Abstract:
:Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well preserved skull of a Homo erectus infant, by computed tomography. Comparison with a large series of extant humans and chimpanzees indicates that this individual was about 1 yr (0-1.5 yr) old at death and had an endocranial capacity at 72-84% of an average adult H. erectus. This pattern of relative brain growth resembles that of living apes, but differs from that seen in extant humans. It implies that major differences in the development of cognitive capabilities existed between H. erectus and anatomically modern humans.
journal_name
Naturejournal_title
Natureauthors
Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob Tdoi
10.1038/nature02852keywords:
subject
Has Abstractpub_date
2004-09-16 00:00:00pages
299-302issue
7006eissn
0028-0836issn
1476-4687pii
nature02852journal_volume
431pub_type
历史文章,杂志文章相关文献
NATURE文献大全abstract::The sequence-specific DNA-binding protein, MyoD, can activate muscle-specific gene expression in some cells in culture. Xenopus MyoD (XMyoD) transcription is activated as a consequence of mesoderm induction in the early myotomes, from which the axial musculature develops. XMyoD RNA accumulates about two hours before m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347197a0
更新日期:1990-09-13 00:00:00
abstract::The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact h...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/367425a0
更新日期:1994-02-03 00:00:00
abstract::Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35101621
更新日期:2001-10-25 00:00:00
abstract::Whether or not the Large Hadron Collider reveals the long-awaited Higgs particle, it is likely to lead to discoveries that add to, or challenge, the standard model of particle physics. Data produced will be pored over for any evidence of supersymmetric partners for the existing denizens of the particle 'zoo' and for t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06079
更新日期:2007-07-19 00:00:00
abstract::The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfill promises made two years ago. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415457a
更新日期:2002-01-31 00:00:00
abstract::Endothelial cells line the inner surface of blood vessels and act as the main barrier to the passage of cells and large molecules from the blood stream to the tissues. Recent interest in the part played by the endothelium in regulating vascular tone has focused on the synthesis and secretion of prostacyclin and an end...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325811a0
更新日期:1987-02-26 00:00:00
abstract::Japan's Ministry of Health will fund a major new heart transplantation project in an effort to resume heart transplants halted by a public outcry against the first such transplant 17 years ago. Opposition to organ donation, which has been attributed variously to Buddhist and Confucian views of the body and to Japanes...
journal_title:Nature
pub_type: 新闻
doi:10.1038/313338a0
更新日期:1985-01-31 00:00:00
abstract::Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/433476a
更新日期:2005-02-03 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07033-5
更新日期:2018-10-01 00:00:00
abstract::Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/272028a0
更新日期:1978-03-02 00:00:00
abstract::Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11783
更新日期:2013-02-07 00:00:00
abstract::Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20598
更新日期:2016-12-15 00:00:00
abstract::A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/264715a0
更新日期:1976-12-23 00:00:00
abstract::Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The 'Phillips' mechanism is widely held as the paradig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35090602
更新日期:2001-08-23 00:00:00
abstract::Pinocytosis and membrane ruffling are among the earliest and most dramatic cellular responses to stimulation by growth factors or other mitogens. The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382177a0
更新日期:1996-07-11 00:00:00
abstract::Since the discovery of plate tectonics, the relative importance of driving forces of plate motion has been debated. Resolution of this issue has been hindered by uncertainties in estimates of basal traction, which controls the coupling between lithospheric plates and underlying mantle convection. Hotspot tracks preser...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05675
更新日期:2007-03-22 00:00:00
abstract::Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23674
更新日期:2017-10-05 00:00:00
abstract::The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07024
更新日期:2008-07-03 00:00:00
abstract::Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07776
更新日期:2009-03-19 00:00:00
abstract::The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/414638a
更新日期:2001-12-06 00:00:00
abstract::Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10821
更新日期:2012-01-25 00:00:00
abstract::The Pax-6 transcription-factor gene, containing a paired domain and a paired-type homeodomain, is conserved in structure and ubiquitously present among Metazoa. It is required for development of the central nervous system, and is mutated in human aniridia, mouse and rat small eye and Drosophila eyeless. We identified ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/377055a0
更新日期:1995-09-07 00:00:00
abstract::Asexual reproduction by free-living invertebrate larvae is a rare and enigmatic phenomenon and, although it is known to occur in sea stars and brittle stars, it has not been detected in other echinoderms despite more than a century of intensive study. Here we describe spontaneous larval cloning in three species from t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/425146a
更新日期:2003-09-11 00:00:00
abstract::The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353353a0
更新日期:1991-09-26 00:00:00
abstract::The AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun and c-Fos, controls the stimulation of cellular genes by growth factors and the expression of oncogenes, including src and ras. Transcriptional activation by c-Jun is regulated by a cell-type-specific inhibitor that represses th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352165a0
更新日期:1991-07-11 00:00:00
abstract::Immune-challenged vertebrate females transfer specific antibodies to their offspring, but this gratuitous immunity cannot operate in invertebrates. Here we show that constitutive immune defence is enhanced in sexual offspring of the bumble-bee Bombus terrestris L. when the parental colony is immune-challenged. Our fin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35107138
更新日期:2001-11-29 00:00:00
abstract::Several distinct cell lineages are established during mouse embryogenesis. The trophectoderm and primitive endoderm give rise to extraembryonic structures alone, while the primitive ectoderm becomes the fetus proper. Recent studies suggest that the levels of DNA modification are lower in inactive X chromosomes from ex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307284a0
更新日期:1984-01-19 00:00:00
abstract::Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065689
更新日期:2001-03-08 00:00:00
abstract::A long-standing hypothesis on tumorigenesis is that cell division failure, generating genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies. Here we test this idea by transiently blocking cytokinesis in p53-null (p53-/-) mouse mammary epithelial cells (MMECs), enabling the isolat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04217
更新日期:2005-10-13 00:00:00
abstract::In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07580
更新日期:2009-01-29 00:00:00