Gene inhibition using antisense oligodeoxynucleotides.

abstract：:Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...

journal_title：Nature

authors： Centonze A,Lin S,Tika E,Sifrim A,Fioramonti M,Malfait M,Song Y,Wuidart A,Van Herck J,Dannau A,Bouvencourt G,Dubois C,Dedoncker N,Sahay A,de Maertelaer V,Siebel CW,Van Keymeulen A,Voet T,Blanpain C

更新日期：2020-08-01 00:00:00

abstract：:Granular materials and ordinary fluids react differently to shear stresses. Rather than deforming uniformly, materials such as dry sand or cohesionless powders develop shear bands--narrow zones of large relative particle motion, with essentially rigid adjacent regions. Because shear bands mark areas of flow, material ...

journal_title：Nature

authors： Mueth DM,Debregeas GF,Karczmar GS,Eng PJ,Nagel SR,Jaeger HM

更新日期：2000-07-27 00:00:00

abstract：:The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies,...

journal_title：Nature

authors： Wang JH,Yan YW,Garrett TP,Liu JH,Rodgers DW,Garlick RL,Tarr GE,Husain Y,Reinherz EL,Harrison SC

更新日期：1990-11-29 00:00:00

abstract：:The abundant nuclear enzyme poly(ADP-ribose) polymerase catalyses the synthesis of poly(ADP-ribose) from nicotinamide adenine dinucleotide (NAD+). This protein has an N-terminal DNA-binding domain containing two zinc-fingers, which is linked to the C-terminal NAD(+)-binding domain by a short region containing several ...

journal_title：Nature

authors： Satoh MS,Lindahl T

更新日期：1992-03-26 00:00:00

abstract：:Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...

journal_title：Nature

authors： Gilmore CK,McCarthy SE,Spelke ES

更新日期：2007-05-31 00:00:00

abstract：:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...

journal_title：Nature

authors： Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JG

更新日期：1984-02-02 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels involved in diverse physiological processes ranging from nociception to taste. Despite the importance of ASICs in physiology, we know little about the mechanism of channel activation. Here we show that psalmotoxin activates non-sel...

journal_title：Nature

authors： Baconguis I,Gouaux E

更新日期：2012-09-20 00:00:00

abstract：:Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homolog...

journal_title：Nature

authors： Keskin H,Shen Y,Huang F,Patel M,Yang T,Ashley K,Mazin AV,Storici F

更新日期：2014-11-20 00:00:00

abstract：:The earliest cell fate decision in the mammalian embryo separates the extra-embryonic trophoblast lineage, which forms the fetal portion of the placenta, from the embryonic cell lineages. The body plan of the embryo proper is established only later at gastrulation, when the pluripotent epiblast gives rise to the germ ...

journal_title：Nature

authors： Russ AP,Wattler S,Colledge WH,Aparicio SA,Carlton MB,Pearce JJ,Barton SC,Surani MA,Ryan K,Nehls MC,Wilson V,Evans MJ

更新日期：2000-03-02 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...

journal_title：Nature

authors： Duren RM,Thorpe AK,Foster KT,Rafiq T,Hopkins FM,Yadav V,Bue BD,Thompson DR,Conley S,Colombi NK,Frankenberg C,McCubbin IB,Eastwood ML,Falk M,Herner JD,Croes BE,Green RO,Miller CE

更新日期：2019-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Greulich H,Cherniack AD

更新日期：2019-02-01 00:00:00

abstract：:Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands. In hum...

journal_title：Nature

authors： Deardorff MA,Bando M,Nakato R,Watrin E,Itoh T,Minamino M,Saitoh K,Komata M,Katou Y,Clark D,Cole KE,De Baere E,Decroos C,Di Donato N,Ernst S,Francey LJ,Gyftodimou Y,Hirashima K,Hullings M,Ishikawa Y,Jaulin C,Kaur

更新日期：2012-09-13 00:00:00

abstract：:Apolipoprotein B (apo B) is crucial for the transport of cholesterol in humans. It is a large secretory protein that mediates the uptake of low-density lipoproteins and renders several forms of lipid droplets soluble in the blood. The binding of lipid by apo B also prevents this hydrophobic protein from precipitating ...

journal_title：Nature

authors： Chuck SL,Yao Z,Blackhart BD,McCarthy BJ,Lingappa VR

更新日期：1990-07-26 00:00:00

abstract：:Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...

