Man-made antibodies.

abstract：:Using a recently developed formalism called topological quantum chemistry, we perform a high-throughput search of 'high-quality' materials (for which the atomic positions and structure have been measured very accurately) in the Inorganic Crystal Structure Database in order to identify new topological phases. We develo...

journal_title：Nature

authors： Vergniory MG,Elcoro L,Felser C,Regnault N,Bernevig BA,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper fun...

journal_title：Nature

authors： Liu Y,Hong X,Kappler J,Jiang L,Zhang R,Xu L,Pan CH,Martin WE,Murphy RC,Shu HB,Dai S,Zhang G

更新日期：2003-05-01 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:Neurons develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures. Among MAPs, MAP2 is specifically expressed in dendrites whereas MAP2C and tau are abundant in the axon. But the...

journal_title：Nature

authors： Chen J,Kanai Y,Cowan NJ,Hirokawa N

更新日期：1992-12-17 00:00:00

abstract：:Black holes become visible when they accrete gas, a common source of which is a close stellar companion. The standard theory for this process (invoking a 'thin accretion disk') does not explain some spectacular phenomena associated with these systems, such as their X-ray variability and relativistic outflows, indicati...

journal_title：Nature

authors： Kanbach G,Straubmeier C,Spruit HC,Belloni T

更新日期：2001-11-08 00:00:00

abstract：:Protein engineering is being developed for mapping the energetics and pathway of protein folding. From kinetic studies on wild-type and mutant proteins, the sequence and energetics of formation of tertiary interactions of side chains can be mapped and the formation of secondary structure inferred. Here we cross-check ...

journal_title：Nature

authors： Bycroft M,Matouschek A,Kellis JT Jr,Serrano L,Fersht AR

更新日期：1990-08-02 00:00:00

abstract：:Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...

journal_title：Nature

authors： Jonsson P,Bandlamudi C,Cheng ML,Srinivasan P,Chavan SS,Friedman ND,Rosen EY,Richards AL,Bouvier N,Selcuklu SD,Bielski CM,Abida W,Mandelker D,Birsoy O,Zhang L,Zehir A,Donoghue MTA,Baselga J,Offit K,Scher HI,O'Reill

更新日期：2019-07-01 00:00:00

abstract：:T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively. However, peripheral T-cell deletion takes place in...

journal_title：Nature

authors： Zheng L,Fisher G,Miller RE,Peschon J,Lynch DH,Lenardo MJ

更新日期：1995-09-28 00:00:00

abstract：:Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an alpha subunit and one of two beta subunits (beta A or beta B). FSH-releasing protein (FRP), al...

journal_title：Nature

authors： Yu J,Shao LE,Lemas V,Yu AL,Vaughan J,Rivier J,Vale W

更新日期：1987-12-24 00:00:00

abstract：:Positron emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decrease...

journal_title：Nature

authors： Drevets WC,Burton H,Videen TO,Snyder AZ,Simpson JR Jr,Raichle ME

更新日期：1995-01-19 00:00:00

abstract：:Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses. Human immunodeficiency virus 1 (HIV-1) fails to transduce dendritic cells and has a reduced ability to tra...

journal_title：Nature

authors： Hrecka K,Hao C,Gierszewska M,Swanson SK,Kesik-Brodacka M,Srivastava S,Florens L,Washburn MP,Skowronski J

更新日期：2011-06-29 00:00:00

abstract：:In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...

journal_title：Nature

authors： Schäfer BW,Blakely BT,Darlington GJ,Blau HM

更新日期：1990-03-29 00:00:00

abstract：:The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01 degrees and 0.92 degrees , respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these satellites (see ref. ...

journal_title：Nature

authors： Bell JF 3rd,Lemmon MT,Duxbury TC,Hubbard MY,Wolff MJ,Squyres SW,Craig L,Ludwinski JM

更新日期：2005-07-07 00:00:00

abstract：:Comparisons of three-dimensional maps of vertebrate muscle thin filaments obtained by cryo-electron microscopy and image analysis, reveal the molecular structure of F-actin, the location of the C terminus of the monomer and the positions of the binding sites of tropomyosin, the myosin head and the N-terminal portion o...

journal_title：Nature

authors： Milligan RA,Whittaker M,Safer D

更新日期：1990-11-15 00:00:00

abstract：: ...

journal_title：Nature

authors： Hershkovitz I

更新日期：2019-02-01 00:00:00

abstract：:It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of acti...

