Controlled growth factor release from synthetic extracellular matrices.

Abstract:

:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have been designed to operate under static conditions. We thought that polymeric matrices, which release growth factors in response to mechanical signals, might provide a new approach to guide tissue formation in mechanically stressed environments. Critical design features for this type of system include the ability to undergo repeated deformation, and a reversible binding of the protein growth factors to polymeric matrices to allow for responses to repeated stimuli. Here we report a model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation. This approach may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.

journal_name

Nature

journal_title

Nature

authors

Lee KY,Peters MC,Anderson KW,Mooney DJ

doi

10.1038/35050141

keywords:

subject

Has Abstract

pub_date

2000-12-21 00:00:00

pages

998-1000

issue

6815

eissn

0028-0836

issn

1476-4687

journal_volume

408

pub_type

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