ATP is a mediator of chemosensory transduction in the central nervous system.

abstract：:Zygotic genome activation in metazoans typically occurs several hours to a day after fertilization, and thus maternal RNAs and proteins drive early animal embryo development. In plants, despite several molecular studies of post-fertilization transcriptional activation, the timing of zygotic genome activation remains a...

journal_title：Nature

authors： Del Toro-De León G,García-Aguilar M,Gillmor CS

更新日期：2014-10-30 00:00:00

abstract：:Ultraluminous X-ray sources are extragalactic objects located outside the nucleus of the host galaxy with bolometric luminosities exceeding 10(39) erg s(-1). These extreme luminosities-if the emission is isotropic and below the theoretical (Eddington) limit, where the radiation pressure is balanced by the gravitationa...

journal_title：Nature

authors： Farrell SA,Webb NA,Barret D,Godet O,Rodrigues JM

更新日期：2009-07-02 00:00:00

abstract：:Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...

journal_title：Nature

authors： Toda S,Stein RS,Sagiya T

更新日期：2002-09-05 00:00:00

abstract：:Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an...

journal_title：Nature

authors： Saag MS,Hahn BH,Gibbons J,Li Y,Parks ES,Parks WP,Shaw GM

更新日期：1988-08-04 00:00:00

abstract：:The characterization of HIV-1 (HTLV-III/LAV), the human retrovirus associated with AIDS (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus)...

journal_title：Nature

authors： Franchini G,Gurgo C,Guo HG,Gallo RC,Collalti E,Fargnoli KA,Hall LF,Wong-Staal F,Reitz MS Jr

更新日期：1987-08-06 00:00:00

abstract：:The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...

journal_title：Nature

authors： Pätzold M,Häusler B,Bird MK,Tellmann S,Mattei R,Asmar SW,Dehant V,Eidel W,Imamura T,Simpson RA,Tyler GL

更新日期：2007-11-29 00:00:00

abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...

journal_title：Nature

authors： Perez-Ruiz E,Minute L,Otano I,Alvarez M,Ochoa MC,Belsue V,de Andrea C,Rodriguez-Ruiz ME,Perez-Gracia JL,Marquez-Rodas I,Llacer C,Alvarez M,de Luque V,Molina C,Teijeira A,Berraondo P,Melero I

更新日期：2019-05-01 00:00:00

abstract：:Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...

journal_title：Nature

authors： Chica DG,He Y,McCall KM,Chung DY,Pak RO,Trimarchi G,Liu Z,De Lurgio PM,Wessels BW,Kanatzidis MG

更新日期：2020-01-01 00:00:00

abstract：:Recognition of objects or environmental landmarks is problematic because appearance can vary widely depending on illumination, viewing distance, angle of view and so on. Storing a separate image or 'template' for every possible view requires vast numbers to be stored and scanned, has a high probability of recognition ...

journal_title：Nature

authors： Dawkins MS,Woodington A

更新日期：2000-02-10 00:00:00

abstract：:Introduced in its contemporary form in 1946 (ref. 1), but with roots that go back to the eighteenth century, the gravity law is the prevailing framework with which to predict population movement, cargo shipping volume and inter-city phone calls, as well as bilateral trade flows between nations. Despite its widespread ...

journal_title：Nature

authors： Simini F,González MC,Maritan A,Barabási AL

更新日期：2012-02-26 00:00:00

abstract：:Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic hap...

journal_title：Nature

authors： Liu P,Ji Y,Yuen T,Rendina-Ruedy E,DeMambro VE,Dhawan S,Abu-Amer W,Izadmehr S,Zhou B,Shin AC,Latif R,Thangeswaran P,Gupta A,Li J,Shnayder V,Robinson ST,Yu YE,Zhang X,Yang F,Lu P,Zhou Y,Zhu LL,Oberlin DJ,Davie

更新日期：2017-06-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Thomas et al. argue, contrary to Sala et al. that climate change poses an equal or greater threat to global biodiversity than land-use change. We contest this claim, however, on the grounds that Thomas et al. incorrectly apply species-area relationships. ...

journal_title：Nature

authors： Buckley LB,Roughgarden J

更新日期：2004-07-01 00:00:00

abstract：:Why sex prevails in nature remains one of the great puzzles of evolution. Sexual reproduction has an immediate cost relative to asexual reproduction, as males only express their contribution to population growth through females. With no males to sustain, an asexual mutant can double its relative representation in the ...

