Association of folding intermediates of glycoproteins with calnexin during protein maturation.

abstract：:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...

journal_title：Nature

authors： Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JG

更新日期：1984-02-02 00:00:00

abstract：:Devices that convert information from one form into another according to a definite procedure are known as automata. One such hypothetical device is the universal Turing machine, which stimulated work leading to the development of modern computers. The Turing machine and its special cases, including finite automata, o...

journal_title：Nature

authors： Benenson Y,Paz-Elizur T,Adar R,Keinan E,Livneh Z,Shapiro E

更新日期：2001-11-22 00:00:00

abstract：:Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...

journal_title：Nature

authors： Toms DJ

更新日期：2010-11-04 00:00:00

abstract：:The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods...

journal_title：Nature

authors： Bakken TE,Miller JA,Ding SL,Sunkin SM,Smith KA,Ng L,Szafer A,Dalley RA,Royall JJ,Lemon T,Shapouri S,Aiona K,Arnold J,Bennett JL,Bertagnolli D,Bickley K,Boe A,Brouner K,Butler S,Byrnes E,Caldejon S,Carey A,Cate

更新日期：2016-07-21 00:00:00

abstract：:Fluids and melts liberated from subducting oceanic crust recycle lithophile elements back into the mantle wedge, facilitate melting and ultimately lead to prolific subduction-zone arc volcanism. The nature and composition of the mobile phases generated in the subducting slab at high pressures have, however, remained l...

journal_title：Nature

authors： Kessel R,Schmidt MW,Ulmer P,Pettke T

更新日期：2005-09-29 00:00:00

abstract：:Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipient's immune-surveillance system. Here we report a me...

journal_title：Nature

authors： Hojo M,Morimoto T,Maluccio M,Asano T,Morimoto K,Lagman M,Shimbo T,Suthanthiran M

更新日期：1999-02-11 00:00:00

abstract：:The microscopic origin of superconductivity in the high-transition-temperature (high-T(c)) copper oxides remains the subject of active inquiry; several of their electronic characteristics are well established as universal to all the known materials, forming the experimental foundation that all theories must address. T...

journal_title：Nature

authors： Schaak RE,Klimczuk T,Foo ML,Cava RJ

更新日期：2003-07-31 00:00:00

abstract：:The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse applications in quantum computing and communications1. However, fluorescent nanodiamonds also have attractive properties for in vitro biosensing, including brightness2, low cost3 and selective manipulation of their emission4. Nanoparticl...

journal_title：Nature

authors： Miller BS,Bezinge L,Gliddon HD,Huang D,Dold G,Gray ER,Heaney J,Dobson PJ,Nastouli E,Morton JJL,McKendry RA

更新日期：2020-11-01 00:00:00

abstract：:Fas is a type-I membrane protein that transduces an apoptotic signal. Binding of Fas ligand or agonistic anti-Fas antibody to Fas kills the cells by apoptosis. Studies in the nematode Caenorhabditis elegans have suggested that proteases such as interleukin-1 beta-converting enzyme (ICE) or the product of the C. elegan...

journal_title：Nature

authors： Enari M,Hug H,Nagata S

更新日期：1995-05-04 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:The loose material--regolith--on the surfaces of asteroids is thought to represent ballistically emplaced ejecta from impacts but the identification of source craters and the detailed study of the regolith modification have been hampered by the limited spatial resolution and area coverage of the few asteroids imaged b...

journal_title：Nature

authors： Thomas PC,Veverka J,Robinson MS,Murchie S

更新日期：2001-09-27 00:00:00

abstract：:The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...

journal_title：Nature

authors： Song R,Walentek P,Sponer N,Klimke A,Lee JS,Dixon G,Harland R,Wan Y,Lishko P,Lize M,Kessel M,He L

更新日期：2014-06-05 00:00:00

abstract：:The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

journal_title：Nature

authors： Gros P,Ben Neriah YB,Croop JM,Housman DE

更新日期：1986-10-23 00:00:00

abstract：:Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking o...

journal_title：Nature

authors： Bannister AJ,Kouzarides T

更新日期：2005-08-25 00:00:00

abstract：:RNase P is the only endonuclease responsible for processing the 5' end of transfer RNA by cleaving a precursor and leading to tRNA maturation. It contains an RNA component and a protein component and has been identified in all organisms. It was one of the first catalytic RNAs identified and the first that acts as a mu...

journal_title：Nature

authors： Krasilnikov AS,Yang X,Pan T,Mondragón A

更新日期：2003-02-13 00:00:00

abstract：:We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixel...

journal_title：Nature

authors： Levskaya A,Chevalier AA,Tabor JJ,Simpson ZB,Lavery LA,Levy M,Davidson EA,Scouras A,Ellington AD,Marcotte EM,Voigt CA

更新日期：2005-11-24 00:00:00

abstract：:HIV-1 protease processes the Gag and Gag-Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation. The mature protease is active only as a dimer with each subunit contributing catalytic residues. The full-length transframe region protease pr...

