Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice.


:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly expressed in postmeiotic cells, and CREM may be responsible for the activation of several haploid germ cell-specific genes involved in the structuring of the spermatozoon. The specific role of CREM in spermiogenesis was addressed using CREM-mutant mice generated by homologous recombination. Analysis of the seminiferous epithelium in mutant male mice reveals postmeiotic arrest at the first step of spermiogenesis. Late spermatids are completely absent, and there is a significant increase in apoptotic germ cells. We show that CREM deficiency results in the lack of postmeiotic cell-specific gene expression. The complete lack of spermatozoa in the mutant mice is reminiscent of cases of human infertility.






Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P




Has Abstract


1996-03-14 00:00:00














  • Extra-helical binding site of a glucagon receptor antagonist.

    abstract::Glucagon is a 29-amino-acid peptide released from the α-cells of the islet of Langerhans, which has a key role in glucose homeostasis. Glucagon action is transduced by the class B G-protein-coupled glucagon receptor (GCGR), which is located on liver, kidney, intestinal smooth muscle, brain, adipose tissue, heart and p...


    pub_type: 杂志文章


    authors: Jazayeri A,Doré AS,Lamb D,Krishnamurthy H,Southall SM,Baig AH,Bortolato A,Koglin M,Robertson NJ,Errey JC,Andrews SP,Teobald I,Brown AJ,Cooke RM,Weir M,Marshall FH

    更新日期:2016-05-12 00:00:00

  • True paternal care in a multi-male primate society.

    abstract::Although male parental care is rare among mammals, adult males of many cercopithecine primate species provide care for infants and juveniles. This care is often in the form of grooming, carrying, support in agonistic interactions, and protection against infanticide. For these behaviours to be interpreted as true paren...


    pub_type: 杂志文章


    authors: Buchan JC,Alberts SC,Silk JB,Altmann J

    更新日期:2003-09-11 00:00:00

  • Waning buoyancy in the crustal roots of old mountains.

    abstract::When mountains form through the collision of lithospheric plates, uplift of the Earth's surface is accompanied by thickening of the crust, and the buoyancy of these deep crustal roots (relative to the surrounding mantle) is thought to contribute to the support of mountain topography. Once active tectonism ceases, cont...


    pub_type: 杂志文章


    authors: Fischer KM

    更新日期:2002-06-27 00:00:00

  • Fluctuating interaction network and time-varying stability of a natural fish community.

    abstract::Ecological theory suggests that large-scale patterns such as community stability can be influenced by changes in interspecific interactions that arise from the behavioural and/or physiological responses of individual species varying over time. Although this theory has experimental support, evidence from natural ecosys...


    pub_type: 杂志文章


    authors: Ushio M,Hsieh CH,Masuda R,Deyle ER,Ye H,Chang CW,Sugihara G,Kondoh M

    更新日期:2018-02-15 00:00:00

  • Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region.

    abstract::Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two d...


    pub_type: 杂志文章


    authors: Gough NM,Gearing DP,Nicola NA,Baker E,Pritchard M,Callen DF,Sutherland GR

    更新日期:1990-06-21 00:00:00

  • Designing CD4 immunoadhesins for AIDS therapy.

    abstract::A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...


    pub_type: 杂志文章


    authors: Capon DJ,Chamow SM,Mordenti J,Marsters SA,Gregory T,Mitsuya H,Byrn RA,Lucas C,Wurm FM,Groopman JE

    更新日期:1989-02-09 00:00:00

  • Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness.

    abstract::Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular-matrix ligands, transmitting forces and signals necessary for locomotion. Whether cells will migrate or not on a given substratum, and also their speed, depends on several variables related ...


    pub_type: 杂志文章


    authors: Palecek SP,Loftus JC,Ginsberg MH,Lauffenburger DA,Horwitz AF

    更新日期:1997-02-06 00:00:00

  • Structure and elasticity of microtubule-associated protein tau.

    abstract::Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains...


    pub_type: 杂志文章


    authors: Lichtenberg B,Mandelkow EM,Hagestedt T,Mandelkow E

    更新日期:1988-07-28 00:00:00

  • Southern Ocean sea-ice extent, productivity and iron flux over the past eight glacial cycles.

    abstract::Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...


    pub_type: 杂志文章


    authors: Wolff EW,Fischer H,Fundel F,Ruth U,Twarloh B,Littot GC,Mulvaney R,Röthlisberger R,de Angelis M,Boutron CF,Hansson M,Jonsell U,Hutterli MA,Lambert F,Kaufmann P,Stauffer B,Stocker TF,Steffensen JP,Bigler M,Siggaard-An