journal_title：Nature

authors： Koob GF,Dantzer R,Rodriguez F,Bloom FE,Le Moal M

更新日期：1985-06-27 00:00:00

abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

journal_title：Nature

authors： Burgisser A,Bergantz GW

更新日期：2011-03-10 00:00:00

abstract：:Folding of two monomeric enzymes mediated by groE has been reconstituted in vitro. The groEL protein stabilizes the polypeptides in a conformation resembling the 'molten globule' state. Mg-ATP and groES then promote the acquisition of ordered tertiary structure at the surface of groEL. Folding requires the hydrolysis ...

journal_title：Nature

authors： Martin J,Langer T,Boteva R,Schramel A,Horwich AL,Hartl FU

更新日期：1991-07-04 00:00:00

abstract：:The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...

journal_title：Nature

authors： Ciais P,Tan J,Wang X,Roedenbeck C,Chevallier F,Piao SL,Moriarty R,Broquet G,Le Quéré C,Canadell JG,Peng S,Poulter B,Liu Z,Tans P

更新日期：2019-04-01 00:00:00

abstract：:In this Letter, the statement 'I.I. and A.B. performed computations at the NCI Australia' was missing from the Acknowledgements section. This has been corrected online. ...

journal_title：Nature

authors： Sainadh US,Xu H,Wang X,Atia-Tul-Noor A,Wallace WC,Douguet N,Bray A,Ivanov I,Bartschat K,Kheifets A,Sang RT,Litvinyuk IV

更新日期：2019-05-01 00:00:00

abstract：:Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population. Despite the frequency, neither the mechanisms of valve calcification nor the developmental origin of a tw...

journal_title：Nature

authors： Garg V,Muth AN,Ransom JF,Schluterman MK,Barnes R,King IN,Grossfeld PD,Srivastava D

更新日期：2005-09-08 00:00:00

abstract：:Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult p...

journal_title：Nature

authors： Yamada M,Miyakawa T,Duttaroy A,Yamanaka A,Moriguchi T,Makita R,Ogawa M,Chou CJ,Xia B,Crawley JN,Felder CC,Deng CX,Wess J

更新日期：2001-03-08 00:00:00

abstract：:When electrons are subject to a large external magnetic field, the conventional charge quantum Hall effect dictates that an electronic excitation gap is generated in the sample bulk, but metallic conduction is permitted at the boundary. Recent theoretical models suggest that certain bulk insulators with large spin-orb...

journal_title：Nature

authors： Hsieh D,Qian D,Wray L,Xia Y,Hor YS,Cava RJ,Hasan MZ

更新日期：2008-04-24 00:00:00

abstract：:X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis f...

journal_title：Nature

authors： Brown CJ,Lafreniere RG,Powers VE,Sebastio G,Ballabio A,Pettigrew AL,Ledbetter DH,Levy E,Craig IW,Willard HF

更新日期：1991-01-03 00:00:00

abstract：:Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist ...

journal_title：Nature

authors： Beura LK,Hamilton SE,Bi K,Schenkel JM,Odumade OA,Casey KA,Thompson EA,Fraser KA,Rosato PC,Filali-Mouhim A,Sekaly RP,Jenkins MK,Vezys V,Haining WN,Jameson SC,Masopust D

更新日期：2016-04-28 00:00:00

abstract：:The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...

journal_title：Nature

authors： Chia W,McGill S,Karp R,Gubb D,Ashburner M

更新日期：1985-07-04 00:00:00

abstract：:Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...

journal_title：Nature

authors： Zipfel C,Oldroyd GE

更新日期：2017-03-15 00:00:00

abstract：:Structural fluctuations in proteins on the picosecond timescale have been studied in considerable detail by theoretical methods such as molecular dynamics simulation, but there exist very few experimental data with which to test the conclusions. We have used the technique of inelastic neutron scattering to investigate...

journal_title：Nature

authors： Doster W,Cusack S,Petry W

更新日期：1989-02-23 00:00:00

abstract：:NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To ou...

journal_title：Nature

authors： Steuber J,Vohl G,Casutt MS,Vorburger T,Diederichs K,Fritz G

更新日期：2014-12-04 00:00:00

abstract：:Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one ...

journal_title：Nature

authors： Saeed M,Andreo U,Chung HY,Espiritu C,Branch AD,Silva JM,Rice CM

更新日期：2015-08-27 00:00:00