journal_title：Nature

authors： Wu Y,Vendome J,Shapiro L,Ben-Shaul A,Honig B

更新日期：2011-07-27 00:00:00

abstract：:An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed t...

journal_title：Nature

authors： Fu Y,Galán JE

更新日期：1999-09-16 00:00:00

abstract：:Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...

journal_title：Nature

authors： Bergerat A,de Massy B,Gadelle D,Varoutas PC,Nicolas A,Forterre P

更新日期：1997-03-27 00:00:00

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:Metamaterials are artificial optical media composed of sub-wavelength metallic and dielectric building blocks that feature optical phenomena not present in naturally occurring materials. Although they can serve as the basis for unique optical devices that mould the flow of light in unconventional ways, three-dimension...

journal_title：Nature

authors： High AA,Devlin RC,Dibos A,Polking M,Wild DS,Perczel J,de Leon NP,Lukin MD,Park H

更新日期：2015-06-11 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:The precursor frequency of T cells specific for any given foreign antigen is, in general, extremely low. Prominent exceptions to this rule are the T cells that are specific for foreign major histocompatibility complex (MHC) products or for products of the minor lymphocyte stimulatory (Mls) genes in the mouse which are...

journal_title：Nature

authors： Abe R,Vacchio MS,Fox B,Hodes RJ

更新日期：1988-10-27 00:00:00

abstract：:Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...

journal_title：Nature

authors： Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

更新日期：2018-12-01 00:00:00

abstract：:DNA winds about itself in a right-handed or left-handed fashion at several structural levels. The double helix is generally right-handed and is given a (+) sign by convention, whereas supercoiling of the helix axis is always (-) in the cell. The winding in higher -order forms such as knots and catenanes is unknown, an...

journal_title：Nature

authors： Krasnow MA,Stasiak A,Spengler SJ,Dean F,Koller T,Cozzarelli NR

更新日期：1983-08-11 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease. In particular, hMSH2 and hMLH1 homologues of the bacterial DNA mismatch repair genes mutS and mutL, respectively, were sh...

journal_title：Nature

authors： Nicolaides NC,Papadopoulos N,Liu B,Wei YF,Carter KC,Ruben SM,Rosen CA,Haseltine WA,Fleischmann RD,Fraser CM

更新日期：1994-09-01 00:00:00

abstract：:Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM, symptoms that resemble those of patients with X-linked hyper-IgM syndrome and hypohydrotic ectodermal dysplasia (XHM-ED), which is caused by mutations in NEMO (NF-κB essential modulator; also known...

journal_title：Nature

authors： Tokunaga F,Nakagawa T,Nakahara M,Saeki Y,Taniguchi M,Sakata S,Tanaka K,Nakano H,Iwai K

更新日期：2011-03-31 00:00:00

abstract：:Generalization is a cognitive ability that allows similar stimuli along a given dimension to be treated as equivalents. Insects exhibit high levels of visual generalization. Honeybees trained to recognize complex visual stimuli on the basis of a single feature generalize their choice to novel stimuli sharing that comm...

journal_title：Nature

authors： Stach S,Benard J,Giurfa M

更新日期：2004-06-17 00:00:00

abstract：:The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...

journal_title：Nature

authors： Li S,Hill CP,Sundquist WI,Finch JT

更新日期：2000-09-21 00:00:00

abstract：:Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. They were testing the hypothesis that a mutation in the CCR5 gene, frequently found in Caucasians, may have...

journal_title：Nature

authors： Elvin SJ,Williamson ED,Scott JC,Smith JN,Pérez De Lema G,Chilla S,Clapham P,Pfeffer K,Schlöndorff D,Luckow B

更新日期：2004-07-22 00:00:00

abstract：:Microscopic diamond was recently discovered in oxidized acid residues from several carbonaceous chondrite meteorites (for example, the C delta component of the Allende meteorite). Some of the reported properties of C delta seem in conflict with those expected of diamond. Here we present high spatial resolution analy...

journal_title：Nature

authors： Blake DF,Freund F,Krishnan KF,Echer CJ,Shipp R,Bunch TE,Tielens AG,Lipari RJ,Hetherington CJ,Chang S

更新日期：1988-04-14 00:00:00