Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.

abstract：:Abyssal-hill-bounding faults that pervade the oceanic crust are the most common tectonic feature on the surface of the Earth. The recognition that these faults form at plate spreading centres came with the plate tectonic revolution. Recent observations reveal a large range of fault sizes and orientations; numerical mo...

journal_title：Nature

authors： Buck WR,Lavier LL,Poliakov AN

更新日期：2005-04-07 00:00:00

abstract：:Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and maintenance, and has been shown to depend on GTP hydrolysis. Here we demonstrate that Drosophila Atlastin--the fly homologue of the mammalian GTPase atl...

journal_title：Nature

authors： Orso G,Pendin D,Liu S,Tosetto J,Moss TJ,Faust JE,Micaroni M,Egorova A,Martinuzzi A,McNew JA,Daga A

更新日期：2009-08-20 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...

journal_title：Nature

authors： Li B,Qiu B,Lee DS,Walton ZE,Ochocki JD,Mathew LK,Mancuso A,Gade TP,Keith B,Nissim I,Simon MC

更新日期：2014-09-11 00:00:00

abstract：:To achieve stereoscopic vision, the brain must search for corresponding image features on the two retinas. As long as the eyes stay still, corresponding features are confined to narrow bands called epipolar lines. But when the eyes change position, the epipolar lines migrate on the retinas. To find the matching featur...

journal_title：Nature

authors： Schreiber K,Crawford JD,Fetter M,Tweed D

更新日期：2001-04-12 00:00:00

abstract：:The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...

journal_title：Nature

authors： Parfitt SA,Ashton NM,Lewis SG,Abel RL,Coope GR,Field MH,Gale R,Hoare PG,Larkin NR,Lewis MD,Karloukovski V,Maher BA,Peglar SM,Preece RC,Whittaker JE,Stringer CB

更新日期：2010-07-08 00:00:00

abstract：:Susceptibility to some human diseases is linked, albeit weakly, to major transplantation antigens (HLA) encoded by the major histocompatibility gene complex (MHC). Here we have studied MHC/disease association in inbred strains of mice after intracerebral (i.c.) injection of lymphocytic choriomeningitis virus (LCMV). T...

journal_title：Nature

authors： Zinkernagel RM,Pfau CJ,Hengartner H,Althage A

更新日期：1985-08-29 00:00:00

abstract：:The monarch butterfly, Danaus plexippus, is famous for its spectacular annual migration across North America, recent worldwide dispersal, and orange warning colouration. Despite decades of study and broad public interest, we know little about the genetic basis of these hallmark traits. Here we uncover the history of t...

journal_title：Nature

authors： Zhan S,Zhang W,Niitepõld K,Hsu J,Haeger JF,Zalucki MP,Altizer S,de Roode JC,Reppert SM,Kronforst MR

更新日期：2014-10-16 00:00:00

abstract：:Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developm...

journal_title：Nature

authors： Fernandez-Leiro R,Scheres SH

更新日期：2016-09-15 00:00:00

abstract：:Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...

journal_title：Nature

authors： Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her

更新日期：2015-11-19 00:00:00

abstract：:The primary action of a family of mitogens including bombesin, bradykinin, vasopressin and alpha-thrombin is to activate the hydrolysis of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phospholipase C is mediated through coupling of surface receptors to a GTP-binding pro...

journal_title：Nature

authors： Chambard JC,Paris S,L'Allemain G,Pouysségur J

更新日期：1987-04-23 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

更新日期：2020-01-01 00:00:00

abstract：:A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme. ...

journal_title：Nature

authors： Woolley P

更新日期：1975-12-25 00:00:00

abstract：:The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and editing of major histocompatibility complex class I (...

journal_title：Nature

authors： Blees A,Januliene D,Hofmann T,Koller N,Schmidt C,Trowitzsch S,Moeller A,Tampé R

更新日期：2017-11-23 00:00:00

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00

abstract：:The development of a eutherian mammal as a male is a consequence of testis formation in the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence of this gene, ovaries are formed and female characteristics develop. Sex determination therefore hinges on the action of this testis-determi...