journal_title：Nature

authors： Tang C,Louis JM,Aniana A,Suh JY,Clore GM

更新日期：2008-10-02 00:00:00

abstract：:The determination of molecular masses from barometric sedimentation profiles, a main topic in ultracentrifugal analysis, is thought to be quantitatively correct for non-interacting particles. Whereas this expectation is justified for uncharged colloids or macromolecules at low volume fractions, early ultracentrifugati...

journal_title：Nature

authors： Raşa M,Philipse AP

更新日期：2004-06-24 00:00:00

abstract：:The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...

journal_title：Nature

authors： Mullighan CG,Miller CB,Radtke I,Phillips LA,Dalton J,Ma J,White D,Hughes TP,Le Beau MM,Pui CH,Relling MV,Shurtleff SA,Downing JR

更新日期：2008-05-01 00:00:00

abstract：:Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of...

journal_title：Nature

authors： Contreras FX,Ernst AM,Haberkant P,Björkholm P,Lindahl E,Gönen B,Tischer C,Elofsson A,von Heijne G,Thiele C,Pepperkok R,Wieland F,Brügger B

更新日期：2012-01-09 00:00:00

abstract：:Cellular ras genes encode a family of membrane-associated proteins (p21ras) that bind guanine nucleotide and possess a low intrinsic GTPase activity. The p21ras proteins are ubiquitously expressed in mammalian cells and are thought to be involved in a growth-promoting signal transduction pathway; their mode of action,...

journal_title：Nature

authors： Graziadei L,Riabowol K,Bar-Sagi D

更新日期：1990-09-27 00:00:00

abstract：:The T-cell receptor (TCR) repertoire is selected in the thymus after rearrangement of genes encoding TCR alpha and beta chains. Selection is based on the recognition by newly emergent T cells of self-ligands associated with molecules of the major histocompatibility complex: some combinations result in positive selecti...

journal_title：Nature

authors： Dyson PJ,Knight AM,Fairchild S,Simpson E,Tomonari K

更新日期：1991-02-07 00:00:00

abstract：:The coupling of ATP hydrolysis to electron transfer by the enzyme nitrogenase during biological nitrogen fixation is an important example of a nucleotide-dependent transduction mechanism. The crystal structure has been determined for the complex between the Fe-protein and MoFe-protein components of nitrogenase stabili...

journal_title：Nature

authors： Schindelin H,Kisker C,Schlessman JL,Howard JB,Rees DC

更新日期：1997-05-22 00:00:00

abstract：:A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...

journal_title：Nature

authors： Vogel AB,Kanevsky I,Che Y,Swanson KA,Muik A,Vormehr M,Kranz LM,Walzer KC,Hein S,Güler A,Loschko J,Maddur MS,Ota-Setlik A,Tompkins K,Cole J,Lui BG,Ziegenhals T,Plaschke A,Eisel D,Dany SC,Fesser S,Erbar S,Bates

更新日期：2021-02-01 00:00:00

abstract：:Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-l...

journal_title：Nature

authors： Soda M,Choi YL,Enomoto M,Takada S,Yamashita Y,Ishikawa S,Fujiwara S,Watanabe H,Kurashina K,Hatanaka H,Bando M,Ohno S,Ishikawa Y,Aburatani H,Niki T,Sohara Y,Sugiyama Y,Mano H

更新日期：2007-08-02 00:00:00

abstract：:Developing an optical amplifier on silicon is essential for the success of silicon-on-insulator (SOI) photonic integrated circuits. Recently, optical gain with a 1-nm bandwidth was demonstrated using the Raman effect, which led to the demonstration of a Raman oscillator, lossless optical modulation and optically tunab...

journal_title：Nature

authors： Foster MA,Turner AC,Sharping JE,Schmidt BS,Lipson M,Gaeta AL

更新日期：2006-06-22 00:00:00

abstract：:The yeast nuclear protein Yra1p is an essential export factor for mRNA. Yra1p interacts directly with the mRNA transport factor Mex67p/Mtr2p, which is associated with the nuclear pore. Here, we report a genetic interaction between YRA1 and SUB2, the gene for a DEAD box helicase involved in splicing. Mutation of SUB2 a...

journal_title：Nature

authors： Strässer K,Hurt E

更新日期：2001-10-11 00:00:00

abstract：:Transparent electronic devices formed on flexible substrates are expected to meet emerging technological demands where silicon-based electronics cannot provide a solution. Examples of active flexible applications include paper displays and wearable computers. So far, mainly flexible devices based on hydrogenated amorp...

journal_title：Nature

authors： Nomura K,Ohta H,Takagi A,Kamiya T,Hirano M,Hosono H

更新日期：2004-11-25 00:00:00

abstract：:Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie phenotypic variation. Moreover, wild strains of the plant Arabidopsis thaliana differ in many epialleles, and these can influence the expression of nearby genes. However, to understand their role in evolution, it is imperative ...

journal_title：Nature

authors： Becker C,Hagmann J,Müller J,Koenig D,Stegle O,Borgwardt K,Weigel D

更新日期：2011-09-20 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00