A transcription factor response element for gene expression during circadian night.

abstract：:Plants can have positive effects on each other. For example, the accumulation of nutrients, provision of shade, amelioration of disturbance, or protection from herbivores by some species can enhance the performance of neighbouring species. Thus the notion that the distributions and abundances of plant species are inde...

journal_title：Nature

authors： Callaway RM,Brooker RW,Choler P,Kikvidze Z,Lortie CJ,Michalet R,Paolini L,Pugnaire FI,Newingham B,Aschehoug ET,Armas C,Kikodze D,Cook BJ

更新日期：2002-06-20 00:00:00

abstract：:Down's syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation. Development of the DS brain is associated with decreased neuronal number and abnormal neuronal differentiation, and adults with DS develop Alzheimer's disease. The cause of the neurodegenerative process in DS is unknown. Here we...

journal_title：Nature

authors： Busciglio J,Yankner BA

更新日期：1995-12-21 00:00:00

abstract：:How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...

journal_title：Nature

authors： Johnston RJ,Hobert O

更新日期：2003-12-18 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi's sarcoma and in primary-effusion (body-cavity-based) lymphomas, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpesvirus with homo...

journal_title：Nature

authors： Arvanitakis L,Geras-Raaka E,Varma A,Gershengorn MC,Cesarman E

更新日期：1997-01-23 00:00:00

abstract：:Quantum criticality is associated with a system composed of a nearly infinite number of interacting quantum degrees of freedom at zero temperature, and it implies that the system looks on average the same regardless of the time- and length scale on which it is observed. Electrons on the atomic scale do not exhibit suc...

journal_title：Nature

authors： van der Marel D,Molegraaf HJ,Zaanen J,Nussinov Z,Carbone F,Damascelli A,Eisaki H,Greven M,Kes PH,Li M

更新日期：2003-09-18 00:00:00

abstract：:Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...

journal_title：Nature

authors： Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

更新日期：1986-03-06 00:00:00

abstract：:The pathways that control insulin secretion and regulate pancreatic beta-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic beta-cell function, and the consequences of mutations in these genes are so serio...

journal_title：Nature

authors： Bell GI,Polonsky KS

更新日期：2001-12-13 00:00:00

abstract：:We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions...

journal_title：Nature

authors： Wood V,Gwilliam R,Rajandream MA,Lyne M,Lyne R,Stewart A,Sgouros J,Peat N,Hayles J,Baker S,Basham D,Bowman S,Brooks K,Brown D,Brown S,Chillingworth T,Churcher C,Collins M,Connor R,Cronin A,Davis P,Feltwell T,Fr

更新日期：2002-02-21 00:00:00

abstract：:Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...

journal_title：Nature

authors： Manoury B,Hewitt EW,Morrice N,Dando PM,Barrett AJ,Watts C

更新日期：1998-12-17 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:Graphene oxide membranes-partially oxidized, stacked sheets of graphene-can provide ultrathin, high-flux and energy-efficient membranes for precise ionic and molecular sieving in aqueous solution. These materials have shown potential in a variety of applications, including water desalination and purification, gas and ...

journal_title：Nature

authors： Chen L,Shi G,Shen J,Peng B,Zhang B,Wang Y,Bian F,Wang J,Li D,Qian Z,Xu G,Liu G,Zeng J,Zhang L,Yang Y,Zhou G,Wu M,Jin W,Li J,Fang H

更新日期：2017-10-19 00:00:00

abstract：:In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...

journal_title：Nature

authors： Andersen TG,Naseer S,Ursache R,Wybouw B,Smet W,De Rybel B,Vermeer JEM,Geldner N

更新日期：2018-07-01 00:00:00

abstract：:One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this ...

journal_title：Nature

authors： Weaver BA,Silk AD,Cleveland DW

更新日期：2006-08-17 00:00:00

abstract：:The polypeptide chains that make up proteins have thousands of atoms and hence millions of possible inter-atomic interactions. It might be supposed that the resulting complexity would make prediction of protein structure and protein-folding mechanisms nearly impossible. But the fundamental physics underlying folding m...

