How broken sleep promotes cardiovascular disease.

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Neuropeptide Y (NPY) has a number of functions in mammalian physiology. Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support. Mice wit...

journal_title：Nature

authors： Hansel DE,Eipper BA,Ronnett GV

更新日期：2001-04-19 00:00:00

abstract：:Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I foot...

journal_title：Nature

authors： Vierstra J,Lazar J,Sandstrom R,Halow J,Lee K,Bates D,Diegel M,Dunn D,Neri F,Haugen E,Rynes E,Reynolds A,Nelson J,Johnson A,Frerker M,Buckley M,Kaul R,Meuleman W,Stamatoyannopoulos JA

更新日期：2020-07-01 00:00:00

abstract：:Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...

journal_title：Nature

authors： Maruŝić-Galesić S,Stephany DA,Longo DL,Kruisbeek AM

更新日期：1988-05-12 00:00:00

abstract：:DNA winds about itself in a right-handed or left-handed fashion at several structural levels. The double helix is generally right-handed and is given a (+) sign by convention, whereas supercoiling of the helix axis is always (-) in the cell. The winding in higher -order forms such as knots and catenanes is unknown, an...

journal_title：Nature

authors： Krasnow MA,Stasiak A,Spengler SJ,Dean F,Koller T,Cozzarelli NR

更新日期：1983-08-11 00:00:00

abstract：:Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...

journal_title：Nature

authors： Winklbauer R,Medina A,Swain RK,Steinbeisser H

更新日期：2001-10-25 00:00:00

abstract：:Highly collimated parsec-scale jets, which are generally linked to the presence of an accretion disk, are commonly observed in low-mass young stellar objects. In the past two decades, a few of these jets have been directly (or indirectly) observed from higher-mass (larger than eight solar masses) young stellar objects...

journal_title：Nature

authors： McLeod AF,Reiter M,Kuiper R,Klaassen PD,Evans CJ

更新日期：2018-02-15 00:00:00

abstract：:Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathw...

journal_title：Nature

authors： Metcalf D,Greenhalgh CJ,Viney E,Willson TA,Starr R,Nicola NA,Hilton DJ,Alexander WS

更新日期：2000-06-29 00:00:00

abstract：:Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species. ...

journal_title：Nature

authors： Prince AM,Moor-Jankowski J,Eichberg JW,Schellekens H,Mauler RF,Girard M,Goodall J

更新日期：1988-06-09 00:00:00

abstract：:In Extended Data Fig. 5d of this Letter, the blots for anti-pS612 and anti-BAK1 were inadvertently duplicated. This figure has been corrected online. ...

journal_title：Nature

authors： Perraki A,DeFalco TA,Derbyshire P,Avila J,Séré D,Sklenar J,Qi X,Stransfeld L,Schwessinger B,Kadota Y,Macho AP,Jiang S,Couto D,Torii KU,Menke FLH,Zipfel C

更新日期：2018-11-01 00:00:00

abstract：:There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with a potent and novel spectrum of antimalarial activity against multipl...

journal_title：Nature

authors： Baragaña B,Hallyburton I,Lee MC,Norcross NR,Grimaldi R,Otto TD,Proto WR,Blagborough AM,Meister S,Wirjanata G,Ruecker A,Upton LM,Abraham TS,Almeida MJ,Pradhan A,Porzelle A,Luksch T,Martínez MS,Luksch T,Bolscher JM,

更新日期：2015-06-18 00:00:00

abstract：:Temperature is a primary driver of the distribution of biodiversity as well as of ecosystem boundaries. Declining temperature with increasing elevation in montane systems has long been recognized as a major factor shaping plant community biodiversity, metabolic processes, and ecosystem dynamics. Elevational gradients,...

journal_title：Nature

authors： Mayor JR,Sanders NJ,Classen AT,Bardgett RD,Clément JC,Fajardo A,Lavorel S,Sundqvist MK,Bahn M,Chisholm C,Cieraad E,Gedalof Z,Grigulis K,Kudo G,Oberski DL,Wardle DA

更新日期：2017-02-02 00:00:00

abstract：:Regulation of ion transport by phosphorylation and G proteins occurs in several epithelial and non-epithelial cell plasma membranes1-5. It is not known whether transporters on intracellular membranes are target sites for second messengers. Here we present direct evidence that a chloride conductance in endocytic vesicl...

journal_title：Nature

authors： Bae HR,Verkman AS

更新日期：1990-12-13 00:00:00

abstract：:Neuroblastoma, the most common paediatric solid tumour, arises from defective neural crest cells. Genetic alterations occur frequently in the most aggressive neuroblastomas. In particular, deletion or suppression of the proapoptotic enzyme caspase-8 is common in malignant, disseminated disease, although the effect of ...

journal_title：Nature

authors： Stupack DG,Teitz T,Potter MD,Mikolon D,Houghton PJ,Kidd VJ,Lahti JM,Cheresh DA

