Abstract：
:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral nerve cord. In unc-4(e120), the presynaptic partners of VA motor neurons are replaced with interneurons appropriate to motor neurons of the VB class. This change in neural specificity is not accompanied by any detectable effects on neuronal morphology or process extension. We show that the absence of a functional unc-4 gene product accounts for the mutant phenotype. The unc-4 gene encodes a homeodomain protein and thus is likely to function as a transcription factor. The limited effect of the unc-4 null mutation on cell fate may mean that unc-4 regulates the expression of a small number of target genes and that the products of these genes are directly involved in the choice of synaptic partners.
journal_name
Naturejournal_title
Natureauthors
Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson Ldoi
10.1038/355841a0keywords:
subject
Has Abstractpub_date
1992-02-27 00:00:00pages
841-5issue
6363eissn
0028-0836issn
1476-4687journal_volume
355pub_type
杂志文章相关文献
NATURE文献大全abstract：:The T-cell immune response is directed against antigenic peptide fragments generated in intracellular compartments, the cytosol or the endocytic system. Peptides derived from cytosolic proteins, usually of biosynthetic origin, are presented efficiently to T-cell receptors by major histocompatibility complex (MHC) clas...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/348738a0
更新日期：1990-12-20 00:00:00
abstract：:Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11585
更新日期：2012-11-01 00:00:00
abstract：:All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/350247a0
更新日期：1991-03-21 00:00:00
abstract：:During cell division, chromosomes are segregated to nascent daughter cells by attaching to the microtubules of the mitotic spindle through the kinetochore. Kinetochores are assembled on a specialized chromatin domain called the centromere, which is characterized by the replacement of nucleosomal histone H3 with the hi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10379
更新日期：2011-08-28 00:00:00
abstract：:Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet when measured mi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13237
更新日期：2014-05-08 00:00:00
abstract：:Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08581
更新日期：2009-11-26 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/365253a0
更新日期：1993-09-16 00:00:00
abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/379177a0
更新日期：1996-01-11 00:00:00
abstract：:The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature19079
更新日期：2016-08-11 00:00:00
abstract：:Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02711
更新日期：2004-08-05 00:00:00
abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35078077
更新日期：2001-05-24 00:00:00
abstract：:The major excitatory amino acids, glutamate (Glu) and aspartate (Asp), are thought to act at three receptor subtypes in the mammalian central nervous system (CNS). These are termed quisqualate (QA), N-methyl-D-aspartate (NMDA) and kainate (KA) receptors according to the specific agonist properties of these compounds r...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/317717a0
更新日期：1985-10-24 00:00:00
abstract：:The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcriptio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/371796a0
更新日期：1994-10-27 00:00:00
abstract：:In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding aden...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25174
更新日期：2018-01-18 00:00:00
abstract：:In the cores of some clusters of galaxies the hot intracluster plasma is dense enough that it should cool radiatively in the cluster's lifetime, leading to continuous 'cooling flows' of gas sinking towards the cluster centre, yet no such cooling flow has been observed. The low observed star-formation rates and cool ga...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11379
更新日期：2012-08-16 00:00:00
abstract：:It has been suggested that the initiation step in mouse skin carcinogenesis involves an alteration in epidermal-differentiation, as mouse basal keratinocytes exposed to initiators resist the arrest of cell growth that is normally associated with the induction of terminal differentiation by calcium ions. The growth of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/314459a0
更新日期：1985-04-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature
pub_type： 已发布勘误
doi：10.1038/s41586-020-2581-5
更新日期：2020-08-01 00:00:00
abstract：:Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in re...
journal_title：Nature
pub_type： 临床试验,杂志文章
doi：10.1038/nature03985
更新日期：2005-10-13 00:00:00
abstract：:An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/301432a0
更新日期：1983-02-03 00:00:00
abstract：:Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12504
更新日期：2013-09-05 00:00:00
abstract：:Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives of rubella viru...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2812-9
更新日期：2020-10-01 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/d41586-019-00737-2
更新日期：2019-03-01 00:00:00
abstract：:Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/416878a
更新日期：2002-04-25 00:00:00
abstract：:Most Oryza sativa cultivars die within a week of complete submergence--a major constraint to rice production in south and southeast Asia that causes annual losses of over US 1 billion dollars and affects disproportionately the poorest farmers in the world. A few cultivars, such as the O. sativa ssp. indica cultivar FR...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04920
更新日期：2006-08-10 00:00:00
abstract：:Self-propagating beta-sheet-rich protein aggregates are implicated in a wide range of protein-misfolding phenomena, including amyloid diseases and prion-based inheritance. Two properties have emerged as common features of amyloids. Amyloid formation is ubiquitous: many unrelated proteins form such aggregates and even ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01894
更新日期：2003-08-21 00:00:00
abstract：:The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature01400
更新日期：2003-01-23 00:00:00
abstract：:A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35059138
更新日期：2001-02-22 00:00:00
abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07385
更新日期：2008-10-23 00:00:00
abstract：:Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragme...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35172
更新日期：1998-01-29 00:00:00
abstract：:The ability to confine and store optical energy in small volumes has implications in fields ranging from cavity quantum electrodynamics to photonics. Of all cavity geometries, micrometre-sized dielectric spherical resonators are the best in terms of their ability to store energy for long periods of time within small v...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415621a
更新日期：2002-02-07 00:00:00
