Potentiation of neuroblastoma metastasis by loss of caspase-8.

abstract：:Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...

journal_title：Nature

authors： Berry MP,Graham CM,McNab FW,Xu Z,Bloch SA,Oni T,Wilkinson KA,Banchereau R,Skinner J,Wilkinson RJ,Quinn C,Blankenship D,Dhawan R,Cush JJ,Mejias A,Ramilo O,Kon OM,Pascual V,Banchereau J,Chaussabel D,O'Garra A

更新日期：2010-08-19 00:00:00

abstract：:Diatremes are carrot-shaped bodies forming the upper parts of very deep magmatic intrusions of kimberlite rock. These unusual, enigmatic and complex features are famous as the source of diamonds. Here we present a new model of kimberlite ascent and eruption, emphasizing the extremely unsteady nature of this process to...

journal_title：Nature

authors： Wilson L,Head Iii JW 3rd

更新日期：2007-05-03 00:00:00

abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...

journal_title：Nature

authors： Rauner N,Meuris M,Zoric M,Tiller JC

更新日期：2017-03-16 00:00:00

abstract：:The chemical composition of basaltic magma erupted at the Earth's surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal assimilation at lower pressures. It has been proposed that studyi...

journal_title：Nature

authors： Spandler C,O'Neill HS,Kamenetsky VS

更新日期：2007-05-17 00:00:00

abstract：:The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a mo...

journal_title：Nature

authors： Marinari E,Mehonic A,Curran S,Gale J,Duke T,Baum B

更新日期：2012-04-15 00:00:00

abstract：:Most of what is known about the evolution of deinonychosaurs (that is, the group of theropods most closely related to birds) is based on discoveries from North America and Asia. Except for Unenlagia comahuensis and some fragmentary remains from northern Africa, no other evidence was available on deinonychosaurian dive...

journal_title：Nature

authors： Novas FE,Pol D

更新日期：2005-02-24 00:00:00

abstract：:Soybean (Glycine max (L.) Merr.) is an important crop that provides a sustainable source of protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a microscopic roundworm that feeds on the roots of soybean and is a major constraint to soybean production. This nematode causes more than US$1 ...

journal_title：Nature

authors： Liu S,Kandoth PK,Warren SD,Yeckel G,Heinz R,Alden J,Yang C,Jamai A,El-Mellouki T,Juvale PS,Hill J,Baum TJ,Cianzio S,Whitham SA,Korkin D,Mitchum MG,Meksem K

更新日期：2012-12-13 00:00:00

abstract：:Human activities are causing Earth's sixth major extinction event-an accelerating decline of the world's stocks of biological diversity at rates 100 to 1,000 times pre-human levels. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space. However, in today's in...

journal_title：Nature

authors： Lenzen M,Moran D,Kanemoto K,Foran B,Lobefaro L,Geschke A

更新日期：2012-06-06 00:00:00

abstract：:Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

journal_title：Nature

authors： Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

更新日期：2001-06-07 00:00:00

abstract：:Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the develope...

journal_title：Nature

authors： Mackman N

更新日期：2008-02-21 00:00:00

abstract：:Cosmid, yeast artificial chromosome (YAC), P1 and complementary DNA (cDNA) libraries are distributed on high-density filters to the scientific community and experimental results are stored in a common object-based database accessible through the Internet. ...

journal_title：Nature

authors： Zehetner G,Lehrach H

更新日期：1994-02-03 00:00:00

abstract：:Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome. However, it remains unclear how th...

journal_title：Nature

authors： Numata T,Ikeuchi Y,Fukai S,Suzuki T,Nureki O

更新日期：2006-07-27 00:00:00

abstract：:5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...

journal_title：Nature

authors： Lummis SC,Beene DL,Lee LW,Lester HA,Broadhurst RW,Dougherty DA

更新日期：2005-11-10 00:00:00

abstract：:The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that the analgesic effect of opioids on the PAG works by suppressing the inhibitory influence of the neurotransmitter GABA (gamm...

journal_title：Nature

authors： Vaughan CW,Ingram SL,Connor MA,Christie MJ

更新日期：1997-12-11 00:00:00

abstract：:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly e...

