Abstract:
:Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs.
journal_name
Naturejournal_title
Natureauthors
Mackman Ndoi
10.1038/nature06797subject
Has Abstractpub_date
2008-02-21 00:00:00pages
914-8issue
7181eissn
0028-0836issn
1476-4687pii
nature06797journal_volume
451pub_type
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