Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.

Abstract:

:Transcriptional silencing of the HM mating-type loci in the yeast Saccharomyces cerevisiae is caused by the localized formation of an altered chromatin structure, analogous to heterochromatin in higher eukaryotes. Silencing depends on cis-acting sequences, termed silencers, as well as several trans-acting factors, including histones H4 and H3, proteins RAP1 and ABF1, and the four SIR proteins (SIR1-4). Each of the four HM silencers contains an autonomously replicating sequence (ARS) to which the origin replication complex (ORC) binds. This six-protein complex is required for initiation of DNA replication, as well as for silencing. Efficient establishment of the silenced state requires both passage through the S phase of the cell cycle and SIR1 protein. Previous experiments suggested that SIR1 might be localized to the silencers by binding to ORC and/or RAP1. Here we report that SIR1 can bind directly to ORC1, the largest of the ORC subunits, and that targeting of SIR1 to ORC1 at a silencer is sufficient to establish a silenced state.

journal_name

Nature

journal_title

Nature

authors

Triolo T,Sternglanz R

doi

10.1038/381251a0

subject

Has Abstract

pub_date

1996-05-16 00:00:00

pages

251-3

issue

6579

eissn

0028-0836

issn

1476-4687

journal_volume

381

pub_type

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