Diet-microbiota interactions as moderators of human metabolism.

abstract：:Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...

journal_title：Nature

authors： Wu Y,Vendome J,Shapiro L,Ben-Shaul A,Honig B

更新日期：2011-07-27 00:00:00

abstract：:Electron transfer reactions are essential for life because they underpin oxidative phosphorylation and photosynthesis, processes leading to the generation of ATP, and are involved in many reactions of intermediary metabolism. Key to these roles is the formation of transient inter-protein electron transfer complexes. T...

journal_title：Nature

authors： Antonyuk SV,Han C,Eady RR,Hasnain SS

更新日期：2013-04-04 00:00:00

abstract：:AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...

journal_title：Nature

authors： Ilundain A,Naftalin RJ

更新日期：1979-05-31 00:00:00

abstract：:Nuclear exclusion of the PTEN (phosphatase and tensin homologue deleted in chromosome 10) tumour suppressor has been associated with cancer progression. However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN a...

journal_title：Nature

authors： Song MS,Salmena L,Carracedo A,Egia A,Lo-Coco F,Teruya-Feldstein J,Pandolfi PP

更新日期：2008-10-09 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...

journal_title：Nature

authors： Song X,Jensen MØ,Jogini V,Stein RA,Lee CH,Mchaourab HS,Shaw DE,Gouaux E

更新日期：2018-04-01 00:00:00

abstract：:Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events1-3. However, there is limited understanding of the mechanisms by which experience drives circuit reorganization to establish a network of Fos-activated cells. It i...

journal_title：Nature

authors： Yap EL,Pettit NL,Davis CP,Nagy MA,Harmin DA,Golden E,Dagliyan O,Lin C,Rudolph S,Sharma N,Griffith EC,Harvey CD,Greenberg ME

更新日期：2020-12-09 00:00:00

abstract：:Eukaryotic structural gene mutations occurring spontaneously in a mouse myeloma cell line offer the opportunity to study somatic mutation in animal cells at the molecular level. Studies on the myeloma protein and on mRNA have enabled us to characterise four such mutants representing four different mutation mechanisms....

journal_title：Nature

authors： Adetugbo K,Milstein C,Secher DS

更新日期：1977-01-27 00:00:00

abstract：:It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer d...

journal_title：Nature

authors： Papitto A,Ferrigno C,Bozzo E,Rea N,Pavan L,Burderi L,Burgay M,Campana S,Di Salvo T,Falanga M,Filipović MD,Freire PC,Hessels JW,Possenti A,Ransom SM,Riggio A,Romano P,Sarkissian JM,Stairs IH,Stella L,Torres DF,Wi

更新日期：2013-09-26 00:00:00

abstract：:Skeletal muscles consist of motor units which may differ considerably in contractile properties and types of usage. Some units participate mainly in relatively rare, quick movements and contract rapidly and are easily fatigued (type FF); others contribute to the maintenance of posture and hence contract slowly and are...

journal_title：Nature

authors： Hennig R,Lømo T

更新日期：1985-03-14 00:00:00

abstract：:Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with repetitive segments flanked by conserved non-repetitive domains. Spidroins are stored as a highly concentrated fluid dope. On silk formation, intermolecular interactions between repeat regions are established that provide st...

journal_title：Nature

authors： Askarieh G,Hedhammar M,Nordling K,Saenz A,Casals C,Rising A,Johansson J,Knight SD

更新日期：2010-05-13 00:00:00

abstract：:Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...

journal_title：Nature

authors： Ueda HR,Chen W,Adachi A,Wakamatsu H,Hayashi S,Takasugi T,Nagano M,Nakahama K,Suzuki Y,Sugano S,Iino M,Shigeyoshi Y,Hashimoto S

更新日期：2002-08-01 00:00:00

abstract：:The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K isoforms in organismal physiology and disease are unknown. To delineate the role of p110alpha, a ubiquitously expressed PI(3)...

journal_title：Nature

authors： Foukas LC,Claret M,Pearce W,Okkenhaug K,Meek S,Peskett E,Sancho S,Smith AJ,Withers DJ,Vanhaesebroeck B

更新日期：2006-05-18 00:00:00

abstract：:The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius), however, ranged widely and it is unknown whether it was domesticated within Europe as one feature of a local contribution t...

journal_title：Nature

authors： Troy CS,MacHugh DE,Bailey JF,Magee DA,Loftus RT,Cunningham P,Chamberlain AT,Sykes BC,Bradley DG

更新日期：2001-04-26 00:00:00

abstract：:B lymphocytes originate from pluripotential haematopoietic stem cells and differentiate into immunoglobulin (Ig)-producing cells. B-cell lineage differentiation is accompanied by two types of immunoglobulin gene rearrangements--rearrangement of V, D and J gene segments to create a functional V gene and rearrangement o...

