Inhibition of monoamine oxidase B in the brains of smokers.

Abstract:

:The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders and is associated with a decreased risk of Parkinson's disease. Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species. We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.

journal_name

Nature

journal_title

Nature

authors

Fowler JS,Volkow ND,Wang GJ,Pappas N,Logan J,MacGregor R,Alexoff D,Shea C,Schlyer D,Wolf AP,Warner D,Zezulkova I,Cilento R

doi

10.1038/379733a0

subject

Has Abstract

pub_date

1996-02-22 00:00:00

pages

733-6

issue

6567

eissn

0028-0836

issn

1476-4687

journal_volume

379

pub_type

杂志文章

相关文献

NATURE文献大全
  • Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.

    abstract::Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice,...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08612

    authors: Guo M,Chong YE,Shapiro R,Beebe K,Yang XL,Schimmel P

    更新日期:2009-12-10 00:00:00

  • Formation of asteroid pairs by rotational fission.

    abstract::Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09315

    authors: Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

    更新日期:2010-08-26 00:00:00

  • DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1.

    abstract::The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/310503a0

    authors: Hemmings HC Jr,Greengard P,Tung HY,Cohen P

    更新日期:1984-08-09 00:00:00

  • Human-level control through deep reinforcement learning.

    abstract::The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14236

    authors: Mnih V,Kavukcuoglu K,Silver D,Rusu AA,Veness J,Bellemare MG,Graves A,Riedmiller M,Fidjeland AK,Ostrovski G,Petersen S,Beattie C,Sadik A,Antonoglou I,King H,Kumaran D,Wierstra D,Legg S,Hassabis D

    更新日期:2015-02-26 00:00:00

  • Snowdrift game dynamics and facultative cheating in yeast.

    abstract::The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07921

    authors: Gore J,Youk H,van Oudenaarden A

    更新日期:2009-05-14 00:00:00

  • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

    abstract::Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05886

    authors: Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

    更新日期:2007-06-21 00:00:00

  • Heterogeneous integration of single-crystalline complex-oxide membranes.

    abstract::Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-1939-z

    authors: Kum HS,Lee H,Kim S,Lindemann S,Kong W,Qiao K,Chen P,Irwin J,Lee JH,Xie S,Subramanian S,Shim J,Bae SH,Choi C,Ranno L,Seo S,Lee S,Bauer J,Li H,Lee K,Robinson JA,Ross CA,Schlom DG,Rzchowski MS,Eom CB,Kim J

    更新日期:2020-02-01 00:00:00

  • Transmission dynamics of HIV infection.

    abstract::Simple mathematical models of the transmission dynamics of human immunodeficiency virus help to clarify some of the essential relations between epidemiological factors, such as distributed incubation periods and heterogeneity in sexual activity, and the overall pattern of the AIDS epidemic. They also help to identify ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/326137a0

    authors: May RM,Anderson RM

    更新日期:1987-03-12 00:00:00

  • Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.

    abstract::The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic fa...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01983

    authors: Rose CR,Blum R,Pichler B,Lepier A,Kafitz KW,Konnerth A

    更新日期:2003-11-06 00:00:00

  • Non-classical correlations between single photons and phonons from a mechanical oscillator.

    abstract::Interfacing a single photon with another quantum system is a key capability in modern quantum information science. It allows quantum states of matter, such as spin states of atoms, atomic ensembles or solids, to be prepared and manipulated by photon counting and, in particular, to be distributed over long distances. S...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature16536

    authors: Riedinger R,Hong S,Norte RA,Slater JA,Shang J,Krause AG,Anant V,Aspelmeyer M,Gröblacher S

    更新日期:2016-02-18 00:00:00

  • Odour receptors and neurons for DEET and new insect repellents.

    abstract::There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

    journal_title:Nature

    pub_type: 杂志文章,收录出版

    doi:10.1038/nature12594

    authors: Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

    更新日期:2013-10-24 00:00:00

  • Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.

    abstract::DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymot...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/306557a0

    authors: Walker MD,Edlund T,Boulet AM,Rutter WJ

    更新日期:1983-12-08 00:00:00

  • Predicting disease using genomics.

    abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature02624

    authors: Bell J

    更新日期:2004-05-27 00:00:00

  • Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

    abstract::Dengue disease is caused by four different flavivirus serotypes, which infect 390 million people yearly with 25% symptomatic cases and for which no licensed vaccine is available. Recent phase III vaccine trials showed partial protection, and in particular no protection for dengue virus serotype 2 (refs 3, 4). Structur...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14130

    authors: Rouvinski A,Guardado-Calvo P,Barba-Spaeth G,Duquerroy S,Vaney MC,Kikuti CM,Navarro Sanchez ME,Dejnirattisai W,Wongwiwat W,Haouz A,Girard-Blanc C,Petres S,Shepard WE,Desprès P,Arenzana-Seisdedos F,Dussart P,Mongkolsapaya J

    更新日期:2015-04-02 00:00:00

  • Kin selection and cooperative courtship in wild turkeys.

    abstract::In the few species of birds in which males form display partnerships to attract females, one male secures most or all of the copulations. This leads to the question of why subordinate males help in the absence of observable reproductive benefits. Hamilton's concept of kin selection, whereby individuals can benefit ind...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03325

    authors: Krakauer AH

    更新日期:2005-03-03 00:00:00

  • Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q.

