Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

abstract：:Nuclear exclusion of the PTEN (phosphatase and tensin homologue deleted in chromosome 10) tumour suppressor has been associated with cancer progression. However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN a...

journal_title：Nature

authors： Song MS,Salmena L,Carracedo A,Egia A,Lo-Coco F,Teruya-Feldstein J,Pandolfi PP

更新日期：2008-10-09 00:00:00

abstract：:Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...

journal_title：Nature

authors： Koning AA,Perales KM,Fluet-Chouinard E,McIntyre PB

更新日期：2020-12-01 00:00:00

abstract：:Globular star clusters that formed at the same cosmic time may have evolved rather differently from the dynamical point of view (because that evolution depends on the internal environment) through a variety of processes that tend progressively to segregate stars more massive than the average towards the cluster centre...

journal_title：Nature

authors： Ferraro FR,Lanzoni B,Dalessandro E,Beccari G,Pasquato M,Miocchi P,Rood RT,Sigurdsson S,Sills A,Vesperini E,Mapelli M,Contreras R,Sanna N,Mucciarelli A

更新日期：2012-12-20 00:00:00

abstract：:Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...

journal_title：Nature

authors： Pepys MB,Hirschfield GM,Tennent GA,Gallimore JR,Kahan MC,Bellotti V,Hawkins PN,Myers RM,Smith MD,Polara A,Cobb AJ,Ley SV,Aquilina JA,Robinson CV,Sharif I,Gray GA,Sabin CA,Jenvey MC,Kolstoe SE,Thompson D,Wood SP

更新日期：2006-04-27 00:00:00

abstract：:The detection of electron spins associated with single defects in solids is a critical operation for a range of quantum information and measurement applications under development. So far, it has been accomplished for only two defect centres in crystalline solids: phosphorus dopants in silicon, for which electrical rea...

journal_title：Nature

authors： Yin C,Rancic M,de Boo GG,Stavrias N,McCallum JC,Sellars MJ,Rogge S

更新日期：2013-05-02 00:00:00

abstract：:The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...

journal_title：Nature

authors： Havran WL,Allison JP

更新日期：1990-03-01 00:00:00

abstract：:Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of START proteins, but it remains unclear how these receptors bind ABA and, in turn, how hormone binding leads to inhibition of the downstream ...

journal_title：Nature

authors： Melcher K,Ng LM,Zhou XE,Soon FF,Xu Y,Suino-Powell KM,Park SY,Weiner JJ,Fujii H,Chinnusamy V,Kovach A,Li J,Wang Y,Li J,Peterson FC,Jensen DR,Yong EL,Volkman BF,Cutler SR,Zhu JK,Xu HE

更新日期：2009-12-03 00:00:00

abstract：:Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...

journal_title：Nature

authors： Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

更新日期：2018-12-01 00:00:00

abstract：:Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental signalling steps in the central nervous system. It is generally assumed that fast transmitter release is triggered by elevations in intracellular calcium concentration ([Ca2+]i) to at least 100 microM near the sites of vesicle f...

journal_title：Nature

authors： Schneggenburger R,Neher E

更新日期：2000-08-24 00:00:00

abstract：:It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...

journal_title：Nature

authors： Folkard S,Hume KI,Minors DS,Waterhouse JM,Watson FL

更新日期：1985-02-21 00:00:00

abstract：:The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents...

journal_title：Nature

authors： Mnih V,Kavukcuoglu K,Silver D,Rusu AA,Veness J,Bellemare MG,Graves A,Riedmiller M,Fidjeland AK,Ostrovski G,Petersen S,Beattie C,Sadik A,Antonoglou I,King H,Kumaran D,Wierstra D,Legg S,Hassabis D

更新日期：2015-02-26 00:00:00

abstract：:The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...

journal_title：Nature

authors： Graham DW,Blichert-Toft J,Russo CJ,Rubin KH,Albarède F

更新日期：2006-03-09 00:00:00

abstract：:The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing m...

journal_title：Nature

authors： Bourdeau RW,Lee-Gosselin A,Lakshmanan A,Farhadi A,Kumar SR,Nety SP,Shapiro MG

更新日期：2018-01-03 00:00:00

abstract：:Plant respiration results in an annual flux of carbon dioxide (CO2) to the atmosphere that is six times as large as that due to the emissions from fossil fuel burning, so changes in either will impact future climate. As plant respiration responds positively to temperature, a warming world may result in additional resp...

