotide-binding stimulatory protein (Gs) couples hormone-receptor interaction to the activation of adenylate cyclase and the generation of cyclic AMP. Studies using frog neuroepithelium indicate that the sense of smell is mediated by a Gs-adenylate cyclase system, and this prompted us to test olfaction ...

journal_title：Nature

authors： Weinstock RS,Wright HN,Spiegel AM,Levine MA,Moses AM

更新日期：1986-08-14 00:00:00

abstract：:The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...

journal_title：Nature

authors： Nijhawan R

更新日期：1997-03-06 00:00:00

abstract：:Quantum teleportation allows for the transfer of arbitrary unknown quantum states from a sender to a spatially distant receiver, provided that the two parties share an entangled state and can communicate classically. It is the essence of many sophisticated protocols for quantum communication and computation. Photons a...

journal_title：Nature

authors： Takeda S,Mizuta T,Fuwa M,van Loock P,Furusawa A

更新日期：2013-08-15 00:00:00

abstract：:The potential use of smallpox as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers. Another public health goal is the licensing of a safer vaccine that could benefit the millions of people advised not to take the current one because they o...

journal_title：Nature

authors： Earl PL,Americo JL,Wyatt LS,Eller LA,Whitbeck JC,Cohen GH,Eisenberg RJ,Hartmann CJ,Jackson DL,Kulesh DA,Martinez MJ,Miller DM,Mucker EM,Shamblin JD,Zwiers SH,Huggins JW,Jahrling PB,Moss B

更新日期：2004-03-11 00:00:00

abstract：:Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...

journal_title：Nature

authors： Grivennikov SI,Wang K,Mucida D,Stewart CA,Schnabl B,Jauch D,Taniguchi K,Yu GY,Osterreicher CH,Hung KE,Datz C,Feng Y,Fearon ER,Oukka M,Tessarollo L,Coppola V,Yarovinsky F,Cheroutre H,Eckmann L,Trinchieri G,Karin M

更新日期：2012-11-08 00:00:00

abstract：:Most of the progress in human culture has required the exploitation of energy resources. About 100 years ago, the major source of energy shifted from recent solar to fossil hydrocarbons, including liquid and gaseous petroleum. Technology has generally led to a greater use of hydrocarbon fuels for most human activities...

journal_title：Nature

authors： Hall C,Tharakan P,Hallock J,Cleveland C,Jefferson M

更新日期：2003-11-20 00:00:00

abstract：:The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...

journal_title：Nature

authors： Janvier P

更新日期：2015-04-23 00:00:00

abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

journal_title：Nature

authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

更新日期：1995-10-12 00:00:00

abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...

journal_title：Nature

authors： Krot AN,Yurimoto H,Hutcheon ID,MacPherson GJ

更新日期：2005-04-21 00:00:00

abstract：:Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist ...

journal_title：Nature

authors： Beura LK,Hamilton SE,Bi K,Schenkel JM,Odumade OA,Casey KA,Thompson EA,Fraser KA,Rosato PC,Filali-Mouhim A,Sekaly RP,Jenkins MK,Vezys V,Haining WN,Jameson SC,Masopust D

更新日期：2016-04-28 00:00:00

abstract：:p97 is a 97,000 molecular weight cell-surface glycoprotein, which is present in human melanomas but in only trace amounts in normal adult tissues. Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin. Reports that the genes for the transferrin recepto...

journal_title：Nature

authors： Plowman GD,Brown JP,Enns CA,Schröder J,Nikinmaa B,Sussman HH,Hellström KE,Hellström I

更新日期：1983-05-05 00:00:00

abstract：:Thomas et al. argue, contrary to Sala et al. that climate change poses an equal or greater threat to global biodiversity than land-use change. We contest this claim, however, on the grounds that Thomas et al. incorrectly apply species-area relationships. ...

journal_title：Nature

authors： Buckley LB,Roughgarden J

更新日期：2004-07-01 00:00:00

abstract：:The biosynthesis of several protein cofactors is subject to feedback regulation by riboswitches. Flavin mononucleotide (FMN)-specific riboswitches, also known as RFN elements, direct expression of bacterial genes involved in the biosynthesis and transport of riboflavin (vitamin B(2)) and related compounds. Here we pre...

journal_title：Nature

authors： Serganov A,Huang L,Patel DJ

更新日期：2009-03-12 00:00:00

abstract：:Aerobic methanotrophic bacteria consume methane as it diffuses away from methanogenic zones of soil and sediment. They act as a biofilter to reduce methane emissions to the atmosphere, and they are therefore targets in strategies to combat global climate change. No cultured methanotroph grows optimally below pH 5, but...

journal_title：Nature

authors： Dunfield PF,Yuryev A,Senin P,Smirnova AV,Stott MB,Hou S,Ly B,Saw JH,Zhou Z,Ren Y,Wang J,Mountain BW,Crowe MA,Weatherby TM,Bodelier PL,Liesack W,Feng L,Wang L,Alam M

更新日期：2007-12-06 00:00:00

abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...

journal_title：Nature

authors： Fischer KD,Zmuldzinas A,Gardner S,Barbacid M,Bernstein A,Guidos C

更新日期：1995-03-30 00:00:00

abstract：:RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...

journal_title：Nature

authors： Dock-Bregeon AC,Chevrier B,Podjarny A,Moras D,deBear JS,Gough GR,Gilham PT,Johnson JE

更新日期：1988-09-22 00:00:00