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NATURE文献大全abstract::Transcriptional silencing of the HM mating-type loci in the yeast Saccharomyces cerevisiae is caused by the localized formation of an altered chromatin structure, analogous to heterochromatin in higher eukaryotes. Silencing depends on cis-acting sequences, termed silencers, as well as several trans-acting factors, inc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381251a0
更新日期:1996-05-16 00:00:00
abstract::The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19079
更新日期:2016-08-11 00:00:00
abstract::Synaptic transmission of most vertebrate synapses is thought to be terminated by rapid transport of the neurotransmitter into presynaptic nerve terminals or neuroglia. L-Glutamate is the major excitatory transmitter in brain and its transport represents the mechanism by which it is removed from the synaptic cleft and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360464a0
更新日期:1992-12-03 00:00:00
abstract::A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/276033a0
更新日期:1978-11-02 00:00:00
abstract::Compartments in food webs are subgroups of taxa in which many strong interactions occur within the subgroups and few weak interactions occur between the subgroups. Theoretically, compartments increase the stability in networks, such as food webs. Compartments have been difficult to detect in empirical food webs becaus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02115
更新日期:2003-11-20 00:00:00
abstract::Transcription initiation factor TFIID is a multisubunit complex containing a TATA-box-binding factor (TFIID tau/TBP) and associated polypeptide factors (TAFs) with sizes ranging from M(r) approximately 20,000 to > 200,000. As a result of direct promoter interactions, TFIID nucleates the assembly of RNA polymerase II a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367484a0
更新日期:1994-02-03 00:00:00
abstract::Oxygen consumption by carnivorous reptiles increases enormously after they have eaten a large meal in order to meet metabolic demands, and this places an extra load on the cardiovascular system. Here we show that there is an extraordinarily rapid 40% increase in ventricular muscle mass in Burmese pythons (Python molur...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/434037a
更新日期:2005-03-03 00:00:00
abstract::Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363179a0
更新日期:1993-05-13 00:00:00
abstract::Online hate and extremist narratives have been linked to abhorrent real-world events, including a current surge in hate crimes1-6 and an alarming increase in youth suicides that result from social media vitriol7; inciting mass shootings such as the 2019 attack in Christchurch, stabbings and bombings8-11; recruitment o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1494-7
更新日期:2019-09-01 00:00:00
abstract::The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321785a0
更新日期:1986-06-19 00:00:00
abstract::Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases. This response property has led to a hypothesis that dopamine neurons encode value-related signals and are inhibited by aversive events. Here we show that this is tr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08028
更新日期:2009-06-11 00:00:00
abstract::The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353353a0
更新日期:1991-09-26 00:00:00
abstract::On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1936-2
更新日期:2020-02-01 00:00:00
abstract::Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24050
更新日期:2017-10-19 00:00:00
abstract::The benzodiazepines are a class of drugs used to alleviate anxiety. As such they constitute one of the most commonly prescribed compounds, due in part to their efficacy and safety. The physiological effect of these drugs is probably through interactions with a low affinity benzodiazepine binding site and two (types 1 ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/302431a0
更新日期:1983-03-31 00:00:00
abstract::Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11970
更新日期:2013-03-28 00:00:00
abstract::Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05329
更新日期:2006-11-23 00:00:00
abstract::Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09217
更新日期:2010-08-12 00:00:00
abstract::Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05573
更新日期:2007-03-01 00:00:00
abstract::The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04868
更新日期:2006-07-06 00:00:00
abstract::Successful expression of genes transferred into distantly related species in which genetic functions have been maintained through evolution has been reported previously. In the case of the silkmoth Bombyx mori and the fruitfly Drosophila melanogaster, both of which produce chorions (eggshells), Bombyx chorion genes ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346480a0
更新日期:1990-08-02 00:00:00
abstract::Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/372333a0
更新日期:1994-11-24 00:00:00
abstract::The discovery of intervening sequences (introns) in DNA led Gilbert and Tonegawa to suggest that a new protein could have been produced by bringing together certain segments of pre-existing ones. However, Blake argued that if DNA was so organized that coding sequences (exons) correspond to structural as well as functi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/291090a0
更新日期:1981-05-07 00:00:00
abstract::The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding of the aetiologies of complex diseases and may also facilitate the development of novel therapeutic interventions. We have generated iPSCs from patients with L...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09005
更新日期:2010-06-10 00:00:00
abstract::Recent work demonstrates that stochastic fluctuations in molecular populations have consequences for gene regulation. Previous experiments focused on noise sources or noise propagation through gene networks by measuring noise magnitudes. However, in theoretical analysis, we showed that noise frequency content is deter...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04194
更新日期:2006-02-02 00:00:00
abstract::Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mas...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13773
更新日期:2014-10-16 00:00:00
abstract::A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355409a0
更新日期:1992-01-30 00:00:00
abstract::Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350634a0
更新日期:1991-04-18 00:00:00
abstract::The appendage primordia of Drosophila are subdivided into compartments by the localized expression of transcription factors. Interaction between cells in adjacent compartments establishes organizing centres responsible for generating spatial pattern and promoting cell proliferation in the developing appendages. Locali...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372175a0
更新日期:1994-11-10 00:00:00
abstract::Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells. One exception is the unique situation whereby anti-hapten antisera inhibi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308547a0
更新日期:1984-04-05 00:00:00