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NATURE文献大全abstract::Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature18624
更新日期:2016-07-21 00:00:00
abstract::The nucleotides immediately surrounding intron/exon junctions of genes transcribed by RNA polymerase B can be derived from 'consensus' sequences for donor and acceptor splice sites by only a few base changes. Studies in vivo have underlined the importance of these junction nucleotides for splicing. In higher eukaryote...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315430a0
更新日期:1985-05-30 00:00:00
abstract::During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-3027-9
更新日期:2021-01-01 00:00:00
abstract::Neuroblastoma, the most common paediatric solid tumour, arises from defective neural crest cells. Genetic alterations occur frequently in the most aggressive neuroblastomas. In particular, deletion or suppression of the proapoptotic enzyme caspase-8 is common in malignant, disseminated disease, although the effect of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04323
更新日期:2006-01-05 00:00:00
abstract::Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4(+) T cells. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14053
更新日期:2015-01-15 00:00:00
abstract::Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09440
更新日期:2010-09-30 00:00:00
abstract::The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13772
更新日期:2014-11-13 00:00:00
abstract::Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome. However, it remains unclear how th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04896
更新日期:2006-07-27 00:00:00
abstract::Zygotic genome activation in metazoans typically occurs several hours to a day after fertilization, and thus maternal RNAs and proteins drive early animal embryo development. In plants, despite several molecular studies of post-fertilization transcriptional activation, the timing of zygotic genome activation remains a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13620
更新日期:2014-10-30 00:00:00
abstract::The identical structure of two racially distinct alpha 1-globin alleles and the high degree of homology between the alpha 1- and alpha 2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the alpha-globin gene complex. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290026a0
更新日期:1981-03-05 00:00:00
abstract::The opening and closing of voltage-activated Na+, Ca2+ and K+ (Kv) channels underlies electrical and chemical signalling throughout biology, yet the structural basis of voltage sensing is unknown. Hanatoxin is a tarantula toxin that inhibits Kv channels by binding to voltage-sensor paddles, crucial helix-turn-helix mo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03873
更新日期:2005-08-11 00:00:00
abstract::Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/46286
更新日期:1999-11-18 00:00:00
abstract::Retinoic acid may be the natural morphogen used to generate digit pattern in the chick limb bud. It has been proposed that retinoic acid acts by binding to a cellular retinoic acid-binding protein (CRABP) and then entering the nucleus to alter the pattern of gene activity. High-affinity receptors that bind both retino...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335733a0
更新日期:1988-10-20 00:00:00
abstract::Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolites are extremely rare. The fluoride ion is a potent nucleophile in its desolvated state, but is tightly hydrated in water and effectively inert. Low availability and a la...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02280
更新日期:2004-02-05 00:00:00
abstract::The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304275a0
更新日期:1983-07-21 00:00:00
abstract::In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity. These ion transporters are functionally diverse: they can function as Na(+) or K(+) channels and possibly as cation/K(+) symporters. They ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12055
更新日期:2013-04-18 00:00:00
abstract::The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12640
更新日期:2013-11-28 00:00:00
abstract::Muscle actin genes are the earliest yet described to show cell type-specific activation in amphibian embryos. Gene-specific probes show that alpha-skeletal and alpha-cardiac actin genes start to be transcribed simultaneously at the end of gastrulation, but only in those regions of the mesoderm that subsequently form e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/311716a0
更新日期:1984-10-25 00:00:00
abstract::Crystalline materials are crucial to the function of living organisms, in the shells of molluscs, the matrix of bone, the teeth of sea urchins, and the exoskeletons of coccoliths. However, pathological biomineralization can be an undesirable crystallization process associated with human diseases. The crystal growth of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19062
更新日期:2016-08-25 00:00:00
abstract::Fungi are the principal degraders of biomass in terrestrial ecosystems and establish important interactions with plants and animals. However, our current understanding of fungal evolutionary diversity is incomplete and is based upon species amenable to growth in culture. These culturable fungi are typically yeast or f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09984
更新日期:2011-05-11 00:00:00
abstract::The homotypic fusion of yeast vacuoles includes a 'docking' step, which we show here to consist of two sequential reactions: a reversible 'tethering' mediated by the GTPase Ypt7, and 'SNARE pairing', in which SNARE proteins from opposite membranes form a complex in trans. The function of this trans-SNARE complex must ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25069
更新日期:1998-12-10 00:00:00
abstract::Hydrolysis of the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) produces two prospective intracellular messengers: inositol 1,4,5-trisphosphate (InsP3), which releases Ca2+ from intracellular stores; and diacylglycerol (DG), which activates protein kinase C. Here we show how the formation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323333a0
更新日期:1986-09-25 00:00:00
abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02624
更新日期:2004-05-27 00:00:00
abstract::Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22365
更新日期:2017-05-25 00:00:00
abstract::Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoprotein...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364771a0
更新日期:1993-08-26 00:00:00
abstract::Colorectal cancer results from mutations in components of the Wnt pathway that regulate beta-catenin levels. Dishevelled (Dvl or Dsh) signals downstream of Wnt receptors and stabilizes beta-catenin during cell proliferation and embryonic axis formation. Moreover, Dvl contributes to cytoskeletal reorganization during g...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01056
更新日期:2002-10-17 00:00:00
abstract::Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23674
更新日期:2017-10-05 00:00:00
abstract::The dopa analogue 6-fluorodopa (6-FD) used with positron emission tomography (PET) allows in vivo visualization of dopamine and its metabolites in nigrostriatal nerve endings. We have now found abnormal 6-FD scans in four subjects exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). None had parkinsonism. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317246a0
更新日期:1985-09-19 00:00:00
abstract::The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0864-x
更新日期:2019-02-01 00:00:00
abstract::The three-dimensional organization of the genome supports regulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis. Chromosome conformation capture (Hi-C)1,2 analysis has revealed a complex genomic landscape of internal chromosomal structures in vertebrate cells3-7, but the ident...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2744-4
更新日期:2020-10-01 00:00:00