journal_title：Nature

authors： Koopman P,Münsterberg A,Capel B,Vivian N,Lovell-Badge R

更新日期：1990-11-29 00:00:00

abstract：:The nicotinic acetylcholine receptor (AChR) from the electroplax of the ray Torpedo californica is composed of five subunits present in a molar stoichiometry of alpha 2 beta gamma delta (refs 1-3) and contains both the binding site for the neurotransmitter and the cation gating unit (reviewed in refs 4-6). We have rec...

journal_title：Nature

authors： Noda M,Takahashi H,Tanabe T,Toyosato M,Kikyotani S,Furutani Y,Hirose T,Takashima H,Inayama S,Miyata T,Numa S

更新日期：1983-04-07 00:00:00

abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....

journal_title：Nature

authors： Tsai WW,Wang Z,Yiu TT,Akdemir KC,Xia W,Winter S,Tsai CY,Shi X,Schwarzer D,Plunkett W,Aronow B,Gozani O,Fischle W,Hung MC,Patel DJ,Barton MC

更新日期：2010-12-16 00:00:00

abstract：:Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O2-) and hydrogen peroxide (H2O2). This oxidative burst drives crosslinking of the cell wall, induces several plant genes involved in cellular protection and defence, and is necessary for the initiation ...

journal_title：Nature

authors： Delledonne M,Xia Y,Dixon RA,Lamb C

更新日期：1998-08-06 00:00:00

abstract：:Since the pioneering work of the Millers it has become clear that most chemical carcinogens require metabolism to reactive electrophiles and then exhibit their carcinogenic potential by reacting chemically with, and modifying, cellular macromolecules. At first modification of proteins was considered most likely to be ...

journal_title：Nature

authors： Allen JA,Coombs MM

更新日期：1980-09-18 00:00:00

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...

journal_title：Nature

authors： Erickson CL

更新日期：2000-11-09 00:00:00

abstract：:One of the most exciting events in recent years in molecular biology was the discovery of the left-handed Z form of the DNA double helix. Originally found in linear self-complementary d(GC)x . d(GC)x polymers and oligomers in non-physiological conditions (a rather high salt concentration), it was recently shown to be ...

journal_title：Nature

authors： Frank-Kamenetskii MD,Vologodskii AV

更新日期：1984-02-02 00:00:00

abstract：:Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...

journal_title：Nature

authors： Eden S,Rohatgi R,Podtelejnikov AV,Mann M,Kirschner MW

更新日期：2002-08-15 00:00:00

abstract：:Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing. ...

journal_title：Nature

authors： Watson A,Smaldon N,Lucke R,Hawkins T

更新日期：1993-04-08 00:00:00

abstract：:Sex-determination genes are among the most fluid features of the genome in many groups of animals. In some taxa the master sex-determining gene moves frequently between chromosomes, whereas in other taxa different genes have been recruited to determine the sex of the zygotes. There is a well developed theory for the o...

journal_title：Nature

authors： van Doorn GS,Kirkpatrick M

更新日期：2007-10-18 00:00:00

abstract：:Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. Here we resolve these inconsistencies and show th...

journal_title：Nature

authors： Sigl M,Winstrup M,McConnell JR,Welten KC,Plunkett G,Ludlow F,Büntgen U,Caffee M,Chellman N,Dahl-Jensen D,Fischer H,Kipfstuhl S,Kostick C,Maselli OJ,Mekhaldi F,Mulvaney R,Muscheler R,Pasteris DR,Pilcher JR,Salzer M,

更新日期：2015-07-30 00:00:00

abstract：:Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amphiphilic peptides have been found to form ion channels5,6, and there h...

journal_title：Nature

authors： Xu C,Lu P,Gamal El-Din TM,Pei XY,Johnson MC,Uyeda A,Bick MJ,Xu Q,Jiang D,Bai H,Reggiano G,Hsia Y,Brunette TJ,Dou J,Ma D,Lynch EM,Boyken SE,Huang PS,Stewart L,DiMaio F,Kollman JM,Luisi BF,Matsuura T,Catterall

更新日期：2020-09-01 00:00:00

abstract：:Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...

journal_title：Nature

authors： Kessels HW,Nguyen LN,Nabavi S,Malinow R

更新日期：2010-08-12 00:00:00

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...

journal_title：Nature

authors： Simmons RM,Szent-Györgyi AG

更新日期：1980-08-07 00:00:00