Interleukin-2 stimulates association of protein kinase C with plasma membrane.

abstract：:The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described...

journal_title：Nature

authors： Varnum BC,Young C,Elliott G,Garcia A,Bartley TD,Fridell YW,Hunt RW,Trail G,Clogston C,Toso RJ

更新日期：1995-02-16 00:00:00

abstract：:The src gene product, p60src, of Rous sarcoma virus (RSV) is a tyrosine-specific protein kinase which is associated with the plasma membrane of infected cells. Myristic acid is bound in an amide linkage to glycine 2 of p60src. Of the N-terminal 30 kilodaltons of p60src, only amino acids 1-14 are required for myristyla...

journal_title：Nature

authors： Pellman D,Garber EA,Cross FR,Hanafusa H

更新日期：1985-03-28 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...

journal_title：Nature

authors： Anderson RM,May RM,McLean AR

更新日期：1988-03-17 00:00:00

abstract：:We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, reveali...

journal_title：Nature

authors： Keane TM,Goodstadt L,Danecek P,White MA,Wong K,Yalcin B,Heger A,Agam A,Slater G,Goodson M,Furlotte NA,Eskin E,Nellåker C,Whitley H,Cleak J,Janowitz D,Hernandez-Pliego P,Edwards A,Belgard TG,Oliver PL,McIntyre RE,

更新日期：2011-09-14 00:00:00

abstract：:During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...

journal_title：Nature

authors： Hamazaki N,Kyogoku H,Araki H,Miura F,Horikawa C,Hamada N,Shimamoto S,Hikabe O,Nakashima K,Kitajima TS,Ito T,Leitch HG,Hayashi K

更新日期：2021-01-01 00:00:00

abstract：:THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo. It is expressed at the blastocyst stage of development, and accumulates to high levels in tissues of endodermal and mesodermal origin (H. Kim, unpublished result). After birth the gene is expressed in all tissues except skeletal m...

journal_title：Nature

authors： Bartolomei MS,Zemel S,Tilghman SM

更新日期：1991-05-09 00:00:00

abstract：:During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of pregnancy loss and several genetic disorders such as Down's syndrome. Which genes safeguard accurate pro...

journal_title：Nature

authors： Pfender S,Kuznetsov V,Pasternak M,Tischer T,Santhanam B,Schuh M

更新日期：2015-08-13 00:00:00

abstract：:Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from thr...

journal_title：Nature

authors： Roerink SF,Sasaki N,Lee-Six H,Young MD,Alexandrov LB,Behjati S,Mitchell TJ,Grossmann S,Lightfoot H,Egan DA,Pronk A,Smakman N,van Gorp J,Anderson E,Gamble SJ,Alder C,van de Wetering M,Campbell PJ,Stratton MR,Clevers

更新日期：2018-04-01 00:00:00

abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...

journal_title：Nature

authors： Seufert V,Ramankutty N,Foley JA

更新日期：2012-05-10 00:00:00

abstract：: ...

journal_title：Nature

authors： Goodman SN

更新日期：2018-12-01 00:00:00

abstract：:Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...

journal_title：Nature

authors： King IF,Yandava CN,Mabb AM,Hsiao JS,Huang HS,Pearson BL,Calabrese JM,Starmer J,Parker JS,Magnuson T,Chamberlain SJ,Philpot BD,Zylka MJ

更新日期：2013-09-05 00:00:00

abstract：:Understanding the behaviour of the dielectric constant in ferroelectric thin films remains a challenging problem. These ferroelectric materials have high static dielectric constants, and so are important for their applications in high-storage-density capacitor structures such as dynamic random access memory (DRAM). Bu...

journal_title：Nature

authors： Sirenko AA,Bernhard C,Golnik A,Clark AM,Hao J,Si W,Xi XX

更新日期：2000-03-23 00:00:00

abstract：:Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...

journal_title：Nature

authors： Acquaviva L,Boekhout M,Karasu ME,Brick K,Pratto F,Li T,van Overbeek M,Kauppi L,Camerini-Otero RD,Jasin M,Keeney S

更新日期：2020-06-01 00:00:00

abstract：:The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously identified the four-phosphate adaptor protein FAPP2, the pleckstri...

journal_title：Nature

authors： D'Angelo G,Polishchuk E,Di Tullio G,Santoro M,Di Campli A,Godi A,West G,Bielawski J,Chuang CC,van der Spoel AC,Platt FM,Hannun YA,Polishchuk R,Mattjus P,De Matteis MA