    abstract::Proximal spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffmann (type I), intermediate Werdnig-Hoffmann disease (type II) and Kugelberg-Welander disease (type III). Thes...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/344767a0

    authors: Melki J,Abdelhak S,Sheth P,Bachelot MF,Burlet P,Marcadet A,Aicardi J,Barois A,Carriere JP,Fardeau M

    更新日期:1990-04-19 00:00:00

  • Re-analysis of radiation-induced specific locus mutations in the mouse.

    abstract::A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/264715a0

    authors: Abrahamson S,Wolff S

    更新日期:1976-12-23 00:00:00

  • Martian dust storm impact on atmospheric H2O and D/H observed by ExoMars Trace Gas Orbiter.

    abstract::Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1097-3

    authors: Vandaele AC,Korablev O,Daerden F,Aoki S,Thomas IR,Altieri F,López-Valverde M,Villanueva G,Liuzzi G,Smith MD,Erwin JT,Trompet L,Fedorova AA,Montmessin F,Trokhimovskiy A,Belyaev DA,Ignatiev NI,Luginin M,Olsen KS,Baggi

    更新日期:2019-04-01 00:00:00

  • Endangered plants persist under phosphorus limitation.

    abstract::Nitrogen enrichment is widely thought to be responsible for the loss of plant species from temperate terrestrial ecosystems. This view is based on field surveys and controlled experiments showing that species richness correlates negatively with high productivity and nitrogen enrichment. However, as the type of nutrien...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03950

    authors: Wassen MJ,Venterink HO,Lapshina ED,Tanneberger F

    更新日期:2005-09-22 00:00:00

  • Reassembly of shattered chromosomes in Deinococcus radiodurans.

    abstract::Dehydration or desiccation is one of the most frequent and severe challenges to living cells. The bacterium Deinococcus radiodurans is the best known extremophile among the few organisms that can survive extremely high exposures to desiccation and ionizing radiation, which shatter its genome into hundreds of short DNA...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05160

    authors: Zahradka K,Slade D,Bailone A,Sommer S,Averbeck D,Petranovic M,Lindner AB,Radman M

    更新日期:2006-10-05 00:00:00

  • Rapid regulation of steroidogenesis by mitochondrial protein import.

    abstract::Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/417087a

    authors: Bose HS,Lingappa VR,Miller WL

    更新日期:2002-05-02 00:00:00

  • Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse.

    abstract::What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses, whereas graded ribbon-type synapses can sustain release and transmit information at high rates. Here we investigate...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04509

    authors: Saviane C,Silver RA

    更新日期:2006-02-23 00:00:00

  • Dissemination, divergence and establishment of H7N9 influenza viruses in China.

    abstract::Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens. Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 (refs 3-7). It is unclear ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14348

    authors: Lam TT,Zhou B,Wang J,Chai Y,Shen Y,Chen X,Ma C,Hong W,Chen Y,Zhang Y,Duan L,Chen P,Jiang J,Zhang Y,Li L,Poon LL,Webby RJ,Smith DK,Leung GM,Peiris JS,Holmes EC,Guan Y,Zhu H

    更新日期:2015-06-04 00:00:00

  • Continuous single-cell imaging of blood generation from haemogenic endothelium.

    abstract::Despite decades of research, the identity of the cells generating the first haematopoietic cells in mammalian embryos is unknown. Indeed, whether blood cells arise from mesodermal cells, mesenchymal progenitors, bipotent endothelial-haematopoietic precursors or haemogenic endothelial cells remains controversial. Proxi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07760

    authors: Eilken HM,Nishikawa S,Schroeder T

    更新日期:2009-02-12 00:00:00

  • cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila.

    abstract::Homoiotherms, for example mammals, regulate their body temperature with physiological responses such as a change of metabolic rate and sweating. In contrast, the body temperature of poikilotherms, for example Drosophila, is the result of heat exchange with the surrounding environment as a result of the large ratio of ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07090

    authors: Hong ST,Bang S,Hyun S,Kang J,Jeong K,Paik D,Chung J,Kim J

    更新日期:2008-08-07 00:00:00

  • Genetic and environmental contributions to the acquisition of a motor skill.

    abstract::Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/384356a0

    authors: Fox PW,Hershberger SL,Bouchard TJ Jr

    更新日期:1996-11-28 00:00:00

  • Isolation of a replication-defective murine leukaemia virus from cultured AKR leukaemia cells.

    abstract::Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/282753a0

    authors: Rein A,Athan E,Benjers BM,Bassin RH,Gerwin BI,Slocum DR

    更新日期:1979-12-13 00:00:00

  • RNA-catalysed RNA polymerization using nucleoside triphosphates.

    abstract::The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/382373a0

    authors: Ekland EH,Bartel DP

    更新日期:1996-07-25 00:00:00

  • The crystal structure of the bacterial chaperonin GroEL at 2.8 A.

    abstract::The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/371578a0

    authors: Braig K,Otwinowski Z,Hegde R,Boisvert DC,Joachimiak A,Horwich AL,Sigler PB

    更新日期:1994-10-13 00:00:00

  • Rare and low-frequency coding variants alter human adult height.

    abstract::Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature21039

    authors: Marouli E,Graff M,Medina-Gomez C,Lo KS,Wood AR,Kjaer TR,Fine RS,Lu Y,Schurmann C,Highland HM,Rüeger S,Thorleifsson G,Justice AE,Lamparter D,Stirrups KE,Turcot V,Young KL,Winkler TW,Esko T,Karaderi T,Locke AE,Mas

    更新日期:2017-02-09 00:00:00