Cell biology: nondisjunction, aneuploidy and tetraploidy.

Abstract:

:One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.

journal_name

Nature

journal_title

Nature

authors

Weaver BA,Silk AD,Cleveland DW

doi

10.1038/nature05139

subject

Has Abstract

pub_date

2006-08-17 00:00:00

pages

E9-10; discussion E10

issue

7104

eissn

0028-0836

issn

1476-4687

pii

nature05139

journal_volume

442

pub_type

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