Abstract:
:A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active competitive inhibitor of the binding of IL-1 to the T-cell/fibroblast form of the IL-1 receptor. Recombinant IRAP specifically inhibited IL-1 bioactivity on T cells and endothelial cells in vitro and was a potent inhibitor of IL-1 induced corticosterone production in vivo.
journal_name
Naturejournal_title
Natureauthors
Carter DB,Deibel MR Jr,Dunn CJ,Tomich CS,Laborde AL,Slightom JL,Berger AE,Bienkowski MJ,Sun FF,McEwan RNdoi
10.1038/344633a0subject
Has Abstract,Author List Incompletepub_date
1990-04-12 00:00:00pages
633-8issue
6267eissn
0028-0836issn
1476-4687journal_volume
344pub_type
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