Inhibition of monoamine oxidase B in the brains of smokers.


:The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders and is associated with a decreased risk of Parkinson's disease. Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species. We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.






Fowler JS,Volkow ND,Wang GJ,Pappas N,Logan J,MacGregor R,Alexoff D,Shea C,Schlyer D,Wolf AP,Warner D,Zezulkova I,Cilento R




Has Abstract


1996-02-22 00:00:00














  • Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.

    abstract::Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice,...


    pub_type: 杂志文章


    authors: Guo M,Chong YE,Shapiro R,Beebe K,Yang XL,Schimmel P

    更新日期:2009-12-10 00:00:00

  • Formation of asteroid pairs by rotational fission.

    abstract::Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...


    pub_type: 杂志文章


    authors: Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

    更新日期:2010-08-26 00:00:00

  • DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1.

    abstract::The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...


    pub_type: 杂志文章


    authors: Hemmings HC Jr,Greengard P,Tung HY,Cohen P

    更新日期:1984-08-09 00:00:00

  • Human-level control through deep reinforcement learning.

    abstract::The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents...


    pub_type: 杂志文章


    authors: Mnih V,Kavukcuoglu K,Silver D,Rusu AA,Veness J,Bellemare MG,Graves A,Riedmiller M,Fidjeland AK,Ostrovski G,Petersen S,Beattie C,Sadik A,Antonoglou I,King H,Kumaran D,Wierstra D,Legg S,Hassabis D

    更新日期:2015-02-26 00:00:00

  • Snowdrift game dynamics and facultative cheating in yeast.

    abstract::The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...


    pub_type: 杂志文章


    authors: Gore J,Youk H,van Oudenaarden A

    更新日期:2009-05-14 00:00:00

  • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

    abstract::Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...


    pub_type: 杂志文章


    authors: Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

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  • Heterogeneous integration of single-crystalline complex-oxide membranes.

    abstract::Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...


    pub_type: 杂志文章


    authors: Kum HS,Lee H,Kim S,Lindemann S,Kong W,Qiao K,Chen P,Irwin J,Lee JH,Xie S,Subramanian S,Shim J,Bae SH,Choi C,Ranno L,Seo S,Lee S,Bauer J,Li H,Lee K,Robinson JA,Ross CA,Schlom DG,Rzchowski MS,Eom CB,Kim J

    更新日期:2020-02-01 00:00:00

  • Transmission dynamics of HIV infection.

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    pub_type: 杂志文章


    authors: May RM,Anderson RM

    更新日期:1987-03-12 00:00:00

  • Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.

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    pub_type: 杂志文章


    authors: Rose CR,Blum R,Pichler B,Lepier A,Kafitz KW,Konnerth A

    更新日期:2003-11-06 00:00:00

  • Non-classical correlations between single photons and phonons from a mechanical oscillator.

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    pub_type: 杂志文章


    authors: Riedinger R,Hong S,Norte RA,Slater JA,Shang J,Krause AG,Anant V,Aspelmeyer M,Gröblacher S

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  • Odour receptors and neurons for DEET and new insect repellents.

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    pub_type: 杂志文章,收录出版


    authors: Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

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  • Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.

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    pub_type: 杂志文章


    authors: Walker MD,Edlund T,Boulet AM,Rutter WJ

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    pub_type: 杂志文章,评审


    authors: Bell J

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    pub_type: 杂志文章


    authors: Rouvinski A,Guardado-Calvo P,Barba-Spaeth G,Duquerroy S,Vaney MC,Kikuti CM,Navarro Sanchez ME,Dejnirattisai W,Wongwiwat W,Haouz A,Girard-Blanc C,Petres S,Shepard WE,Desprès P,Arenzana-Seisdedos F,Dussart P,Mongkolsapaya J

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    authors: Krakauer AH

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    pub_type: 杂志文章


    authors: Melki J,Abdelhak S,Sheth P,Bachelot MF,Burlet P,Marcadet A,Aicardi J,Barois A,Carriere JP,Fardeau M

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    pub_type: 杂志文章


    authors: Abrahamson S,Wolff S

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  • Martian dust storm impact on atmospheric H2O and D/H observed by ExoMars Trace Gas Orbiter.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Lam TT,Zhou B,Wang J,Chai Y,Shen Y,Chen X,Ma C,Hong W,Chen Y,Zhang Y,Duan L,Chen P,Jiang J,Zhang Y,Li L,Poon LL,Webby RJ,Smith DK,Leung GM,Peiris JS,Holmes EC,Guan Y,Zhu H

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    pub_type: 杂志文章


    authors: Eilken HM,Nishikawa S,Schroeder T

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    pub_type: 杂志文章


    authors: Hong ST,Bang S,Hyun S,Kang J,Jeong K,Paik D,Chung J,Kim J

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    pub_type: 杂志文章


    authors: Fox PW,Hershberger SL,Bouchard TJ Jr

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    pub_type: 杂志文章


    authors: Rein A,Athan E,Benjers BM,Bassin RH,Gerwin BI,Slocum DR

    更新日期:1979-12-13 00:00:00

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    pub_type: 杂志文章


    authors: Ekland EH,Bartel DP

    更新日期:1996-07-25 00:00:00

  • The crystal structure of the bacterial chaperonin GroEL at 2.8 A.

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    pub_type: 杂志文章


    authors: Braig K,Otwinowski Z,Hegde R,Boisvert DC,Joachimiak A,Horwich AL,Sigler PB

    更新日期:1994-10-13 00:00:00

  • Rare and low-frequency coding variants alter human adult height.

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    pub_type: 杂志文章


    authors: Marouli E,Graff M,Medina-Gomez C,Lo KS,Wood AR,Kjaer TR,Fine RS,Lu Y,Schurmann C,Highland HM,Rüeger S,Thorleifsson G,Justice AE,Lamparter D,Stirrups KE,Turcot V,Young KL,Winkler TW,Esko T,Karaderi T,Locke AE,Mas

    更新日期:2017-02-09 00:00:00