Molecular insights into human brain evolution.

abstract：:Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...

journal_title：Nature

authors： Seeholzer LF,Seppo M,Stern DL,Ruta V

更新日期：2018-07-01 00:00:00

abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

journal_title：Nature

authors： Bose HS,Lingappa VR,Miller WL

更新日期：2002-05-02 00:00:00

abstract：:Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...

journal_title：Nature

authors： Zhang Z,Zhang Y,Xia S,Kong Q,Li S,Liu X,Junqueira C,Meza-Sosa KF,Mok TMY,Ansara J,Sengupta S,Yao Y,Wu H,Lieberman J

更新日期：2020-03-01 00:00:00

abstract：:Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The ...

journal_title：Nature

authors： Gething MJ,Bye J,Skehel J,Waterfield M

更新日期：1980-09-25 00:00:00

abstract：:The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis an...

journal_title：Nature

authors： Herndon LA,Schmeissner PJ,Dudaronek JM,Brown PA,Listner KM,Sakano Y,Paupard MC,Hall DH,Driscoll M

更新日期：2002-10-24 00:00:00

abstract：:A major goal of molecular oncology is to identify means to kill cells lacking p53 function. Most current cancer therapy is based on damaging cellular DNA by irradiation or chemicals. Recent reports support the notion that, in the event of DNA damage, the p53 tumour-suppressor protein is able to prevent cell death by s...

journal_title：Nature

authors： Raj K,Ogston P,Beard P

更新日期：2001-08-30 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2019-01-01 00:00:00

abstract：:For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...

journal_title：Nature

authors： Fenton LK,Geissler PE,Haberle RM

更新日期：2007-04-05 00:00:00

abstract：:The formation of disulphide bonds is essential to the structure and function of proteins. These bonds rapidly form either cotranslationally or immediately post-translationally in the lumen of the endoplasmic reticulum. Native disulphide pairing for such proteins has been achieved in vitro; however, the rates of reasse...

journal_title：Nature

authors： Edman JC,Ellis L,Blacher RW,Roth RA,Rutter WJ

更新日期：1985-09-19 00:00:00

abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...

journal_title：Nature

authors： Cook DL,Hales CN

更新日期：1984-09-20 00:00:00

abstract：:Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...

journal_title：Nature

authors： Woychik RP,Maas RL,Zeller R,Vogt TF,Leder P

更新日期：1990-08-30 00:00:00

abstract：:Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...

journal_title：Nature

authors： Fawzi NL,Ying J,Ghirlando R,Torchia DA,Clore GM

更新日期：2011-10-30 00:00:00

abstract：:The requirement of metabolic energy for the interaction of polyene macrolide antibiotics with eukaryotic organisms remains a controversial subject (for review see ref. 1) It has been claimed that the lethal binding of these antibiotics to the sterol target component of the hydrophobic core of the membrane, in accordan...

journal_title：Nature

authors： Malewicz B,Borowski E

更新日期：1979-09-06 00:00:00

abstract：:During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are cr...

journal_title：Nature

authors： Zeng W,Wharton KA Jr,Mack JA,Wang K,Gadbaw M,Suyama K,Klein PS,Scott MP

更新日期：2000-02-17 00:00:00

abstract：:Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...

journal_title：Nature

authors： Bullitt E,Makowski L

更新日期：1995-01-12 00:00:00

abstract：:In many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools. Most investigations have characterized Ca2+ influx indirectly by measuring Ca(2+)-activa...

journal_title：Nature

authors： Hoth M,Penner R

更新日期：1992-01-23 00:00:00

abstract：:A review of fossil mammalian faunas from the Middle Awash indicates they span most of the later Neogene and document evolutionary change in several mammalian groups, especially Primates, Proboscidea and Artiodactyla. Oldowan artefacts first appear in the late Pliocene, while Acheulian and later industries and apparent...

journal_title：Nature

authors： Kalb JE,Jolly CJ,Mebrate A,Tebedge S,Smart C,Oswald EB,Cramer D,Whitehead P,Wood CB,Conroy GC,Adefris T,Sperling L,Kana B

