Abstract：
:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a large extracellular domain and a mandatory dimeric structure. Recent studies have revealed how these receptors are activated through multiple allosteric interactions between subunit domains. It emerges that the molecular complexity of these receptors is further increased through association with trafficking, effector and regulatory proteins. The structure and composition of these receptors present opportunities for therapeutic intervention in mental health and neurological disorders.
journal_name
Naturejournal_title
Natureauthors
Pin JP,Bettler Bdoi
10.1038/nature20566subject
Has Abstractpub_date
2016-12-01 00:00:00pages
60-68issue
7631eissn
0028-0836issn
1476-4687pii
nature20566journal_volume
540pub_type
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