journal_title：Nature

authors： Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P

更新日期：1996-03-14 00:00:00

abstract：:During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

journal_title：Nature

authors： Bina CR,Navrotsky A

更新日期：2000-12-14 00:00:00

abstract：:Human T-cell leukaemia virus (HTLV), first isolated in the United States from a patient with cutaneous T-cell lymphoma, is a unique horizontally transmitted retrovirus which is highly associated with certain adult T-cell malignancies. Also, HTLV can be transmitted in vitro to cord blood T-lymphocytes. In the accompany...

journal_title：Nature

authors： Clarke MF,Gelmann EP,Reitz MS Jr

更新日期：1983-09-01 00:00:00

abstract：:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...

journal_title：Nature

authors： Kolokotrones T,Van Savage,Deeds EJ,Fontana W

更新日期：2010-04-01 00:00:00

abstract：:Macrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens. Macrophages use Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns--including bacterial cell wall components, such as lipopolysaccharide or lipoteichoic acid, and vir...

journal_title：Nature

authors： Hsu LC,Park JM,Zhang K,Luo JL,Maeda S,Kaufman RJ,Eckmann L,Guiney DG,Karin M

更新日期：2004-03-18 00:00:00

abstract：:Plate tectonics successfully describes the surface of Earth as a mosaic of moving lithospheric plates. But it is not clear what happens at the base of the plates, the lithosphere-asthenosphere boundary (LAB). The LAB has been well imaged with converted teleseismic waves, whose 10-40-kilometre wavelength controls the s...

journal_title：Nature

authors： Stern TA,Henrys SA,Okaya D,Louie JN,Savage MK,Lamb S,Sato H,Sutherland R,Iwasaki T

更新日期：2015-02-05 00:00:00

abstract：:Human epithelia are permanently challenged by bacteria and fungi, including commensal and pathogenic microbiota. In the gut, the fraction of strict anaerobes increases from proximal to distal, reaching 99% of bacterial species in the colon. At colonic mucosa, oxygen partial pressure is below 25% of airborne oxygen con...

journal_title：Nature

authors： Schroeder BO,Wu Z,Nuding S,Groscurth S,Marcinowski M,Beisner J,Buchner J,Schaller M,Stange EF,Wehkamp J

更新日期：2011-01-20 00:00:00

abstract：:A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...

journal_title：Nature

authors： Wagner CE,Harmon LJ,Seehausen O

更新日期：2012-07-19 00:00:00

abstract：:Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...

journal_title：Nature

authors： James AA,Morrison PT,Kolodner R

更新日期：1983-05-19 00:00:00

abstract：:It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...

journal_title：Nature

authors： Folkard S,Hume KI,Minors DS,Waterhouse JM,Watson FL

更新日期：1985-02-21 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Aggregation of amyloid-β peptides into fibrils or other self-assembled states is central to the pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40- and 42-residue amyloid-β peptides (Aβ40 and Aβ42) are polymorphic, with variations in molecular structure that depend on fibril growth conditions. Recent e...

journal_title：Nature

authors： Qiang W,Yau WM,Lu JX,Collinge J,Tycko R

更新日期：2017-01-12 00:00:00

abstract：:The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect ...

journal_title：Nature

authors： Feizi T

更新日期：1985-03-07 00:00:00

abstract：:In Xenopus the c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the progression from meiosis I to meiosis II and for the second meiotic metaphase arrest, acting as an essential component of the cytostatic factor CSF. Its function in mouse oocytes is unclear, however, as is t...

journal_title：Nature

authors： Hashimoto N,Watanabe N,Furuta Y,Tamemoto H,Sagata N,Yokoyama M,Okazaki K,Nagayoshi M,Takeda N,Ikawa Y

更新日期：1994-07-07 00:00:00

abstract：:Eukaryotic transfer RNA genes have two internal discontinuous control regions, the A and B blocks, which correspond approximately to the D-stem and the pseudo-U arm of tRNA. In reconstituted transcription systems at least two components are required to direct accurate initiation by RNA polymerase (refs 4,5). However, ...

journal_title：Nature

authors： Smagowicz W,Ruet A,Camier S,Sentenac A,Fromageot P,Sternbach H

更新日期：1983-08-25 00:00:00

abstract：:Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...

journal_title：Nature

authors： Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

更新日期：2005-02-03 00:00:00