Abstract:
:In Drosophila, Decapentaplegic (Dpp) and Wingless (Wg) are two secreted signalling proteins of the transforming growth factor (TGF)-beta and Wnt families, respectively. Although both are often required during development, only a few downstream components of these signalling pathways have been described. Here we present evidence that in the embryonic midgut both signalling pathways control the subcellular localization of the homeodomain protein encoded by the extradenticle (exd) gene. Exd protein is predominantly nuclear in endoderm cells close to Dpp-and Wg-secreting cells of the visceral mesoderm, but is in the cytoplasm in more distant endoderm cells. Both dpp and wg are required for the nuclear localization of Exd in the endoderm, whereas ectopic expression of dpp and wg expands the domain of nuclear Exd. Furthermore, the nuclear import of Exd correlates with the transcription of an exd-dependent reporter gene in the endoderm. Thus one mechanism by which extracellular signals might control pattern is by directing the graded nuclear localization of homeodomain proteins such as Exd that directly control the expression of target genes.
journal_name
Naturejournal_title
Natureauthors
Mann RS,Abu-Shaar Mdoi
10.1038/383630a0subject
Has Abstractpub_date
1996-10-17 00:00:00pages
630-3issue
6601eissn
0028-0836issn
1476-4687journal_volume
383pub_type
杂志文章相关文献
NATURE文献大全abstract::Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/287681a0
更新日期:1980-10-23 00:00:00
abstract::Prized for their ability to rapidly generate chemical complexity by building new ring systems and stereocentres1, cycloaddition reactions have featured in numerous total syntheses2 and are a key component in the education of chemistry students3. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to syn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0391-9
更新日期:2018-08-01 00:00:00
abstract::Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23738
更新日期:1999-08-26 00:00:00
abstract::Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numero...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08143
更新日期:2009-05-21 00:00:00
abstract::Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08851
更新日期:2010-04-08 00:00:00
abstract::The onsert of neuronal differentiation is characterised by intensive neurite growth; because microtubule formation is strictly required during this process, in vitro assembly of the tubulin present in the rat brain has been studied at different stages of development: the rate of assembly is very slow in the early stag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284353a0
更新日期:1980-03-27 00:00:00
abstract::Fungi are the principal degraders of biomass in terrestrial ecosystems and establish important interactions with plants and animals. However, our current understanding of fungal evolutionary diversity is incomplete and is based upon species amenable to growth in culture. These culturable fungi are typically yeast or f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09984
更新日期:2011-05-11 00:00:00
abstract::Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09089
更新日期:2010-06-24 00:00:00
abstract::We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K+ ('M') channels, in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305148a0
更新日期:1983-09-08 00:00:00
abstract::Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347192a0
更新日期:1990-09-13 00:00:00
abstract::It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341154a0
更新日期:1989-09-14 00:00:00
abstract::Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370128a0
更新日期:1994-07-14 00:00:00
abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08005
更新日期:2009-05-28 00:00:00
abstract::Cognitive ethology focuses on the study of animals under natural conditions to reveal ecologically adapted modes of learning. But biologists can more easily study what an animal learns than how it learns. For example, honeybees take repeated 'orientation' flights before becoming foragers at about three weeks of age. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35000564
更新日期:2000-02-03 00:00:00
abstract::The surfaces of Earth and Mars contain large bedrock canyons that were carved by catastrophic outburst floods. Reconstructing the magnitude of these canyon-forming floods is essential for understanding the ways in which floods modify planetary surfaces, the hydrology of early Mars and abrupt changes in climate. Flood ...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature19817
更新日期:2016-10-13 00:00:00
abstract::The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09423
更新日期:2010-10-14 00:00:00
abstract::As oligodendrocytes wrap axons of the central nervous system (CNS) with insulating myelin sheaths, sodium channels that are initially continuously distributed along axons become segregated into regularly spaced gaps in the myelin called nodes of Ranvier. It is not known whether the regular spacing of nodes results fro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386724a0
更新日期:1997-04-17 00:00:00
abstract::The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355841a0
更新日期:1992-02-27 00:00:00
abstract::Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/349293a0
更新日期:1991-01-24 00:00:00
abstract::Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1382-1
更新日期:2019-07-01 00:00:00
abstract::In this Letter, the top structure of the right panel of Fig. 1a should be that of cis-9-octadecenoic acid, not trans-9-octadecenoic acid. Please see the accompanying Author Correction. This error has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-0930-z
更新日期:2019-03-01 00:00:00
abstract::One hundred years ago Albert Einstein introduced the concept of the photon. Although in the early years after 1905 the evidence for the quantum nature of light was not compelling, modern experiments--especially those using photon pairs--have beautifully confirmed its corpuscular character. Research on the quantum prop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03280
更新日期:2005-01-20 00:00:00
abstract::Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/311678a0
更新日期:1984-10-18 00:00:00
abstract::Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11661
更新日期:2013-01-10 00:00:00
abstract::The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/36038
更新日期:1998-02-26 00:00:00
abstract::Mice express a collection of superantigens, which bind to class II major histocompatibility proteins and interact with T cells bearing particular V beta chains as part of their alpha beta receptors. These superantigens have been suggested to be encoded by exogenous or endogenous mouse mammary tumour viruses. One such ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350203a0
更新日期:1991-03-21 00:00:00
abstract::The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12180
更新日期:2013-06-06 00:00:00
abstract::The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13324
更新日期:2014-05-22 00:00:00
abstract::The mineral olivine dominates the composition of the Earth's upper mantle and hence controls its mechanical behaviour and seismic anisotropy. Experiments at high temperature and moderate pressure, and extensive data on naturally deformed mantle rocks, have led to the conclusion that olivine at upper-mantle conditions ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03266
更新日期:2005-02-17 00:00:00
abstract::Aberrant neovascularization contributes to diseases such as cancer, blindness and atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although many regulators of pathogenic angiogenesis have been identified, our understanding of this process is incomplete. Here we explore the transcriptome ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12345
更新日期:2013-07-18 00:00:00