journal_title：Nature

authors： Sugiyama H,Akira S,Kikutani H,Kishimoto S,Yamamura Y,Kishimoto T

更新日期：1983-06-30 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:The axial coupling of the nucleon, gA, is the strength of its coupling to the weak axial current of the standard model of particle physics, in much the same way as the electric charge is the strength of the coupling to the electromagnetic current. This axial coupling dictates the rate at which neutrons decay to proton...

journal_title：Nature

authors： Chang CC,Nicholson AN,Rinaldi E,Berkowitz E,Garron N,Brantley DA,Monge-Camacho H,Monahan CJ,Bouchard C,Clark MA,Joó B,Kurth T,Orginos K,Vranas P,Walker-Loud A

更新日期：2018-06-01 00:00:00

abstract：:The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...

journal_title：Nature

authors： Magurran AE,Henderson PA

更新日期：2003-04-17 00:00:00

abstract：:The precursor frequency of T cells specific for any given foreign antigen is, in general, extremely low. Prominent exceptions to this rule are the T cells that are specific for foreign major histocompatibility complex (MHC) products or for products of the minor lymphocyte stimulatory (Mls) genes in the mouse which are...

journal_title：Nature

authors： Abe R,Vacchio MS,Fox B,Hodes RJ

更新日期：1988-10-27 00:00:00

abstract：:Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for neurobiologists. It has long been hoped that identifying alleles that confer increased risk of such disorders would provide clues for neurobiological investigation. But this quest has been stymied by a lack of validated biologi...

journal_title：Nature

authors： Hyman SE

更新日期：2008-10-16 00:00:00

abstract：:H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...

journal_title：Nature

authors： Allen H,Wraith D,Pala P,Askonas B,Flavell RA

更新日期：1984-05-17 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...

journal_title：Nature

authors： Krege JH,John SW,Langenbach LL,Hodgin JB,Hagaman JR,Bachman ES,Jennette JC,O'Brien DA,Smithies O

更新日期：1995-05-11 00:00:00

abstract：:Deuterostomes are a remarkably diverse super-phylum, including not only the chordates (to which we belong) but groups as disparate as the echinoderms and the hemichordates. The phylogeny of deuterostomes is now achieving some degree of stability, especially on account of new molecular data, but this leaves as conjectu...

journal_title：Nature

authors： Shu DG,Morris SC,Han J,Zhang ZF,Liu JN

更新日期：2004-07-22 00:00:00

abstract：:The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtaine...

journal_title：Nature

authors： Tesar PJ,Chenoweth JG,Brook FA,Davies TJ,Evans EP,Mack DL,Gardner RL,McKay RD

更新日期：2007-07-12 00:00:00

abstract：:Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...

journal_title：Nature

authors： Barclay T,Rowe JF,Lissauer JJ,Huber D,Fressin F,Howell SB,Bryson ST,Chaplin WJ,Désert JM,Lopez ED,Marcy GW,Mullally F,Ragozzine D,Torres G,Adams ER,Agol E,Barrado D,Basu S,Bedding TR,Buchhave LA,Charbonneau D,Ch

更新日期：2013-02-28 00:00:00

abstract：:Cytotoxic T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompatibility complex (MHC) which were present during anti-viral sensitisation in vivo. This 'associative recognition' by cytotoxic T cells could ref...

journal_title：Nature

authors： Koszinowski U,Gething MJ,Waterfield M

更新日期：1977-05-12 00:00:00

abstract：:Although the link between long gamma-ray bursts (GRBs) and supernovae has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a gamma-ray burst emerges from the star's surface, nor ho...

journal_title：Nature

authors： Campana S,Mangano V,Blustin AJ,Brown P,Burrows DN,Chincarini G,Cummings JR,Cusumano G,Della Valle M,Malesani D,Mészáros P,Nousek JA,Page M,Sakamoto T,Waxman E,Zhang B,Dai ZG,Gehrels N,Immler S,Marshall FE,Mason KO

更新日期：2006-08-31 00:00:00

abstract：:Exploring visual illusions reveals fundamental principles of cortical processing. Illusory motion perception of non-moving stimuli was described almost a century ago by Gestalt psychologists. However, the underlying neuronal mechanisms remain unknown. To explore cortical mechanisms underlying the 'line-motion' illusio...

journal_title：Nature

authors： Jancke D,Chavane F,Naaman S,Grinvald A

更新日期：2004-03-25 00:00:00

abstract：:The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...

journal_title：Nature

authors： Windass JD,Worsey MJ,Pioli EM,Pioli D,Barth PT,Atherton KT,Dart EC,Byrom D,Powell K,Senior PJ

更新日期：1980-10-02 00:00:00

abstract：:Human T-cell leukaemia virus (HTLV), first isolated in the United States from a patient with cutaneous T-cell lymphoma, is a unique horizontally transmitted retrovirus which is highly associated with certain adult T-cell malignancies. Also, HTLV can be transmitted in vitro to cord blood T-lymphocytes. In the accompany...

journal_title：Nature

authors： Clarke MF,Gelmann EP,Reitz MS Jr

更新日期：1983-09-01 00:00:00