journal_title：Nature

authors： Doncaster CP,Pound GE,Cox SJ

更新日期：2000-03-16 00:00:00

abstract：:The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...

journal_title：Nature

authors： Magurran AE,Henderson PA

更新日期：2003-04-17 00:00:00

abstract：:Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in action1-3. ATP-binding cassette (ABC) exporters are highly dynamic membrane proteins that extrude a wide range of substances from the cytosol4-6 and thereby contribute to essential cellular processes, adaptive immunity and multidrug r...

journal_title：Nature

authors： Hofmann S,Januliene D,Mehdipour AR,Thomas C,Stefan E,Brüchert S,Kuhn BT,Geertsma ER,Hummer G,Tampé R,Moeller A

更新日期：2019-07-01 00:00:00

abstract：:During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

journal_title：Nature

authors： Bina CR,Navrotsky A

更新日期：2000-12-14 00:00:00

abstract：:Surface gravity is a basic stellar property, but it is difficult to measure accurately, with typical uncertainties of 25 to 50 per cent if measured spectroscopically and 90 to 150 per cent if measured photometrically. Asteroseismology measures gravity with an uncertainty of about 2 per cent but is restricted to relati...

journal_title：Nature

authors： Bastien FA,Stassun KG,Basri G,Pepper J

更新日期：2013-08-22 00:00:00

abstract：:The class II region of the human major histocompatibility complex (MHC) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. Each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (Mr) 34,000 (34 K) and a beta-chain of Mr = 28K. The...

journal_title：Nature

authors： Hardy DA,Bell JI,Long EO,Lindsten T,McDevitt HO

更新日期：1986-10-02 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00

abstract：:The interaction of lectins with carbohydrate receptors on the plasma membrane of eukaryotic cells results in a wide variety of biological effects. One effect which has been extensively studied is the stimulation of lymphocytes to blastogenesis and proliferation. High doses of concanavalin A (Con A) and phytohaemagglut...

journal_title：Nature

authors： Hilgert I,Horejsí V,Angelisová P,Kristofová H

更新日期：1980-03-20 00:00:00

abstract：:Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...

journal_title：Nature

authors： Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2012-10-18 00:00:00

abstract：:The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein. ...

journal_title：Nature

authors： Adhya S,Miller W

更新日期：1979-06-07 00:00:00

abstract：:Joining dissimilar materials such as plastics and metals in engineered structures remains a challenge1. Mechanical fastening, conventional welding and adhesive bonding are examples of techniques currently used for this purpose, but each of these methods presents its own set of problems2 such as formation of stress con...

journal_title：Nature

authors： Rivera J,Hosseini MS,Restrepo D,Murata S,Vasile D,Parkinson DY,Barnard HS,Arakaki A,Zavattieri P,Kisailus D

更新日期：2020-10-01 00:00:00

abstract：:Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...

journal_title：Nature

authors： Trautmann A

更新日期：1982-07-15 00:00:00

abstract：:Topological physics relies on the structure of the eigenstates of the Hamiltonians. The geometry of the eigenstates is encoded in the quantum geometric tensor1-comprising the Berry curvature2 (crucial for topological matter)3 and the quantum metric4, which defines the distance between the eigenstates. Knowledge of the...

journal_title：Nature

authors： Gianfrate A,Bleu O,Dominici L,Ardizzone V,De Giorgi M,Ballarini D,Lerario G,West KW,Pfeiffer LN,Solnyshkov DD,Sanvitto D,Malpuech G

更新日期：2020-02-01 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...

journal_title：Nature

authors： Wilken T,Curto GL,Probst RA,Steinmetz T,Manescau A,Pasquini L,González Hernández JI,Rebolo R,Hänsch TW,Udem T,Holzwarth R

更新日期：2012-05-30 00:00:00

abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...

journal_title：Nature

authors： Yu W,Gius D,Onyango P,Muldoon-Jacobs K,Karp J,Feinberg AP,Cui H

更新日期：2008-01-10 00:00:00

abstract：:The development of a eutherian mammal as a male is a consequence of testis formation in the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence of this gene, ovaries are formed and female characteristics develop. Sex determination therefore hinges on the action of this testis-determi...

journal_title：Nature

authors： Koopman P,Münsterberg A,Capel B,Vivian N,Lovell-Badge R

更新日期：1990-11-29 00:00:00