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High brain densities of the immunophilin FKBP colocalized with calcineurin.

Abstract：

:The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds the cyclophilin-cyclosporin A and FKBP-FK506 complexes, indicating that calcineurin might mediate the actions of these drugs. A physiological role for the immunophilins in the nervous system is implied by a close homology between the structure of NINA A, a protein in the neural retina of Drosophila, and cyclophilin, as well as by the high density of FKBP messenger RNA in brain tissue. Here we report that the levels of FKBP and mRNA in rat brain are extraordinarily high and that their regional localization is virtually identical to that of calcineurin, indicating that there may be a physiological link between calcineurin and the immunophilins. We also show that at low concentrations FK506 and cyclosporin A enhance the phosphorylation of endogenous protein substrates in brain tissue and in intact PC12 cells, indicating that these drugs may inhibit phosphatase activity by interacting with the immunophilin-calcineurin complexes.

journal_name

Nature

journal_title

Nature

authors

Steiner JP,Dawson TM,Fotuhi M,Glatt CE,Snowman AM,Cohen N,Snyder SH

doi

10.1038/358584a0

keywords:

subject

Has Abstract

pub_date

1992-08-13 00:00:00

pages

584-7

issue

6387

eissn

0028-0836

issn

1476-4687

journal_volume

358

pub_type

杂志文章

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