Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.

abstract：:In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a non-nucleotide antago...

journal_title：Nature

authors： Zhang D,Gao ZG,Zhang K,Kiselev E,Crane S,Wang J,Paoletta S,Yi C,Ma L,Zhang W,Han GW,Liu H,Cherezov V,Katritch V,Jiang H,Stevens RC,Jacobson KA,Zhao Q,Wu B

更新日期：2015-04-16 00:00:00

abstract：:A characteristic feature of induced pinocytosis in Amoeba proteus is the formation of broad channels by invagination of the cell membrane. This process, which requires Ca2+, occurs in response to depolarising cations. High Ca2+ levels reduce pinocytosis induced by cations such as Na+ and Tris+, whereas pinocytosis ind...

journal_title：Nature

authors： Josefsson JO,Johansson P

更新日期：1979-11-01 00:00:00

abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

journal_title：Nature

authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

更新日期：2015-02-26 00:00:00

abstract：:A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantum memories over long distances. Despite enormous progress3-12, at present the maximal physical separation a...

journal_title：Nature

authors： Yu Y,Ma F,Luo XY,Jing B,Sun PF,Fang RZ,Yang CW,Liu H,Zheng MY,Xie XP,Zhang WJ,You LX,Wang Z,Chen TY,Zhang Q,Bao XH,Pan JW

更新日期：2020-02-01 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...

journal_title：Nature

authors： Vogel AB,Kanevsky I,Che Y,Swanson KA,Muik A,Vormehr M,Kranz LM,Walzer KC,Hein S,Güler A,Loschko J,Maddur MS,Ota-Setlik A,Tompkins K,Cole J,Lui BG,Ziegenhals T,Plaschke A,Eisel D,Dany SC,Fesser S,Erbar S,Bates

更新日期：2021-02-01 00:00:00

abstract：:Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new life forms and functions, and the most general route to this goal is th...

journal_title：Nature

authors： Zhang Y,Ptacin JL,Fischer EC,Aerni HR,Caffaro CE,San Jose K,Feldman AW,Turner CR,Romesberg FE

更新日期：2017-11-29 00:00:00

abstract：:The direct involvement of the pituitary-adrenal axis in birth has been well established, at least in sheep, and its removal prolongs pregnancy. As part of the process the fetal sheep adrenal grows rapidly during the 10-15 d prepartum and is associated with a large rise in the plasma corticosteroid concentration. This ...

journal_title：Nature

authors： Roebuck MM,Jones CT,Holland D,Silman R

更新日期：1980-04-17 00:00:00

abstract：:Treatments that target immune checkpoints, such as the one mediated by programmed cell death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human cancers with durable clinical benefit. However, many patients with cancer fail to respond to compounds that target the PD-1 and PD-L1 interaction, an...

journal_title：Nature

authors： Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W

更新日期：2018-01-04 00:00:00

abstract：:B lymphocytes re-circulate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells. Despite the importance of B--T-cell interactions for the induction of antibody re...

journal_title：Nature

authors： Reif K,Ekland EH,Ohl L,Nakano H,Lipp M,Förster R,Cyster JG

更新日期：2002-03-07 00:00:00

abstract：:The holotype of Deinocheirus mirificus was collected by the 1965 Polish-Mongolian Palaeontological Expedition at Altan Uul III in the southern Gobi of Mongolia. Because the holotype consists mostly of giant forelimbs (2.4 m in length) with scapulocoracoids, for almost 50 years Deinocheirus has remained one of the most...

journal_title：Nature

authors： Lee YN,Barsbold R,Currie PJ,Kobayashi Y,Lee HJ,Godefroit P,Escuillié F,Chinzorig T

更新日期：2014-11-13 00:00:00

abstract：:Sleep has been assumed to be necessary for development and to be a vital function in mammals and other animals. However, Lyamin et al. claim that in bottlenose dolphins (Tursiops truncatus) and killer whales (Orcinus orca), neonates and their mothers show almost no sleep behaviour for the first month after birth; this...

journal_title：Nature

authors： Sekiguchi Y,Arai K,Kohshima S

更新日期：2006-06-22 00:00:00

abstract：:Close inbreeding is known for a variety of small mammal species for which a high probability of mortality during dispersal makes helping and delayed maturation a relatively secure fitness option. Prolonged inbreeding, however, is usually associated with lowered fitness, and it has been shown that most highly inbred sm...

journal_title：Nature

authors： O'Riain MJ,Jarvis JU,Faulkes CG

更新日期：1996-04-18 00:00:00

abstract：:Diatremes are carrot-shaped bodies forming the upper parts of very deep magmatic intrusions of kimberlite rock. These unusual, enigmatic and complex features are famous as the source of diamonds. Here we present a new model of kimberlite ascent and eruption, emphasizing the extremely unsteady nature of this process to...