更新日期：1982-07-01 00:00:00

abstract：:A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...

journal_title：Nature

authors： Engel MH,Macko SA,Silfer JA

更新日期：1990-11-01 00:00:00

abstract：:A plasmalemmal Na(+)-Ca2+ exchange mechanism is an important electrogenic determinant of contractility in cardiac cells. As in other cell types, calcium influx by Na(+)-Ca2+ exchange is secondarily activated by cytoplasmic calcium and probably ATP, but these modulatory mechanisms are either absent or altered in isolat...

journal_title：Nature

authors： Hilgemann DW

更新日期：1990-03-15 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Ka...

journal_title：Nature

authors： Bais C,Santomasso B,Coso O,Arvanitakis L,Raaka EG,Gutkind JS,Asch AS,Cesarman E,Gershengorn MC,Mesri EA

更新日期：1998-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24295. ...

journal_title：Nature

authors： Waldron A,Miller DC,Redding D,Mooers A,Kuhn TS,Nibbelink N,Roberts JT,Tobias JA,Gittleman JL

更新日期：2018-01-25 00:00:00

abstract：:Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...

journal_title：Nature

authors： Seo MD,Velamakanni S,Ishiyama N,Stathopulos PB,Rossi AM,Khan SA,Dale P,Li C,Ames JB,Ikura M,Taylor CW

更新日期：2012-01-29 00:00:00

abstract：:Anti-cancer agents that have been made selective for tumour cells by exploiting the known differences in the availability of oxygen between normal and transformed cells are a promising development in cancer chemotherapy. We have recently suggested a new type of bioreductive activity which would depend on a two-electro...

journal_title：Nature

authors： Reynolds CA,King PM,Richards WG

更新日期：1988-07-07 00:00:00

abstract：:Group selection may be defined as selection caused by the differential extinction or proliferation of groups. The socially polymorphic spider Anelosimus studiosus exhibits a behavioural polymorphism in which females exhibit either a 'docile' or 'aggressive' behavioural phenotype. Natural colonies are composed of a mix...

journal_title：Nature

authors： Pruitt JN,Goodnight CJ

更新日期：2014-10-16 00:00:00

abstract：:Molecular self-assembly offers a 'bottom-up' route to fabrication with subnanometre precision of complex structures from simple components. DNA has proved to be a versatile building block for programmable construction of such objects, including two-dimensional crystals, nanotubes, and three-dimensional wireframe nanop...

journal_title：Nature

authors： Douglas SM,Dietz H,Liedl T,Högberg B,Graf F,Shih WM

更新日期：2009-05-21 00:00:00

abstract：:To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...

journal_title：Nature

authors： Lanzavecchia A,Roosnek E,Gregory T,Berman P,Abrignani S

更新日期：1988-08-11 00:00:00

abstract：: ...

journal_title：Nature

authors： Butchart SHM,Clements A,Gibbons DW

更新日期：2019-02-01 00:00:00

abstract：:Recurring outbursts associated with matter flowing onto compact stellar remnants (such as black holes, neutron stars and white dwarfs) in close binary systems provide a way of constraining the poorly understood accretion process. The light curves of these outbursts are shaped by the efficiency of angular-momentum (and...

journal_title：Nature

authors： Tetarenko BE,Lasota JP,Heinke CO,Dubus G,Sivakoff GR

更新日期：2018-02-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Smallman M

更新日期：2019-03-01 00:00:00

abstract：:Phytoplankton size structure is acknowledged as a fundamental property determining energy flow through 'microbial' or 'herbivore' pathways. The balance between these two pathways determines the ability of the ecosystem to recycle carbon within the upper layer or to export it to the ocean interior. Small cells are usua...

journal_title：Nature

authors： Rodríguez J,Tintoré J,Allen JT,Blanco JM,Gomis D,Reul A,Ruiz J,Rodríguez V,Echevarría F,Jiménez-Gómez F

更新日期：2001-03-15 00:00:00