Crystal structure of nucleotide-free dynamin.

abstract：:Metallothioneins are small cysteine-rich proteins that bind heavy metals such as zinc, cadmium, copper and mercury. Recent interest in these proteins has focused on the part they play in zinc metabolism and heavy metal detoxification. Our interest in metallothionein genes stems largely from the observations that these...

journal_title：Nature

authors： Glanville N,Durnam DM,Palmiter RD

更新日期：1981-07-16 00:00:00

abstract：:The first open meeting to discuss the growing issue of commercialism in academic research was convened by the New York Bar Association's patent committee. Participants included Steven Muller, president of Johns Hopkins University, Joshua Lederberg, president of Rockefeller University, and A. Thomas Bartlett, presiden...

journal_title：Nature

authors： Stein MD

更新日期：1982-04-29 00:00:00

abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

journal_title：Nature

authors： Noel JP,Hamm HE,Sigler PB

更新日期：1993-12-16 00:00:00

abstract：:Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples fro...

journal_title：Nature

authors： International HapMap Consortium.

更新日期：2005-10-27 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...

journal_title：Nature

authors： Allen H,Wraith D,Pala P,Askonas B,Flavell RA

更新日期：1984-05-17 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein's fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic ...

journal_title：Nature

authors： Bershtein S,Segal M,Bekerman R,Tokuriki N,Tawfik DS

更新日期：2006-12-14 00:00:00

abstract：:Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The 'Phillips' mechanism is widely held as the paradig...

journal_title：Nature

authors： Vocadlo DJ,Davies GJ,Laine R,Withers SG

更新日期：2001-08-23 00:00:00

abstract：:The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...

journal_title：Nature

authors： Peeper DS,Upton TM,Ladha MH,Neuman E,Zalvide J,Bernards R,DeCaprio JA,Ewen ME

更新日期：1997-03-13 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...

journal_title：Nature

authors： Gack MU,Shin YC,Joo CH,Urano T,Liang C,Sun L,Takeuchi O,Akira S,Chen Z,Inoue S,Jung JU

更新日期：2007-04-19 00:00:00

abstract：:The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

journal_title：Nature

authors： Manne AS,Richels RG

更新日期：2001-04-05 00:00:00

abstract：:In the present-day climate, surface water salinities are low in the western tropical Pacific Ocean and increase towards the eastern part of the basin. The salinity of surface waters in the tropical Pacific Ocean is thought to be controlled by a combination of atmospheric convection, precipitation, evaporation and ocea...

journal_title：Nature

authors： Stott L,Cannariato K,Thunell R,Haug GH,Koutavas A,Lund S

更新日期：2004-09-02 00:00:00

abstract：:Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...

journal_title：Nature

authors： Svoboda K,Schmidt CF,Schnapp BJ,Block SM

更新日期：1993-10-21 00:00:00

abstract：:The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinte...

journal_title：Nature

authors： Wang ZQ,Fung MR,Barlow DP,Wagner EF

更新日期：1994-12-01 00:00:00

abstract：:The dwarfing of large mammals on islands occurred repeatedly in the Pleistocene. Elephants, deer, hippopotami and other species became dwarfed on islands in Indonesia, the Mediterranean, the east Pacific and elsewhere. In most cases, the full-sized ancestral form can be recognized among the adjacent mainland fauna, bu...

journal_title：Nature

authors： Lister AM

更新日期：1989-11-30 00:00:00

abstract：:Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...

journal_title：Nature

authors： Wilson AC,Colombe Y,Brown KR,Knill E,Leibfried D,Wineland DJ

更新日期：2014-08-07 00:00:00

abstract：:A key event in the domestication and breeding of the oil palm Elaeis guineensis was loss of the thick coconut-like shell surrounding the kernel. Modern E. guineensis has three fruit forms, dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), a hybrid between dura and pisifera. The pisifera palm is us...

journal_title：Nature

authors： Singh R,Low ET,Ooi LC,Ong-Abdullah M,Ting NC,Nagappan J,Nookiah R,Amiruddin MD,Rosli R,Manaf MA,Chan KL,Halim MA,Azizi N,Lakey N,Smith SW,Budiman MA,Hogan M,Bacher B,Van Brunt A,Wang C,Ordway JM,Sambanthamurthi

更新日期：2013-08-15 00:00:00

abstract：:Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...

journal_title：Nature

authors： Foreman BZ,Heller PL,Clementz MT

更新日期：2012-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a member of the herpes group of viruses and the aetiological agent of infectious mononucleosis, is usually thought of as a lymphotrophic virus with the ability to transform B lymphocytes. So the association of EBV with nasopharyngeal carcinoma is puzzling, especially given the lack of success...

journal_title：Nature

authors： Sixbey JW,Vesterinen EH,Nedrud JG,Raab-Traub N,Walton LA,Pagano JS

更新日期：1983-12-01 00:00:00

abstract：:A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...

journal_title：Nature

authors： David P

更新日期：1983-09-15 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...

journal_title：Nature

authors： Mann ME,Woodruff JD,Donnelly JP,Zhang Z

更新日期：2009-08-13 00:00:00

abstract：:Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influe...

journal_title：Nature

authors： Wen L,Ley RE,Volchkov PY,Stranges PB,Avanesyan L,Stonebraker AC,Hu C,Wong FS,Szot GL,Bluestone JA,Gordon JI,Chervonsky AV

更新日期：2008-10-23 00:00:00

abstract：:Methyl chloride is the largest natural source of ozone-depleting chlorine compounds, and accounts for about 15 per cent of the present atmospheric chlorine content. This contribution was likely to have been relatively greater in pre-industrial times, when additional anthropogenic sources-such as chlorofluorocarbons-we...

journal_title：Nature

authors： Yokouchi Y,Ikeda M,Inuzuka Y,Yukawa T

更新日期：2002-03-14 00:00:00

abstract：:Werner's syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common. The WS mutation has pleiotropic effects, a...

journal_title：Nature

authors： Goto M,Rubenstein M,Weber J,Woods K,Drayna D

更新日期：1992-02-20 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...

journal_title：Nature

authors： Anacker C,Luna VM,Stevens GS,Millette A,Shores R,Jimenez JC,Chen B,Hen R

更新日期：2018-07-01 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00