Abstract：
:In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) has a double-stranded DNA genome, and it has recently been shown that the minus DNA strand of the HBV genome is copied from a plus-strand RNA template, leading to the suggestion that reverse transcription is central to the life cycle of HBV. More recently it has been suggested that the replication cycle of a plant virus, cauliflower mosaic virus (CaMV), includes a reverse transcription step. We report here the existence of amino acid sequence homology between retroviral reverse transcriptase and the putative polymerases of HBV and CaMV.
journal_name
Naturejournal_title
Natureauthors
Toh H,Hayashida H,Miyata Tdoi
10.1038/305827a0subject
Has Abstractpub_date
1983-10-27 00:00:00pages
827-9issue
5937eissn
0028-0836issn
1476-4687journal_volume
305pub_type
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