    更新日期:2006-03-23 00:00:00

  • Diverse polarization angle swings from a repeating fast radio burst source.

    abstract::Fast radio bursts (FRBs) are millisecond-duration radio transients1,2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres3-5 or relativistic shocks far from the central energy source6-8. Detailed polarization observations may help us t...


    pub_type: 杂志文章


    authors: Luo R,Wang BJ,Men YP,Zhang CF,Jiang JC,Xu H,Wang WY,Lee KJ,Han JL,Zhang B,Caballero RN,Chen MZ,Chen XL,Gan HQ,Guo YJ,Hao LF,Huang YX,Jiang P,Li H,Li J,Li ZX,Luo JT,Pan J,Pei X,Qian L,Sun JH,Wang M,Wa

    更新日期:2020-10-01 00:00:00

  • Happy centenary, photon.

    abstract::One hundred years ago Albert Einstein introduced the concept of the photon. Although in the early years after 1905 the evidence for the quantum nature of light was not compelling, modern experiments--especially those using photon pairs--have beautifully confirmed its corpuscular character. Research on the quantum prop...


    pub_type: 杂志文章


    authors: Zeilinger A,Weihs G,Jennewein T,Aspelmeyer M

    更新日期:2005-01-20 00:00:00

  • Ecological opportunity and sexual selection together predict adaptive radiation.

    abstract::A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...


    pub_type: 杂志文章


    authors: Wagner CE,Harmon LJ,Seehausen O

    更新日期:2012-07-19 00:00:00

  • An allosteric mechanism of Rho-dependent transcription termination.

    abstract::Rho is the essential RNA helicase that sets the borders between transcription units and adjusts transcriptional yield to translational needs in bacteria. Although Rho was the first termination factor to be discovered, the actual mechanism by which it reaches and disrupts the elongation complex (EC) is unknown. Here we...


    pub_type: 杂志文章


    authors: Epshtein V,Dutta D,Wade J,Nudler E

    更新日期:2010-01-14 00:00:00

  • Patch repair of deep wounds by mobilized fascia.

    abstract::Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...


    pub_type: 杂志文章


    authors: Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

    更新日期:2019-12-01 00:00:00

  • Survival times of anomalous melt inclusions from element diffusion in olivine and chromite.

    abstract::The chemical composition of basaltic magma erupted at the Earth's surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal assimilation at lower pressures. It has been proposed that studyi...


    pub_type: 杂志文章


    authors: Spandler C,O'Neill HS,Kamenetsky VS

    更新日期:2007-05-17 00:00:00

  • Real and apparent movement nulled.

    abstract::It is a controversial issue whether 'real' movement, seen from the successive stimulation of retinal receptors by a moving image, and 'apparent' (phi) movement, which is produced by stimuli separated in space and time, are transmitted by the same or different neural channels. With this question in mind, we have devise...


    pub_type: 杂志文章


    authors: Gregory RL,Harris JP

    更新日期:1984-02-23 00:00:00

  • How broken sleep promotes cardiovascular disease.

    abstract:: ...


    pub_type: 评论,新闻


    authors: Tall AR,Jelic S

    更新日期:2019-02-01 00:00:00

  • Bell violation using entangled photons without the fair-sampling assumption.

    abstract::The violation of a Bell inequality is an experimental observation that forces the abandonment of a local realistic viewpoint--namely, one in which physical properties are (probabilistically) defined before and independently of measurement, and in which no physical influence can propagate faster than the speed of light...


    pub_type: 杂志文章


    authors: Giustina M,Mech A,Ramelow S,Wittmann B,Kofler J,Beyer J,Lita A,Calkins B,Gerrits T,Nam SW,Ursin R,Zeilinger A

    更新日期:2013-05-09 00:00:00

  • Bacterial carbon processing by generalist species in the coastal ocean.

    abstract::The assimilation and mineralization of dissolved organic carbon (DOC) by marine bacterioplankton is a major process in the ocean carbon cycle. However, little information exists on the specific metabolic functions of participating bacteria and on whether individual taxa specialize on particular components of the marin...


    pub_type: 杂志文章


    authors: Mou X,Sun S,Edwards RA,Hodson RE,Moran MA

    更新日期:2008-02-07 00:00:00

  • Folding at the speed limit.

    abstract::Many small proteins seem to fold by a simple process explicable by conventional chemical kinetics and transition-state theory. This assumes an instant equilibrium between reactants and a high-energy activated state. In reality, equilibration occurs on timescales dependent on the molecules involved, below which such an...


