Structure of serum response factor core bound to DNA.

abstract：:Recent studies have shown that short chemically synthesized peptides very often induce antibodies which react with the cognate sequence in the intact folded protein. Since such antibodies react with known regions of proteins, they are of predetermined specificity and offer a precision not previously possible with immu...

journal_title：Nature

authors： Alexander H,Johnson DA,Rosen J,Jerabek L,Green N,Weissman IL,Lerner RA

更新日期：1983-12-15 00:00:00

abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...

journal_title：Nature

authors： Lukas J,Parry D,Aagaard L,Mann DJ,Bartkova J,Strauss M,Peters G,Bartek J

更新日期：1995-06-08 00:00:00

abstract：:Exoplanet detections have revolutionized astronomy, offering new insights into solar system architecture and planet demographics. While nearly 1,900 exoplanets have now been discovered and confirmed, none are still in the process of formation. Transition disks, protoplanetary disks with inner clearings best explained ...

journal_title：Nature

authors： Sallum S,Follette KB,Eisner JA,Close LM,Hinz P,Kratter K,Males J,Skemer A,Macintosh B,Tuthill P,Bailey V,Defrère D,Morzinski K,Rodigas T,Spalding E,Vaz A,Weinberger AJ

更新日期：2015-11-19 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00

abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...

journal_title：Nature

authors： Rausher MD

更新日期：2001-06-14 00:00:00

abstract：:Post-translational modification (PTM) of proteins plays an important part in mediating protein interactions and/or the recruitment of specific protein targets. PTM can be mediated by the addition of functional groups (for example, acetylation or phosphorylation), peptides (for example, ubiquitylation or sumoylation), ...

journal_title：Nature

authors： Ahel I,Ahel D,Matsusaka T,Clark AJ,Pines J,Boulton SJ,West SC

更新日期：2008-01-03 00:00:00

abstract：:The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...

journal_title：Nature

authors： Paquet D,Kwart D,Chen A,Sproul A,Jacob S,Teo S,Olsen KM,Gregg A,Noggle S,Tessier-Lavigne M

更新日期：2016-05-05 00:00:00

abstract：:Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...

journal_title：Nature

authors： Xu P,Widmer G,Wang Y,Ozaki LS,Alves JM,Serrano MG,Puiu D,Manque P,Akiyoshi D,Mackey AJ,Pearson WR,Dear PH,Bankier AT,Peterson DL,Abrahamsen MS,Kapur V,Tzipori S,Buck GA

更新日期：2004-10-28 00:00:00

abstract：:The cellular response to hypoxia is critical for cell survival and is fine-tuned to allow cells to recover from hypoxic stress and adapt to heterogeneous or fluctuating oxygen levels. The hypoxic response is mediated by the α-subunit of the transcription factor HIF-1 (HIF-1α), which interacts through its intrinsically...

journal_title：Nature

authors： Berlow RB,Dyson HJ,Wright PE

更新日期：2017-03-16 00:00:00

abstract：:Dusty disks around young stars are formed out of interstellar dust that consists of amorphous, submicrometre grains. Yet the grains found in comets and meteorites, and traced in the spectra of young stars, include large crystalline grains that must have undergone annealing or condensation at temperatures in excess of ...

journal_title：Nature

authors： Vinković D

更新日期：2009-05-14 00:00:00

abstract：:The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding of the aetiologies of complex diseases and may also facilitate the development of novel therapeutic interventions. We have generated iPSCs from patients with L...

journal_title：Nature

authors： Carvajal-Vergara X,Sevilla A,D'Souza SL,Ang YS,Schaniel C,Lee DF,Yang L,Kaplan AD,Adler ED,Rozov R,Ge Y,Cohen N,Edelmann LJ,Chang B,Waghray A,Su J,Pardo S,Lichtenbelt KD,Tartaglia M,Gelb BD,Lemischka IR

更新日期：2010-06-10 00:00:00

abstract：:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

journal_title：Nature

authors： Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

更新日期：1985-11-07 00:00:00

abstract：:Pathfinding by growing axons in the developing nervous system is guided by diffusible or bound factors that attract or repel the axonal growth cone. The cytoplasmic signalling mechanisms that trigger the responses of the growth cone to guidance factors are mostly unknown. Previous studies have shown that the level and...

journal_title：Nature

authors： Hong K,Nishiyama M,Henley J,Tessier-Lavigne M,Poo M

更新日期：2000-01-06 00:00:00

abstract：:Since the first aeroplane flight more than 100 years ago, aeroplanes have been propelled using moving surfaces such as propellers and turbines. Most have been powered by fossil-fuel combustion. Electroaerodynamics, in which electrical forces accelerate ions in a fluid1,2, has been proposed as an alternative method of ...

