Abstract:
:One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.
journal_name
Naturejournal_title
Natureauthors
Weaver BA,Silk AD,Cleveland DWdoi
10.1038/nature05139subject
Has Abstractpub_date
2006-08-17 00:00:00pages
E9-10; discussion E10issue
7104eissn
0028-0836issn
1476-4687pii
nature05139journal_volume
442pub_type
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