Abstract：
:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functional significance of brain insulin receptors might be provided by identification of the cell type(s) possessing these receptors, we have attempted to localise them morphologically using light and electron microscope autoradiography. We report here results indicating that blood vessels throughout the CNS of the rat bind plasma insulin rapidly and with considerable specificity.
journal_name
Naturejournal_title
Natureauthors
van Houten M,Posner BIdoi
10.1038/282623a0subject
Has Abstractpub_date
1979-12-06 00:00:00pages
623-5issue
5739eissn
0028-0836issn
1476-4687journal_volume
282pub_type
杂志文章相关文献
NATURE文献大全abstract：:(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin. Enzymes of this class typically catalyse oxygenation reactions that proceed via the formation of substrate radic...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11998
更新日期：2013-04-04 00:00:00
abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0416-4
更新日期：2018-08-01 00:00:00
abstract：:If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5' to 3' fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09318
更新日期：2010-09-02 00:00:00
abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature24037
更新日期：2017-10-12 00:00:00
abstract：:The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and o...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2451-1
更新日期：2020-07-01 00:00:00
abstract：:Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/34472
更新日期：1998-01-08 00:00:00
abstract：:Methane is an important greenhouse gas that is emitted from multiple natural and anthropogenic sources. Atmospheric methane concentrations have varied on a number of timescales in the past, but what has caused these variations is not always well understood. The different sources and sinks of methane have specific isot...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature11461
更新日期：2012-10-04 00:00:00
abstract：:CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppressi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35092584
更新日期：2001-09-06 00:00:00
abstract：:Water has many kinetic and thermodynamic properties that exhibit an anomalous dependence on temperature, in particular in the supercooled phase. These anomalies have long been interpreted in terms of underlying structural causes, and their experimental characterization points to the existence of a singularity at a tem...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02409
更新日期：2004-03-18 00:00:00
abstract：:Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12980
更新日期：2014-03-27 00:00:00
abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02881
更新日期：2004-09-02 00:00:00
abstract：:In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-018-0141-z
更新日期：2018-07-01 00:00:00
abstract：:Fusion of myeloma cells and B lymphocytes to form hybridomas which produce monoclonal antibodies has been a major advance, but the poor efficiency and randomness of viral or polyethylene glycol fusion techniques generally gives poor yields of specific, high affinity antibodies. High voltage electrical fields with diel...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310792a0
更新日期：1984-08-30 00:00:00
abstract：:In several well-characterized site-specific recombination systems it has been shown that, for efficient recombination, the two recombining sites must have identical DNA sequences across the region between the staggered points of exchange. The precise DNA sequence of this overlap region, however, appears to be of littl...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/332861a0
更新日期：1988-04-28 00:00:00
abstract：:Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07780
更新日期：2009-02-19 00:00:00
abstract：:Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/35077207
更新日期：2001-05-17 00:00:00
abstract：:Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record aga...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature14258
更新日期：2015-03-12 00:00:00
abstract：:Stimulation of transient increases in intracellular calcium (Cai2+) activates protein kinases, regulates transcription and influences motility and morphology. Developing neurons generate spontaneous Cai2+ transients, but their role in directing neuronal differentiation and the way in which they encode information are ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375784a0
更新日期：1995-06-29 00:00:00
abstract：:Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1705-2
更新日期：2019-11-01 00:00:00
abstract：:Interfacing a single photon with another quantum system is a key capability in modern quantum information science. It allows quantum states of matter, such as spin states of atoms, atomic ensembles or solids, to be prepared and manipulated by photon counting and, in particular, to be distributed over long distances. S...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature16536
更新日期：2016-02-18 00:00:00
abstract：:The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35047064
更新日期：2000-12-07 00:00:00
abstract：:The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35055553
更新日期：2001-02-08 00:00:00
abstract：:Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369418a0
更新日期：1994-06-02 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,社论
doi：10.1038/d41586-019-00483-5
更新日期：2019-02-01 00:00:00
abstract：:The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature14437
更新日期：2015-04-23 00:00:00
abstract：:Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/352431a0
更新日期：1991-08-01 00:00:00
abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/384356a0
更新日期：1996-11-28 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-07328-7
更新日期：2018-11-01 00:00:00
abstract：:Sex roles are typically thought of as being fixed for a given species. In most animals males compete for females, whereas the females are more reluctant to mate. Therefore sexual selection usually acts most strongly on males. This is explained by males having a higher potential reproductive rate than females, leading ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02562
更新日期：2004-06-03 00:00:00
abstract：:In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/325445a0
更新日期：1987-01-29 00:00:00