更新日期：2006-01-05 00:00:00

abstract：:Most stars become white dwarfs after they have exhausted their nuclear fuel (the Sun will be one such). Between one-quarter and one-half of white dwarfs have elements heavier than helium in their atmospheres, even though these elements ought to sink rapidly into the stellar interiors (unless they are occasionally repl...

journal_title：Nature

authors： Vanderburg A,Johnson JA,Rappaport S,Bieryla A,Irwin J,Lewis JA,Kipping D,Brown WR,Dufour P,Ciardi DR,Angus R,Schaefer L,Latham DW,Charbonneau D,Beichman C,Eastman J,McCrady N,Wittenmyer RA,Wright JT

更新日期：2015-10-22 00:00:00

abstract：:Some Pacific island societies, such as those of Easter Island and Mangareva, inadvertently contributed to their own collapse by causing massive deforestation. Others retained forest cover and survived. How can those fateful differences be explained? Although the answers undoubtedly involve both different cultural resp...

journal_title：Nature

authors： Rolett B,Diamond J

更新日期：2004-09-23 00:00:00

abstract：:The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (...

journal_title：Nature

authors： Warren TK,Jordan R,Lo MK,Ray AS,Mackman RL,Soloveva V,Siegel D,Perron M,Bannister R,Hui HC,Larson N,Strickley R,Wells J,Stuthman KS,Van Tongeren SA,Garza NL,Donnelly G,Shurtleff AC,Retterer CJ,Gharaibeh D,Zamani R

更新日期：2016-03-17 00:00:00

abstract：:The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...

journal_title：Nature

authors： Noll KS,Roush TL,Cruikshank DP,Johnson RE,Pendleton YJ

更新日期：1997-07-03 00:00:00

abstract：:Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...

journal_title：Nature

authors： Wagner RW

更新日期：1994-11-24 00:00:00

abstract：:Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopam...

journal_title：Nature

authors： Sunahara RK,Niznik HB,Weiner DM,Stormann TM,Brann MR,Kennedy JL,Gelernter JE,Rozmahel R,Yang YL,Israel Y

更新日期：1990-09-06 00:00:00

abstract：:Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...

journal_title：Nature

authors： Das Thakur M,Salangsang F,Landman AS,Sellers WR,Pryer NK,Levesque MP,Dummer R,McMahon M,Stuart DD

更新日期：2013-02-14 00:00:00

abstract：:The dehydration of subducting oceanic crust and upper mantle has been inferred both to promote the partial melting leading to arc magmatism and to induce intraslab intermediate-depth earthquakes, at depths of 50-300 km. Yet there is still no consensus about how slab hydration occurs or where and how much chemically bo...

journal_title：Nature

authors： Ranero CR,Morgan JP,McIntosh K,Reichert C

更新日期：2003-09-25 00:00:00

abstract：:A wide variety of voltage-gated K+ channels are involved in the regulation of neuronal excitability and synaptic transmission. Their heterogeneity arises in part from the large number of genes encoding different K+ channel subunits (reviewed in ref. 1). In addition, heterologous expression studies indicate that assemb...

journal_title：Nature

authors： Sheng M,Liao YJ,Jan YN,Jan LY

更新日期：1993-09-02 00:00:00

abstract：:Microscopic diamond was recently discovered in oxidized acid residues from several carbonaceous chondrite meteorites (for example, the C delta component of the Allende meteorite). Some of the reported properties of C delta seem in conflict with those expected of diamond. Here we present high spatial resolution analy...

journal_title：Nature

authors： Blake DF,Freund F,Krishnan KF,Echer CJ,Shipp R,Bunch TE,Tielens AG,Lipari RJ,Hetherington CJ,Chang S

更新日期：1988-04-14 00:00:00

abstract：:The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...

journal_title：Nature

authors： Mullighan CG,Miller CB,Radtke I,Phillips LA,Dalton J,Ma J,White D,Hughes TP,Le Beau MM,Pui CH,Relling MV,Shurtleff SA,Downing JR

更新日期：2008-05-01 00:00:00

abstract：:In the adult brain, new synapses are formed and pre-existing ones are lost, but the function of this structural plasticity has remained unclear. Learning of new skills is correlated with formation of new synapses. These may directly encode new memories, but they may also have more general roles in memory encoding and ...

journal_title：Nature

authors： Ruediger S,Vittori C,Bednarek E,Genoud C,Strata P,Sacchetti B,Caroni P

更新日期：2011-05-26 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:The oxygen evolution reaction has an important role in many alternative-energy schemes because it supplies the protons and electrons required for converting renewable electricity into chemical fuels1-3. Electrocatalysts accelerate the reaction by facilitating the required electron transfer4, as well as the formation a...

journal_title：Nature

authors： Nong HN,Falling LJ,Bergmann A,Klingenhof M,Tran HP,Spöri C,Mom R,Timoshenko J,Zichittella G,Knop-Gericke A,Piccinin S,Pérez-Ramírez J,Cuenya BR,Schlögl R,Strasser P,Teschner D,Jones TE

更新日期：2020-11-01 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...

journal_title：Nature

authors： Paleg LG,Aspinall D

更新日期：1970-12-05 00:00:00