Abstract:
:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both the acquisition and expression of learned fear responses. Freezing to a conditioned tone is enhanced following damage to the dorsal part of the medial prefrontal cortex, indicating that this area may be involved in fear reduction. Here we show that prefrontal neurons reduce their spontaneous activity in the presence of a conditioned aversive tone as a function of the degree of fear. The depression in prefrontal spontaneous activity is related to amygdala activity but not to the freezing response itself. These data indicate that, in the presence of threatening stimuli, the amygdala controls both fear expression and prefrontal neuronal activity. They suggest that abnormal amygdala-induced modulation of prefrontal neuronal activity may be involved in the pathophysiology of certain forms of anxiety disorder.
journal_name
Naturejournal_title
Natureauthors
Garcia R,Vouimba RM,Baudry M,Thompson RFdoi
10.1038/46286keywords:
subject
Has Abstractpub_date
1999-11-18 00:00:00pages
294-6issue
6759eissn
0028-0836issn
1476-4687journal_volume
402pub_type
杂志文章相关文献
NATURE文献大全abstract::Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07534
更新日期:2008-12-04 00:00:00
abstract::Retrotransposons, which proliferate by reverse transcription of RNA intermediates, comprise a major portion of plant genomes. Plants often change the genome size and organization during evolution by rapid proliferation and deletion of long terminal repeat (LTR) retrotransposons. Precise transposon sequences throughout...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08351
更新日期:2009-09-17 00:00:00
abstract::Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10751
更新日期:2012-01-29 00:00:00
abstract::The ATP-dependent chromatin assembly and remodelling factor (ACF) functions to generate regularly spaced nucleosomes, which are required for heritable gene silencing. The mechanism by which ACF mobilizes nucleosomes remains poorly understood. Here we report a single-molecule FRET study that monitors the remodelling of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08627
更新日期:2009-12-24 00:00:00
abstract::The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328267a0
更新日期:1987-07-16 00:00:00
abstract::The Altai region of Siberia was inhabited for parts of the Pleistocene by at least two groups of archaic hominins-Denisovans and Neanderthals. Denisova Cave, uniquely, contains stratified deposits that preserve skeletal and genetic evidence of both hominins, artefacts made from stone and other materials, and a range o...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-018-0843-2
更新日期:2019-01-01 00:00:00
abstract::Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12942
更新日期:2014-03-06 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07589-2
更新日期:2018-12-01 00:00:00
abstract::During attempts to select nonsecretory variants from 0.467.3, and Epstein-Barr virus-transformed human lymphoblastoid cell line that secretes small amounts of IgM lambda, we exposed the cells to UV light. Cells that survived the irradiation were subcultured and their supernatants were screened for immunoglobulin produ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306189a0
更新日期:1983-11-10 00:00:00
abstract::Abyssal-hill-bounding faults that pervade the oceanic crust are the most common tectonic feature on the surface of the Earth. The recognition that these faults form at plate spreading centres came with the plate tectonic revolution. Recent observations reveal a large range of fault sizes and orientations; numerical mo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03358
更新日期:2005-04-07 00:00:00
abstract::The methylation of vertebrate DNA at the 5-position of approximately 3-10% of its cytosine residues occurs in a sequence-specific and tissue-specific manner and has been implicated in the control of transcription. How these differences are established and how they mediate the initiation or maintenance of transcription...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308293a0
更新日期:1984-03-15 00:00:00
abstract::Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356215a0
更新日期:1992-03-19 00:00:00
abstract::Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326793a0
更新日期:1987-04-23 00:00:00
abstract::The ability to trap an object-whether a single atom or a macroscopic entity-affects fields as diverse as quantum optics, soft condensed-matter physics, biophysics and clinical medicine. Many sophisticated methodologies have been developed to counter the randomizing effect of Brownian motion in solution, but stable tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09404
更新日期:2010-10-07 00:00:00
abstract::The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343263a0
更新日期:1990-01-18 00:00:00
abstract::Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07861
更新日期:2009-05-07 00:00:00
abstract::A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs). The current model posits that Dicer selects cleavage sites by measuring a set distance from th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10198
更新日期:2011-07-13 00:00:00
abstract::The first zygotic genes to be expressed during early Drosophila development are the gap genes. Their role is to read and interpret coarse positional information deposited in the egg by the mother and to refine it by cross-regulatory interactions and by controlling a class of pair-rule genes. Little is known about the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341335a0
更新日期:1989-09-28 00:00:00
abstract::Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35050141
更新日期:2000-12-21 00:00:00
abstract::The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09278
更新日期:2010-08-05 00:00:00
abstract::The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/30965
更新日期:1998-06-04 00:00:00
abstract::Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282098a0
更新日期:1979-11-01 00:00:00
abstract::The alpha-helix defined in 1951 by Pauling et al. on the basis of model building and X-ray fibre diffraction data has 3.65 residues per turn (n) achieved with planar peptides, torsion angles of phi = -48 degrees and psi = -57 degrees and hydrogen bonds which are close to linear. Although X-ray analyses of proteins hav...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306281a0
更新日期:1983-11-17 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 面试
doi:10.1038/d41586-018-07198-z
更新日期:2018-11-01 00:00:00
abstract::Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00906
更新日期:2002-08-01 00:00:00
abstract::Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13374
更新日期:2014-07-17 00:00:00
abstract::Genetic models predict that genomic rearrangement in hybrids can facilitate reproductive isolation and the formation of new species by preventing gene flow between the parent species and hybrid (sunflowers are an example). The mechanism underlying hybridization-induced chromosome remodelling is as yet unknown, althoug...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29985
更新日期:1998-05-07 00:00:00
abstract::Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01739
更新日期:2003-07-03 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07193-4
更新日期:2018-11-01 00:00:00
abstract::Prized for their ability to rapidly generate chemical complexity by building new ring systems and stereocentres1, cycloaddition reactions have featured in numerous total syntheses2 and are a key component in the education of chemistry students3. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to syn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0391-9
更新日期:2018-08-01 00:00:00