Abstract:
:Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?
journal_name
Naturejournal_title
Natureauthors
Winter G,Milstein Cdoi
10.1038/349293a0subject
Has Abstractpub_date
1991-01-24 00:00:00pages
293-9issue
6307eissn
0028-0836issn
1476-4687journal_volume
349pub_type
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