journal_title：Nature

authors： Baker D

更新日期：2000-05-04 00:00:00

abstract：:Large, actively swimming suspension feeders evolved several times in Earth's history, arising independently from groups as diverse as sharks, rays and stem teleost fishes, and in mysticete whales. However, animals occupying this niche have not been identified from the early Palaeozoic era. Anomalocarids, a group of st...

journal_title：Nature

authors： Vinther J,Stein M,Longrich NR,Harper DA

更新日期：2014-03-27 00:00:00

abstract：:Oxygen consumption by carnivorous reptiles increases enormously after they have eaten a large meal in order to meet metabolic demands, and this places an extra load on the cardiovascular system. Here we show that there is an extraordinarily rapid 40% increase in ventricular muscle mass in Burmese pythons (Python molur...

journal_title：Nature

authors： Andersen JB,Rourke BC,Caiozzo VJ,Bennett AF,Hicks JW

更新日期：2005-03-03 00:00:00

abstract：:Biodegradation of crude oil by bacterial activity--which has occurred in the majority of the Earth's oil reserves--is known to reduce greatly the quality of petroleum in reservoirs. For economically successful prospecting for oil, it is therefore important to understand the processes and conditions in geological forma...

journal_title：Nature

authors： Wilhelms A,Larter SR,Head I,Farrimond P,di-Primio R,Zwach C

更新日期：2001-06-28 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:Electron transfer reactions are essential for life because they underpin oxidative phosphorylation and photosynthesis, processes leading to the generation of ATP, and are involved in many reactions of intermediary metabolism. Key to these roles is the formation of transient inter-protein electron transfer complexes. T...

journal_title：Nature

authors： Antonyuk SV,Han C,Eady RR,Hasnain SS

更新日期：2013-04-04 00:00:00

abstract：:The regulation of intracellular pH (pHi) is essential for normal cell function, and controlled changes in pHi may play a central role in cell activation. Sodium-dependent Cl-HCO3 exchange is the dominant mechanism of pHi regulation in the invertebrate cells examined, and also occurs in mammalian cells. The transporter...

journal_title：Nature

authors： Boron WF,Hogan E,Russell JM

更新日期：1988-03-17 00:00:00

abstract：:Hydrophobic signal-sequences direct the transfer of secretory proteins across the inner membrane of prokaryotes and the endoplasmic reticulum membranes of eukaryotes. In mammalian cells, signal-sequences are recognized by the 54K protein (M(r) 54,000) of the signal recognition particle (SRP) which is believed to hold ...

journal_title：Nature

authors： Luirink J,High S,Wood H,Giner A,Tollervey D,Dobberstein B

更新日期：1992-10-22 00:00:00

abstract：:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...

journal_title：Nature

authors： Pin JP,Bettler B

更新日期：2016-12-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian nervous system, is known to operate bicuculline-sensitive Cl- channels through GABAA receptors and bicuculline-insensitive cation channels through GABAB receptors. Recent observations indicate that the retina may contain GABA receptor...

journal_title：Nature

authors： Feigenspan A,Wässle H,Bormann J

更新日期：1993-01-14 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...

journal_title：Nature

authors： Obmolova G,Ban C,Hsieh P,Yang W

更新日期：2000-10-12 00:00:00

abstract：:T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively. However, peripheral T-cell deletion takes place in...

journal_title：Nature

authors： Zheng L,Fisher G,Miller RE,Peschon J,Lynch DH,Lenardo MJ

更新日期：1995-09-28 00:00:00

abstract：:Many intracellular targets of protein-tyrosine kinases possess Src homology 2 (SH2) domains that directly recognize phosphotyrosine-containing sites on autophosphorylated growth factor receptors and cytoplasmic proteins, and thereby mediate the activation of biochemical signalling pathways. SH2 domains possess relativ...

journal_title：Nature

authors： Marengere LE,Songyang Z,Gish GD,Schaller MD,Parsons JT,Stern MJ,Cantley LC,Pawson T

更新日期：1994-06-09 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:Dynamic access to genetic information is central to organismal development and environmental response. Consequently, genomic processes must be regulated by mechanisms that alter genome function relatively rapidly. Conventional chromatin immunoprecipitation (ChIP) experiments measure transcription factor occupancy, but...

journal_title：Nature

authors： Lickwar CR,Mueller F,Hanlon SE,McNally JG,Lieb JD

更新日期：2012-04-11 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00