Abstract:
:In contrast to double-stranded DNA, there has so far been little evidence that double-stranded RNA can undergo major conformational transitions. We have investigated the conformation in different conditions of the double-stranded RNA molecule poly(G-C).poly(G-C), by NMR, circular dichroism and absorbance spectroscopy. We report here evidence obtained by these different spectroscopic techniques that poly(G-C).poly(G-C) undergoes a transition from the A-form to a left-handed Z-form in conditions of high ionic strength and at temperatures above 35 degrees C. This conformational transition may be of relevance to the biological situations in which double-stranded RNA occurs, such as in ribosomes and in some viruses.
journal_name
Naturejournal_title
Natureauthors
Hall K,Cruz P,Tinoco I Jr,Jovin TM,van de Sande JHdoi
10.1038/311584a0subject
Has Abstractpub_date
1984-10-11 00:00:00pages
584-6issue
5986eissn
0028-0836issn
1476-4687journal_volume
311pub_type
杂志文章相关文献
NATURE文献大全abstract::DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0546-8
更新日期:2018-10-01 00:00:00
abstract::A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08822
更新日期:2010-02-18 00:00:00
abstract::Water-driven fracture propagation beneath supraglacial lakes rapidly transports large volumes of surface meltwater to the base of the Greenland Ice Sheet. These drainage events drive transient ice-sheet acceleration and establish conduits for additional surface-to-bed meltwater transport for the remainder of the melt ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14480
更新日期:2015-06-04 00:00:00
abstract::The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells. Here we explore the contribution of the mechanical pressure exerted by tumour growth onto non-tumorous adjacent epithelium. In t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14329
更新日期:2015-07-02 00:00:00
abstract::A large number of high-accuracy vector measurements of the Earth's magnetic field have recently become available from the satellite Oersted, complementing previous vector data from the satellite Magsat, which operated in 1979/80. These data can be used to infer the morphology of the magnetic field at the surface of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01879
更新日期:2003-08-14 00:00:00
abstract::Understanding brain circuits begins with an appreciation of their component parts - the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature12983
更新日期:2014-01-16 00:00:00
abstract::Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02191
更新日期:2003-12-11 00:00:00
abstract::The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25931
更新日期:1998-09-10 00:00:00
abstract::The chemical evolution of the Earth and the terrestrial planets is largely controlled by the density of silicate melts. If melt density is higher than that of the surrounding solid, incompatible elements dissolved in the melt will be sequestered in the deep mantle. Previous studies on dry (water-free) melts showed tha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04241
更新日期:2005-11-24 00:00:00
abstract::Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35010000
更新日期:2000-04-27 00:00:00
abstract::Infants acquire whatever language is spoken in the environment into which they are born. The mental capability of the newborn child is not biased in any way towards the acquisition of one human language rather than another. Because psychologists who attempt to model the process of language comprehension are interested...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304159a0
更新日期:1983-07-14 00:00:00
abstract::Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. Here we resolve these inconsistencies and show th...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature14565
更新日期:2015-07-30 00:00:00
abstract::The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05932
更新日期:2007-07-12 00:00:00
abstract::Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is ver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330132a0
更新日期:1987-11-12 00:00:00
abstract::The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0593-1
更新日期:2018-10-01 00:00:00
abstract::Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2929-x
更新日期:2020-11-01 00:00:00
abstract::Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is present in the nucleus o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08448
更新日期:2009-10-08 00:00:00
abstract::Although it has been proposed that the activation of T lymphocytes is mediated by an early rise in cytosolic calcium concentration, it has not been possible to mimic antigen- or mitogen-induced mouse lymphocyte activation by calcium ionophores that bypass receptor-mediated processes. There is now evidence from other s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313318a0
更新日期:1985-01-24 00:00:00
abstract::Microbialites, including biogenic stromatolites, thrombolites and dendrolites, were formed by various microbial mats that trapped and bound sediments or formed the locus of mineral precipitation. Microbialites were common and diverse during the Proterozoic, but declined in abundance and morphological diversity when mu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02654
更新日期:2004-07-01 00:00:00
abstract::Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326662a0
更新日期:1987-04-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2544-x
更新日期:2020-08-01 00:00:00
abstract::Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13729
更新日期:2014-10-02 00:00:00
abstract::Data from a rocket experiment show details which were not known from ground-based observations. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/226526a0
更新日期:1970-05-09 00:00:00
abstract::Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance for improved fracture healing or pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13146
更新日期:2014-03-20 00:00:00
abstract::Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules, a family of non-polymorphic, beta ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372691a0
更新日期:1994-12-15 00:00:00
abstract::Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35048617
更新日期:2000-12-14 00:00:00
abstract::Lignin is a complex polymer of phenylpropanoid subunits. It is an essential component of woody tissue, to which it imparts structural rigidity. Lignin is remarkably resistant to degradation by most microbes; nevertheless, a few species of white-rot fungi are able to catalyse its oxidation to CO2. Its biodegradation is...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326520a0
更新日期:1987-04-02 00:00:00
abstract::Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03890
更新日期:2005-08-04 00:00:00
abstract::A decision is a commitment to a proposition or plan of action based on evidence and the expected costs and benefits associated with the outcome. Progress in a variety of fields has led to a quantitative understanding of the mechanisms that evaluate evidence and reach a decision. Several formalisms propose that a repre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08275
更新日期:2009-09-10 00:00:00
abstract::The subsidence history of the Bahamian Platform points to a non-uniform rate of sea-floor spreading since the beginning of the Cretaceous. Lower Cretaceous rates of perhaps 5 cm/yr led to an active trench system at the boundary between the American and Caribbean lithosphere plates, and the rapid subsidence of the cont...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/2251226a0
更新日期:1970-03-28 00:00:00