更新日期：2007-09-06 00:00:00

abstract：:Helminth parasitic infections are a major global health and social burden. The host defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-mediated immunity. Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus produ...

journal_title：Nature

authors： Gerbe F,Sidot E,Smyth DJ,Ohmoto M,Matsumoto I,Dardalhon V,Cesses P,Garnier L,Pouzolles M,Brulin B,Bruschi M,Harcus Y,Zimmermann VS,Taylor N,Maizels RM,Jay P

更新日期：2016-01-14 00:00:00

abstract：:Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTO...

journal_title：Nature

authors： Harrison DE,Strong R,Sharp ZD,Nelson JF,Astle CM,Flurkey K,Nadon NL,Wilkinson JE,Frenkel K,Carter CS,Pahor M,Javors MA,Fernandez E,Miller RA

更新日期：2009-07-16 00:00:00

abstract：:Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...

journal_title：Nature

authors： Vos SM,Farnung L,Urlaub H,Cramer P

更新日期：2018-08-01 00:00:00

abstract：:Mov13 mice carry a single Moloney murine leukaemia virus (M-MuLV) proviral copy in the first intron of the alpha 1(I) collagen gene. Virus insertion interferes with the synthesis of stable alpha 1(I) collagen messenger RNA and causes a recessive lethal mutation. The virus insertion has induced changes of the methylati...

journal_title：Nature

authors： Hartung S,Jaenisch R,Breindl M

更新日期：1986-03-27 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：:How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...

journal_title：Nature

authors： Biondi EG,Reisinger SJ,Skerker JM,Arif M,Perchuk BS,Ryan KR,Laub MT

更新日期：2006-12-14 00:00:00

abstract：:Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for...

journal_title：Nature

authors： Deckert G,Warren PV,Gaasterland T,Young WG,Lenox AL,Graham DE,Overbeek R,Snead MA,Keller M,Aujay M,Huber R,Feldman RA,Short JM,Olsen GJ,Swanson RV

更新日期：1998-03-26 00:00:00

abstract：:Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct out...

journal_title：Nature

authors： Djebali S,Davis CA,Merkel A,Dobin A,Lassmann T,Mortazavi A,Tanzer A,Lagarde J,Lin W,Schlesinger F,Xue C,Marinov GK,Khatun J,Williams BA,Zaleski C,Rozowsky J,Röder M,Kokocinski F,Abdelhamid RF,Alioto T,Antoshechkin

更新日期：2012-09-06 00:00:00

abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...

journal_title：Nature

authors： Johannessen CM,Boehm JS,Kim SY,Thomas SR,Wardwell L,Johnson LA,Emery CM,Stransky N,Cogdill AP,Barretina J,Caponigro G,Hieronymus H,Murray RR,Salehi-Ashtiani K,Hill DE,Vidal M,Zhao JJ,Yang X,Alkan O,Kim S,Harris JL

更新日期：2010-12-16 00:00:00

abstract：:Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process has, however, remained e...

journal_title：Nature

authors： Wolf F,Geisel T

更新日期：1998-09-03 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated...

journal_title：Nature

authors： Liu GH,Barkho BZ,Ruiz S,Diep D,Qu J,Yang SL,Panopoulos AD,Suzuki K,Kurian L,Walsh C,Thompson J,Boue S,Fung HL,Sancho-Martinez I,Zhang K,Yates J 3rd,Izpisua Belmonte JC

更新日期：2011-04-14 00:00:00

abstract：:Water masers are found in dense molecular clouds closely associated with supermassive black holes at the centres of active galaxies. On the basis of the understanding of the local water-maser luminosity function, it was expected that masers at intermediate and high redshifts would be extremely rare. However, galaxies ...

journal_title：Nature

authors： Impellizzeri CM,McKean JP,Castangia P,Roy AL,Henkel C,Brunthaler A,Wucknitz O

更新日期：2008-12-18 00:00:00

abstract：:A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active compe...

journal_title：Nature

authors： Carter DB,Deibel MR Jr,Dunn CJ,Tomich CS,Laborde AL,Slightom JL,Berger AE,Bienkowski MJ,Sun FF,McEwan RN

更新日期：1990-04-12 00:00:00

abstract：:Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...

journal_title：Nature

authors： van der Pluijm BA,Hall CM,Vrolijk PJ,Pevear DR,Covey MC

更新日期：2001-07-12 00:00:00

abstract：:Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...

journal_title：Nature

authors： Abbas YM,Pichlmair A,Górna MW,Superti-Furga G,Nagar B

更新日期：2013-02-07 00:00:00