journal_title：Nature

authors： Reich PB,Sendall KM,Stefanski A,Wei X,Rich RL,Montgomery RA

更新日期：2016-03-31 00:00:00

abstract：:Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoprotein...

journal_title：Nature

authors： Ou WJ,Cameron PH,Thomas DY,Bergeron JJ

更新日期：1993-08-26 00:00:00

abstract：:Multicomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular...

journal_title：Nature

authors： Zhang X,Smith RT,Le C,McCarver SJ,Shireman BT,Carruthers NI,MacMillan DWC

更新日期：2020-04-01 00:00:00

abstract：:Hypogonadism in the mutant hpg mouse is characterized by a deficiency of hypothalamic gonadotropin releasing hormone (GnRH). Affected male mice exhibit immature reproductive organs, small abdominal testes and low pituitary and plasma gonadotropin concentrations. Recent studies have demonstrated the potential of fetal ...

journal_title：Nature

authors： Krieger DT,Perlow MJ,Gibson MJ,Davies TF,Zimmerman EA,Ferin M,Charlton HM

更新日期：1982-07-29 00:00:00

abstract：:The recognition and localization of sound signals is fundamental to acoustic communication. Complex neural mechanisms are thought to underlie the processing of species-specific sound patterns even in animals with simple auditory pathways. In female crickets, which orient towards the male's calling song, current models...

journal_title：Nature

authors： Hedwig B,Poulet JF

更新日期：2004-08-12 00:00:00

abstract：:The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smok...

journal_title：Nature

authors： Fowler JS,Volkow ND,Wang GJ,Pappas N,Logan J,MacGregor R,Alexoff D,Shea C,Schlyer D,Wolf AP,Warner D,Zezulkova I,Cilento R

更新日期：1996-02-22 00:00:00

abstract：:Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...

journal_title：Nature

authors： Shackleton N,Renfrew C

更新日期：1970-12-12 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify,...

journal_title：Nature

authors： Froguel P,Vaxillaire M,Sun F,Velho G,Zouali H,Butel MO,Lesage S,Vionnet N,Clément K,Fougerousse F

更新日期：1992-03-12 00:00:00

abstract：:Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbach...

journal_title：Nature

authors： Hoffmann AA,Montgomery BL,Popovici J,Iturbe-Ormaetxe I,Johnson PH,Muzzi F,Greenfield M,Durkan M,Leong YS,Dong Y,Cook H,Axford J,Callahan AG,Kenny N,Omodei C,McGraw EA,Ryan PA,Ritchie SA,Turelli M,O'Neill SL

更新日期：2011-08-24 00:00:00

abstract：:Thermodynamics predicts that transmembrane voltage modulates membrane tension and that this will cause movement. The magnitude and polarity of movement is governed by cell stiffness and surface potentials. Here we confirm these predictions using the atomic force microscope to dynamically follow the movement of voltage...

journal_title：Nature

authors： Zhang PC,Keleshian AM,Sachs F

更新日期：2001-09-27 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:The violation of a Bell inequality is an experimental observation that forces the abandonment of a local realistic viewpoint--namely, one in which physical properties are (probabilistically) defined before and independently of measurement, and in which no physical influence can propagate faster than the speed of light...

journal_title：Nature

authors： Giustina M,Mech A,Ramelow S,Wittmann B,Kofler J,Beyer J,Lita A,Calkins B,Gerrits T,Nam SW,Ursin R,Zeilinger A

更新日期：2013-05-09 00:00:00

abstract：:In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

journal_title：Nature

authors： Payre F,Vincent A,Carreno S

更新日期：1999-07-15 00:00:00

abstract：:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...

journal_title：Nature

authors： Lee KY,Peters MC,Anderson KW,Mooney DJ

更新日期：2000-12-21 00:00:00

abstract：:In the few species of birds in which males form display partnerships to attract females, one male secures most or all of the copulations. This leads to the question of why subordinate males help in the absence of observable reproductive benefits. Hamilton's concept of kin selection, whereby individuals can benefit ind...

journal_title：Nature

authors： Krakauer AH

更新日期：2005-03-03 00:00:00

abstract：:The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...

journal_title：Nature

authors： Gemelke N,Zhang X,Hung CL,Chin C

更新日期：2009-08-20 00:00:00