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NATURE文献大全abstract::Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382829a0
更新日期:1996-08-29 00:00:00
abstract::A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/275496a0
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abstract::It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346567a0
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abstract::Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0682-1
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abstract::MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relative ...
journal_title:Nature
pub_type: 杂志文章
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abstract::The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up is especially important for those with oestrogen-receptor (ER)-positive breast cancers, which can recur up to t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1007-8
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journal_title:Nature
pub_type: 杂志文章
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abstract::Recognition of objects or environmental landmarks is problematic because appearance can vary widely depending on illumination, viewing distance, angle of view and so on. Storing a separate image or 'template' for every possible view requires vast numbers to be stored and scanned, has a high probability of recognition ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001064
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abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
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journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03342
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abstract::The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative bacteria was deve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1791-1
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abstract::Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11674
更新日期:2013-01-10 00:00:00
abstract::Expansion of anthropogenic noise and night lighting across our planet1,2 is of increasing conservation concern3-6. Despite growing knowledge of physiological and behavioural responses to these stimuli from single-species and local-scale studies, whether these pollutants affect fitness is less clear, as is how and why ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2903-7
更新日期:2020-11-01 00:00:00
abstract::A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307432a0
更新日期:1984-02-02 00:00:00
abstract::In this Letter, 'released' should have been 'regulated' in the sentence starting: 'Deletion of Atg5 in the host similarly regulated circulating arginine and suppressed tumorigenesis...' This has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
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更新日期:2019-01-01 00:00:00
abstract::Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18019
更新日期:1999-03-04 00:00:00
abstract::The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1078-6
更新日期:2019-04-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTLs) detect and destroy cells displaying class I molecules of the major histocompatibility complex (MHC) that present oligopeptides derived from aberrant self or foreign proteins. Most class I peptide ligands are created from proteins that are degraded by proteasomes and transported, by the t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02240
更新日期:2004-01-15 00:00:00
abstract::The gut microbiota influences development1-3 and homeostasis4-7 of the mammalian immune system, and is associated with human inflammatory8 and immune diseases9,10 as well as responses to immunotherapy11-14. Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2971-8
更新日期:2020-12-01 00:00:00
abstract::For a system at a temperature of absolute zero, all thermal fluctuations are frozen out, while quantum fluctuations prevail. These microscopic quantum fluctuations can induce a macroscopic phase transition in the ground state of a many-body system when the relative strength of two competing energy terms is varied acro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415039a
更新日期:2002-01-03 00:00:00
abstract::Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06175
更新日期:2007-09-27 00:00:00
abstract::The flow of terrestrial groundwater to the sea is an important natural component of the hydrological cycle. This process, however, does not explain the large volumes of low-salinity groundwater that are found below continental shelves. There is mounting evidence for the global occurrence of offshore fresh and brackish...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature12858
更新日期:2013-12-05 00:00:00
abstract::Major histocompatibility complex class II molecules and their peptide ligands show unusual interaction kinetics, with slow association and dissociation rates that yield an apparent equilibrium constant of approximately 10(-6)-10(-8) M (refs 1-5). However, there is evidence for a specific, rapidly formed, short-lived c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370647a0
更新日期:1994-08-25 00:00:00
abstract::p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310589a0
更新日期:1984-08-16 00:00:00
abstract::Since the pioneering work of the Millers it has become clear that most chemical carcinogens require metabolism to reactive electrophiles and then exhibit their carcinogenic potential by reacting chemically with, and modifying, cellular macromolecules. At first modification of proteins was considered most likely to be ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287244a0
更新日期:1980-09-18 00:00:00
abstract::Excitatory amino acids induce both acute membrane depolarization and latent cellular toxicity, which often leads to apoptosis in many neurological disorders. Recent studies indicate that glutamate toxicity may involve the c-Jun amino-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases. One member of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/39899
更新日期:1997-10-23 00:00:00
abstract::Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359060a0
更新日期:1992-09-03 00:00:00
abstract::The nicotinic acetylcholine receptor (AChR) from the electroplax of the ray Torpedo californica is composed of five subunits present in a molar stoichiometry of alpha 2 beta gamma delta (refs 1-3) and contains both the binding site for the neurotransmitter and the cation gating unit (reviewed in refs 4-6). We have rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/302528a0
更新日期:1983-04-07 00:00:00
abstract::The refined 1.9-A resolution structure of the periplasmic D-galactose-binding protein (GBP) reveals a calcium ion surrounded by seven ligands, all protein oxygen atoms. A nine-residue loop (amino-acid positions 134-142), which is preceded by a beta-turn and followed by a beta-strand, provides five ligands from every s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327635a0
更新日期:1987-06-18 00:00:00
abstract::Strong interactions between electrons in a solid material can lead to surprising properties. A prime example is the Mott insulator, in which suppression of conductivity occurs as a result of interactions rather than a filled Bloch band. Proximity to the Mott insulating phase in fermionic systems is the origin of many ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07244
更新日期:2008-09-11 00:00:00