Abstract:
:Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.
journal_name
Naturejournal_title
Natureauthors
McLean JW,Tomlinson JE,Kuang WJ,Eaton DL,Chen EY,Fless GM,Scanu AM,Lawn RMdoi
10.1038/330132a0subject
Has Abstractpub_date
1987-11-12 00:00:00pages
132-7issue
6144eissn
0028-0836issn
1476-4687journal_volume
330pub_type
杂志文章相关文献
NATURE文献大全abstract::The upright posture and obligatory bipedalism of modern humans are unique among living primates. The evolutionary history of this behaviour has traditionally been pursued by functional analysis of the postcranial skeleton and the preserved footprint trails of fossil hominids. Here we report a systematic attempt to rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369645a0
更新日期:1994-06-23 00:00:00
abstract::T-cell clones that grow continuously in tissue culture have become a major tool for studying the properties of T lymphocytes. It is therefore important to know to what extent such clones resemble their normal counterparts. Several reports have appeared recently which demonstrate that long-term T-cell lines may lose th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308367a0
更新日期:1984-03-22 00:00:00
abstract::The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279492a0
更新日期:1979-06-07 00:00:00
abstract::The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286822a0
更新日期:1980-08-21 00:00:00
abstract::The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358584a0
更新日期:1992-08-13 00:00:00
abstract::Quantum mechanical experiments in ring geometries have long fascinated physicists. Open rings connected to leads, for example, allow the observation of the Aharonov-Bohm effect, one of the best examples of quantum mechanical phase coherence. The phase coherence of electrons travelling through a quantum dot embedded in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35101552
更新日期:2001-10-25 00:00:00
abstract::Topological physics relies on the structure of the eigenstates of the Hamiltonians. The geometry of the eigenstates is encoded in the quantum geometric tensor1-comprising the Berry curvature2 (crucial for topological matter)3 and the quantum metric4, which defines the distance between the eigenstates. Knowledge of the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1989-2
更新日期:2020-02-01 00:00:00
abstract::Evolution of the earliest mammals shows successive episodes of diversification. Lineage-splitting in Mesozoic mammals is coupled with many independent evolutionary experiments and ecological specializations. Classic scenarios of mammalian morphological evolution tend to posit an orderly acquisition of key evolutionary...
journal_title:Nature
pub_type: 历史文章,杂志文章,评审
doi:10.1038/nature06277
更新日期:2007-12-13 00:00:00
abstract::Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2632-y
更新日期:2020-08-01 00:00:00
abstract::We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytog...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/377335a0
更新日期:1995-09-28 00:00:00
abstract::Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23674
更新日期:2017-10-05 00:00:00
abstract::Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35050141
更新日期:2000-12-21 00:00:00
abstract::Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04672
更新日期:2006-04-27 00:00:00
abstract::Wolbachia is a common maternally inherited bacterial symbiont able to induce crossing sterilities known as cytoplasmic incompatibility (CI) in insects. Wolbachia-modified sperm are unable to complete fertilization of uninfected ova, but a rescue function allows infected eggs to develop normally. By providing a reprodu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03629
更新日期:2005-07-14 00:00:00
abstract::Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. At...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12663
更新日期:2013-10-17 00:00:00
abstract::Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363715a0
更新日期:1993-06-24 00:00:00
abstract::Arachidonic acid is released by phospholipase A2 when activation of N-methyl-D-aspartate (NMDA) receptors by neurotransmitter glutamate raises the calcium concentration in neurons, for example during the initiation of long-term potentiation and during brain anoxia. Here we investigate the effect of arachidonic acid on...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355722a0
更新日期:1992-02-20 00:00:00
abstract::It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escheric...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07282
更新日期:2008-10-30 00:00:00
abstract::The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347406a0
更新日期:1990-09-27 00:00:00
abstract::The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35030177
更新日期:2000-09-21 00:00:00
abstract::An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/427802a
更新日期:2004-02-26 00:00:00
abstract::Since the origins of agriculture, the scale of human cooperation and societal complexity has dramatically expanded. This fact challenges standard evolutionary explanations of prosociality because well-studied mechanisms of cooperation based on genetic relatedness, reciprocity and partner choice falter as people increa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16980
更新日期:2016-02-18 00:00:00
abstract::Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15722
更新日期:2015-10-29 00:00:00
abstract::It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341154a0
更新日期:1989-09-14 00:00:00
abstract::Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17160
更新日期:2016-03-24 00:00:00
abstract::Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature02852
更新日期:2004-09-16 00:00:00
abstract::In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1609-1
更新日期:2019-10-01 00:00:00
abstract::A review of fossil mammalian faunas from the Middle Awash indicates they span most of the later Neogene and document evolutionary change in several mammalian groups, especially Primates, Proboscidea and Artiodactyla. Oldowan artefacts first appear in the late Pliocene, while Acheulian and later industries and apparent...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298025a0
更新日期:1982-07-01 00:00:00
abstract::Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus restored grasping abilities after hand paralysis. Theoretically, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20118
更新日期:2016-11-10 00:00:00
abstract::Modern agriculture has accelerated biological methane and nitrogen cycling on a global scale. Freshwater sediments often receive increased downward fluxes of nitrate from agricultural runoff and upward fluxes of methane generated by anaerobic decomposition. In theory, prokaryotes should be capable of using nitrate to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04617
更新日期:2006-04-13 00:00:00