journal_title：Nature

authors： Xu H,He Y,Strobel KL,Gilmore CK,Kelley SP,Hennick CC,Sebastian T,Woolston MR,Perreault DJ,Barrett SRH

更新日期：2018-11-01 00:00:00

abstract：:Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membra...

journal_title：Nature

authors： Gundersen CB,Miledi R,Parker I

更新日期：1984-03-29 00:00:00

abstract：:Bioluminescent symbioses range from facultative associations to highly adapted, apparently obligate ones. The family Anomalopidae (flashlight fishes) encompasses five genera of tropical reef fishes that have large suborbital light organs. The suborder Ceratioidei (deep-sea anglerfishes) contains 11 families. In nine o...

journal_title：Nature

authors： Haygood MG,Distel DL

更新日期：1993-05-13 00:00:00

abstract：:The masses of the supermassive black holes found in galaxy bulges are correlated with a multitude of galaxy properties, leading to suggestions that galaxies and black holes may evolve together. The number of reliably measured black-hole masses is small, and the number of methods for measuring them is limited, holding ...

journal_title：Nature

authors： Davis TA,Bureau M,Cappellari M,Sarzi M,Blitz L

更新日期：2013-02-21 00:00:00

abstract：:For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...

journal_title：Nature

authors： Okuda S,Tsutsui H,Shiina K,Sprunck S,Takeuchi H,Yui R,Kasahara RD,Hamamura Y,Mizukami A,Susaki D,Kawano N,Sakakibara T,Namiki S,Itoh K,Otsuka K,Matsuzaki M,Nozaki H,Kuroiwa T,Nakano A,Kanaoka MM,Dresselhaus T,Sa

更新日期：2009-03-19 00:00:00

abstract：:Crustal faults have long been identified as sites where localized sliding motion occurs during earthquakes, which allows for the relative motion between adjacent crustal blocks. Although there is a growing awareness that we must understand the evolution of fault systems on many timescales to relate present-day crustal...

journal_title：Nature

authors： Vidale JE,Li YG

更新日期：2003-01-30 00:00:00

abstract：:Inclusive fitness theory predicts that organisms can often increase their fitness by helping relatives. Indeed, many animals modify their behaviour towards kin in a fashion consistent with theory. Morphogenesis may also be sensitive to kinship environment, especially in species that facultatively produce distinct morp...

journal_title：Nature

authors： Pfennig DW,Collins JP

更新日期：1993-04-29 00:00:00

abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...

journal_title：Nature

authors： Foote M,Sepkoski JJ Jr

更新日期：1999-04-01 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：:This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...

journal_title：Nature

authors： Silberberg D,Anand NP,Michels K,Kalaria RN

更新日期：2015-11-19 00:00:00

abstract：:The growth of plants depends on continuous function of the meristems. Shoot meristems are responsible for all the post-embryonic aerial organs, such as leaves, stems and flowers. It has been assumed that the phytohormone cytokinin has a positive role in shoot meristem function. A severe reduction in the size of merist...

journal_title：Nature

authors： Kurakawa T,Ueda N,Maekawa M,Kobayashi K,Kojima M,Nagato Y,Sakakibara H,Kyozuka J

更新日期：2007-02-08 00:00:00

abstract：:Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances i...

journal_title：Nature

authors： Rioux JD,Abbas AK

更新日期：2005-06-02 00:00:00

abstract：:Cocaine is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulati...

journal_title：Nature

authors： Carrera MR,Ashley JA,Parsons LH,Wirsching P,Koob GF,Janda KD

更新日期：1995-12-14 00:00:00

abstract：:HIV-1 protease processes the Gag and Gag-Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation. The mature protease is active only as a dimer with each subunit contributing catalytic residues. The full-length transframe region protease pr...

journal_title：Nature

authors： Tang C,Louis JM,Aniana A,Suh JY,Clore GM

更新日期：2008-10-02 00:00:00

abstract：:Since Bridgman's discovery of five solid water (H2O) ice phases1 in 1912, studies on the extraordinary polymorphism of H2O have documented more than seventeen crystalline and several amorphous ice structures2,3, as well as rich metastability and kinetic effects4,5. This unique behaviour is due in part to the geometric...

journal_title：Nature

authors： Millot M,Coppari F,Rygg JR,Correa Barrios A,Hamel S,Swift DC,Eggert JH

更新日期：2019-05-01 00:00:00

abstract：:Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory pathways. However, how ATP is released to fulfil this function is not fully understood. Here we show that calcium homeostasis modulator 1 ...

journal_title：Nature

authors： Taruno A,Vingtdeux V,Ohmoto M,Ma Z,Dvoryanchikov G,Li A,Adrien L,Zhao H,Leung S,Abernethy M,Koppel J,Davies P,Civan MM,Chaudhari N,Matsumoto I,Hellekant G,Tordoff MG,Marambaud P,Foskett JK

更新日期：2013-03-14 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00