    pub_type: 杂志文章


    authors: Yang WY,Gruebele M

    更新日期:2003-05-08 00:00:00

  • How the olfactory system makes sense of scents.

    abstract::The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...


    pub_type: 杂志文章,评审


    authors: Firestein S

    更新日期:2001-09-13 00:00:00

  • Nanosecond X-ray diffraction of shock-compressed superionic water ice.

    abstract::Since Bridgman's discovery of five solid water (H2O) ice phases1 in 1912, studies on the extraordinary polymorphism of H2O have documented more than seventeen crystalline and several amorphous ice structures2,3, as well as rich metastability and kinetic effects4,5. This unique behaviour is due in part to the geometric...


    pub_type: 杂志文章


    authors: Millot M,Coppari F,Rygg JR,Correa Barrios A,Hamel S,Swift DC,Eggert JH

    更新日期:2019-05-01 00:00:00

  • Mesoscale vertical motion and the size structure of phytoplankton in the ocean.

    abstract::Phytoplankton size structure is acknowledged as a fundamental property determining energy flow through 'microbial' or 'herbivore' pathways. The balance between these two pathways determines the ability of the ecosystem to recycle carbon within the upper layer or to export it to the ocean interior. Small cells are usua...


    pub_type: 杂志文章


    authors: Rodríguez J,Tintoré J,Allen JT,Blanco JM,Gomis D,Reul A,Ruiz J,Rodríguez V,Echevarría F,Jiménez-Gómez F

    更新日期:2001-03-15 00:00:00

  • Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.

    abstract::RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated and RecBCD loads Re...


    pub_type: 杂志文章


    authors: Singleton MR,Dillingham MS,Gaudier M,Kowalczykowski SC,Wigley DB

    更新日期:2004-11-11 00:00:00

  • Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor.

    abstract::Atrial extracts contain factors which induce potent natriuresis changes in renal haemodynamics, and relax pre-contracted vascular smooth muscle. Low-molecular-weight peptides which mimic these actions have now been purified by several groups, including ours (see accompanying paper), and higher-molecular-weight protein...


    pub_type: 杂志文章


    authors: Yamanaka M,Greenberg B,Johnson L,Seilhamer J,Brewer M,Friedemann T,Miller J,Atlas S,Laragh J,Lewicki J

    更新日期:1984-06-21 00:00:00

  • Location-level processes drive the establishment of alien bird populations worldwide.

    abstract::Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...


    pub_type: 杂志文章


    authors: Redding DW,Pigot AL,Dyer EE,Şekercioğlu ÇH,Kark S,Blackburn TM

    更新日期:2019-07-01 00:00:00

  • Resolving the long-standing enigmas of a giant ornithomimosaur Deinocheirus mirificus.

    abstract::The holotype of Deinocheirus mirificus was collected by the 1965 Polish-Mongolian Palaeontological Expedition at Altan Uul III in the southern Gobi of Mongolia. Because the holotype consists mostly of giant forelimbs (2.4 m in length) with scapulocoracoids, for almost 50 years Deinocheirus has remained one of the most...


    pub_type: 杂志文章


    authors: Lee YN,Barsbold R,Currie PJ,Kobayashi Y,Lee HJ,Godefroit P,Escuillié F,Chinzorig T

    更新日期:2014-11-13 00:00:00

  • Double-walled polymer microspheres for controlled drug release.

    abstract::One approach to the controlled release of drugs involves incorporation of the drug molecules into the matrix of microscopic polymer spheres or capsules. Existing methods for preparing such microparticles do not, however, always guarantee a constant release rate, for example because drug molecules may be trapped prefer...


    pub_type: 杂志文章


    authors: Pekarek KJ,Jacob JS,Mathiowitz E

    更新日期:1994-01-20 00:00:00

  • Prodigious degassing of a billion years of accumulated radiogenic helium at Yellowstone.

    abstract::Helium is used as a critical tracer throughout the Earth sciences, where its relatively simple isotopic systematics is used to trace degassing from the mantle, to date groundwater and to time the rise of continents. The hydrothermal system at Yellowstone National Park is famous for its high helium-3/helium-4 isotope r...


    pub_type: 杂志文章


    authors: Lowenstern JB,Evans WC,Bergfeld D,Hunt AG

    更新日期:2014-02-20 00:00:00

  • Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.

    abstract::Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...


    pub_type: 杂志文章


    authors: Gubler U,Seeburg P,Hoffman BJ,Gage LP,Udenfriend S

    更新日期:1982-01-21 00:00:00