Abstract：
:The HLA-D region of the human major histocompatibility complex (MHC) has been shown to be homologous to the murine I region in terms of both structure and function. Both regions encode class II MHC molecules which restrict T-lymphocyte interactions with antigen-presenting cells. We have recently described the MHC restriction and antigen specificities of human T-lymphocyte clones directed at strain A influenza virus. The majority of T-lymphocyte clones recognized antigen in the context of cell surface interaction products encoded by HLA-D/DR genes. However, a few clones recognized antigen presented by cells histoincompatible for D/DR antigens. We report here that some of these clones recognized viral antigens in association with antigens encoded by genes identical with or closely linked to the recently described secondary B-cell (SB) locus of the MHC. This is the first report that SB-restricted antigen recognition may form an integral part of normal, human immune responses.
journal_name
Naturejournal_title
Natureauthors
Eckels DD,Lake P,Lamb JR,Johnson AH,Shaw S,Woody JN,Hartzman RJdoi
10.1038/301716a0subject
Has Abstractpub_date
1983-02-24 00:00:00pages
716-8issue
5902eissn
0028-0836issn
1476-4687journal_volume
301pub_type
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