Abstract:
:A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degrees C. This indicates that the continuous expression of a viral gene product is necessary to maintain the undifferentiated state of the virus-transformed leukaemia cells.
journal_name
Naturejournal_title
Natureauthors
Graf T,Ade N,Beug Hdoi
10.1038/275496a0subject
Has Abstractpub_date
1978-10-12 00:00:00pages
496-501issue
5680eissn
0028-0836issn
1476-4687journal_volume
275pub_type
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