journal_title：Nature

authors： Wilson L,Head Iii JW 3rd

更新日期：2007-05-03 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:Positive selection allows thymocytes that recognize an individual's own major histocompatibility complex (self-MHC) molecules to survive and differentiate, whereas negative selection removes overtly self-reactive thymocytes. Although both forms of thymic selection are mediated by the alphabeta T-cell receptor (TCR) an...

journal_title：Nature

authors： Werlen G,Hausmann B,Palmer E

更新日期：2000-07-27 00:00:00

abstract：:Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...

journal_title：Nature

authors： Vandaele AC,Korablev O,Daerden F,Aoki S,Thomas IR,Altieri F,López-Valverde M,Villanueva G,Liuzzi G,Smith MD,Erwin JT,Trompet L,Fedorova AA,Montmessin F,Trokhimovskiy A,Belyaev DA,Ignatiev NI,Luginin M,Olsen KS,Baggi

更新日期：2019-04-01 00:00:00

abstract：:Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...

journal_title：Nature

authors： Acquaviva L,Boekhout M,Karasu ME,Brick K,Pratto F,Li T,van Overbeek M,Kauppi L,Camerini-Otero RD,Jasin M,Keeney S

更新日期：2020-06-01 00:00:00

abstract：:Two approaches to the antibody-directed targeting of toxic or cytolytic activity and augmentation of cellular immune responses have been explored for tumour immunotherapy, but so far success has been limited. Obstacles facing immunotherapy are the limited accessibility of antibodies or antibody conjugates to solid tum...

journal_title：Nature

authors： Chen SY,Yang AG,Chen JD,Kute T,King CR,Collier J,Cong Y,Yao C,Huang XF

更新日期：1997-01-02 00:00:00

abstract：:The recent discovery that the human T-cell lymphoma leukemia virus (HTLV) may be the agent of transmission of T-cell lymphoid malignancies raises ethical questions for blood transfusion services. The effort to avoid use of contaminated blood is dependent to a large extent on the willingness and ability of donors to g...

journal_title：Nature

authors：

更新日期：1983-04-14 00:00:00

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2...

journal_title：Nature

authors： Kuchay S,Giorgi C,Simoneschi D,Pagan J,Missiroli S,Saraf A,Florens L,Washburn MP,Collazo-Lorduy A,Castillo-Martin M,Cordon-Cardo C,Sebti SM,Pinton P,Pagano M

更新日期：2017-06-22 00:00:00

abstract：:TMV RNA is not an efficient template for translation of the viral coat protein, in spite of containing nucleotide sequences coding for the protein. Efficient translation requires the prior synthesis within infected cells of a smaller RNA carrying only a portion of the information encoded in the whole genome. ...

journal_title：Nature

authors： Hunter TR,Hunt T,Knowland J,Zimmern D

更新日期：1976-04-29 00:00:00

abstract：:TATA-binding protein (TBP) binds the minor groove of the TATA element with the DNA bent 80 degrees towards the major groove. A constrained minicircle strategy has been used to test the effect of DNA topology on the affinity of TBP for the TATA element. We report here that TBP bound to DNA which was slightly pre-bent t...

journal_title：Nature

authors： Parvin JD,McCormick RJ,Sharp PA,Fisher DE

更新日期：1995-02-23 00:00:00

abstract：:Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning...

journal_title：Nature

authors： Elhatisari S,Lee D,Rupak G,Epelbaum E,Krebs H,Lähde TA,Luu T,Meißner UG

更新日期：2015-12-03 00:00:00

abstract：:Rimicaris exoculata is a shrimp that swarms over high-temperature (350 degrees C) sulphide chimneys at Mid-Atlantic Ridge hydrothermal fields (3,600 m). This shrimp lacks an externally differentiated eye, having instead a pair of large organs within the cephalothorax immediately beneath the dorsal surface of the trans...

journal_title：Nature

authors： Van Dover CL,Szuts EZ,Chamberlain SC,Cann JR

更新日期：1989-02-02 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:It has long been thought that mature oligodendrocytes in the adult mammalian central nervous system (CNS) are post-mitotic and are unable to proliferate in response to injury. The implications of this have been profound, because it has been suggested that this failure of oligodendrocytes to undergo mitosis is perhaps ...

journal_title：Nature

authors： Ludwin SK

更新日期：1984-03-15 00:00:00

abstract：:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cy...

journal_title：Nature

authors： Kaguni JM,Fuller RS,Kornberg A

更新日期：1982-04-15 00:00:00

abstract：:The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes ...

journal_title：Nature

authors： De Rubeis S,He X,Goldberg AP,Poultney CS,Samocha K,Cicek AE,Kou Y,Liu L,Fromer M,Walker S,Singh T,Klei L,Kosmicki J,Shih-Chen F,Aleksic B,Biscaldi M,Bolton PF,Brownfeld JM,Cai J,Campbell NG,Carracedo A,Chahrour

更新日期：2014-11-13 00:00:00